Metastatic Neuroblastoma Presenting as a Submandibular Mass with Mandibular Bone Involvement in a Three-Year-Old Child

Abstract

Although neuroblastoma is one of the most common extra-cranial tumors in the pediatric population, it is rarely seen as a metastasis to the mandibular bone. The following is a case report of a 3-year-old male who initially presented with a submandibular mass that was proven to be a poorly differentiated metastatic neuroblastoma through excisional biopsy. This report is one of the few case reports that demonstrates metastatic submandibular neuroblastoma with mandibular bone involvement in the pediatric population.

Unusual tumor metastasis from neuroblastoma in a pediatric patient. Case report

“…Finally, to eradicate minimal residual disease, surgical procedures are performed depending on the location of the tumor site. Targeted immunotherapy with anti-ganglioside antibodies directed at G D2, the predominant antigen on neuroblastoma cells, also seems to be a promising approach for the intervention of neuroblastomas 15 .…”

Anaplastic Lymphoma Kinase (ALK)-Negative Inflammatory Myofibroblastic Tumor of the Kidney in a Nine-Month-Old Girl

“…However, preliminary research suggests that an inflammatory response following surgery, trauma, or infection may contribute to the pathogenesis of IMT [ 4 , 5 ]. Recent data emphasize the neoplastic component of the disease and suggest it as a possible cause due to its local aggressive behavior and evidence of cytogenetic clonality with overexpression of the anaplastic lymphoma kinase (ALK) gene [ 5 , 6 ]. Also, the clinical manifestations of the IMT are mainly site specific, and, in the case of renal IMT, the patient usually presents with hematuria lumbar pain [ 7 ].…”