Metastatic neuroendocrine carcinoma in the skin

Garcia, Andres; Mays, Steven R.; Silapunt, Sirunya

doi:10.5070/d3231033676

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…A PubMed search of articles indexed for MEDLINE using the terms metastatic AND [carcinoid OR neuroendocrine] tumors AND [skin OR cutaneous] revealed 47 cases. [7][8][9][10][11] Similar to other skin metastases, cutaneous metastases of carcinoid tumors commonly present as firm erythematous nodules of varying sizes that may be asymptomatic, tender, or pruritic (Figure 1). Cases of carcinoid tumors with cutaneous metastasis as the initial and only presenting sign are exceedingly rare.…”

Section: The Diagnosismentioning

confidence: 99%

Firm Mobile Nodule on the Scalp

Hwang¹

2022

Cutis

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A 47-year-old woman was admitted to the hospital with abdominal pain and flushing. She had a history of a midgut carcinoid that originated in the ileum with metastasis to the colon, liver, and pancreas. Dermatologic examination revealed a firm, nontender, mobile, 7-mm scalp nodule with a pink-purple overlying epidermis. The lesion was associated with a slight decrease in hair density. A 4-mm punch biopsy was performed. THE BEST DIAGNOSIS IS:a. basal cell carcinoma b. Merkel cell carcinoma c. metastatic carcinoid tumor d. metastatic small cell lung carcinoma e. superficial Ewing sarcoma family of tumors

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Section: The Diagnosismentioning

confidence: 99%

Firm Mobile Nodule on the Scalp

Hwang¹

2022

Cutis

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Unexpected response to palliative radiotherapy for subcutaneous metastases of an advanced small cell pancreatic neuroendocrine carcinoma: a case report of two different radiation schedules

Ciliberti¹,

Carbonara

Grillo³

et al. 2020

BMC Cancer

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Background: Skin metastases from pancreatic neuroendocrine carcinoma (PNEC) are rare and their palliative treatment is challenging. We report our experience in the multimodal management of one of the few reported cases of metastatic PNEC with multiple visceral and subcutaneous secondary lesions, focusing on the effectiveness of palliative radiotherapy for skin metastases. Case presentation: A 61-years old woman affected by a metastatic PNECwith subcutaneous growing and bleeding secondary lesions (at the scalp, right scapular region and at the back of the left thoracic wall, respectively) obtained a successful control of visceral metastases with the use of chemotherapy and an unexpected local response of her skin metastases with palliative radiotherapy. In particular, two subsequent radiation treatments were performed using different fractionation schedules (30 Gy in 10 fractions and 20 Gy in 5 fractions, respectively). Both radiation treatments were well-tolerated and patient's quality of life was improved. Local response was maintained until patient's deaththat occurred due to cachexia. Conclusions: The presented case highlights the effectiveness and the good tolerance of radiotherapy in the treatment of subcutaneous metastases; nevertheless, further knowledge of the optimal local palliative approach for PNEC metastatic sites is necessary. The experience gained in this work is the occasion to encourage a routine integrated multidisciplinary team management of metastatic PNECs because of their clinical complexity. The aim is to guarantee the optimization of the care with personalized and more effective systemic and local treatmentsalso including supportive cares and treatment-related side effects management.

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Skin Metastases of Gastrointestinal Neuroendocrine Tumors – Literature Review

2022

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Introduction: Gastrointestinal neuroendocrine neoplasms arise from cells of a diffuse endocrine system (DES) located in the digestive tract. They are often diagnosed in an advanced stage, when distant metastases appear. Skin metastases of the neuroendocrine tumors are extremely rare. Material and methods: Literature search across PubMed and Medline databases from 1969 up to 2021 was performed. We reviewed English literature according to Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. The following keywords were used: neuroendocrine tumor, neuroendocrine neoplasm, neuroendocrine carcinoma, NET, NEN, skin and cutaneous metastases, lymph nodes. Characteristics of patients, grading, tumor localization and other data that was found in publications were assessed. Case reports and case series were included. Results: The initial search strategy yielded 14 results in PubMed and 3 in Medline database. We removed the duplicates after we have imported the citations with a citation manager. We found 17 publications of the skin metastases of neuroendocrine neoplasms. The analysis of 18 cases concerned 13 NECs and 5 NETs. Conclusion: In most cases, the metastases are small, painless and located on the scalp or lower limbs. Skin metastases may be the first symptom of the disease. The pancreas is the most common primary tumor site. Discussion: NEN metastases to the skin are often diagnosed with disseminated neoplastic process, which is associated with poor prognosis and high mortality. NET metastases to the skin may occur with an unknown primary site. Skin metastases of neuroendocrine tumors should be considered during the diagnosis process of skin tumors. Key words: neuroendocrine tumor, digestive tract, metastases, skin

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Metastatic neuroendocrine carcinoma in the skin

Cited by 3 publications

References 8 publications

Firm Mobile Nodule on the Scalp

Firm Mobile Nodule on the Scalp

Unexpected response to palliative radiotherapy for subcutaneous metastases of an advanced small cell pancreatic neuroendocrine carcinoma: a case report of two different radiation schedules

Skin Metastases of Gastrointestinal Neuroendocrine Tumors – Literature Review

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