Metastatic nonhematopoietic neoplasms to the breast: a study of 238 cases

Zhou, Ping; Chang, Nina; Abraham, Susan C.; Albarracin, Constance T.; Huo, Lei; Chen, Hui; Ding, Qingqing; Resetkova, Erika; Middleton, Lavinia P.; Şahin, Ayşegül; Bu, Hong; Wu, Yun

doi:10.1016/j.humpath.2022.04.009

Cited by 11 publications

(6 citation statements)

References 32 publications

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“…The most common metastatic tumors were as follows: malignant melanoma (42%), serous carcinoma (15%), neuroendocrine neoplasia (13%). 20 In our study, carcinoma was the most frequent and malignant melanoma was the second most common tumor group. The skin is the most common primary organ that metastasized.…”

Section: Discussionmentioning

confidence: 52%

“…21 Zhou et al mentioned that when the clinical history is available to the pathologist, the correct diagnosis rate is 100% and this rate drops to 58% in cases where the clinical history is not known. 20 Serous carcinoma is one of the tumors that commonly metastasize to the breast and is often misdiagnosed if the clinical history is unknown. Growth pattern similar to micropapillary breast carcinoma, mimic inflammatory breast carcinoma clinically, and showing hormone positivity are some of the reasons for misdiagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic Neoplasms to the Breast

Özşen,

Tolunay,

Polatkan

et al. 2023

Int J Surg Pathol

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Objective When the clinical presentation is related to the metastatic mass and a radiologically solitary tumor focus is detected, especially in cases where clinical information is not taken into account or is insufficient, if a possible metastatic neoplasia is not kept in mind then it is possible to evaluate the tumor as a primary breast neoplasm. In this study, it is aimed to present our cases of non-hematopoietic metastatic neoplasms and to evaluate the clinicopathological features that may aid in distinguishing metastatic from primary neoplasms. Material and Methods This study includes cases diagnosed with metastatic non-hematopoietic breast neoplasm in breast resection materials in our center, between the years 2010–2023. All cases were analyzed retrospectively by evaluating clinicopathological features. Results Of the 15 subjects included in the study, 11 (73%) were female and 4 (27%) were male. The mean age of the patients were 46.9 ranged from 22 to 63 years. The most frequent metastatic malignancy was carcinoma (60%), followed by melanoma (33%) and sarcoma (7%). Of the 9 patients with metastatic carcinoma, the primary tumor originated from the lungs in 4, from gastrointestinal system in 2, female genital tract in 2, and kidney in 1 patient. Sarcoma diagnosis was given in a single patient and the histology was a leiomyosarcoma originating from kidney. Conclusion A careful histomorphological and immunohistochemical evaluation and a detailed examination of the clinicoradiological data are critical to establish the right course in patient management, treatment plan and to correctly predict the prognosis.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Metastatic Neoplasms to the Breast

Özşen,

Tolunay,

Polatkan

et al. 2023

Int J Surg Pathol

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“…A study by Zhou et al [ 8 ] found that five out of nine cases of metastatic melanoma in the breast were misdiagnosed as primary poorly differentiated invasive breast carcinoma. Of these cases, four had a history of melanoma, one had none, and this history was not known to the reporting histopathologist in all five cases.…”

Section: Discussionmentioning

confidence: 99%

Metastatic choroidal melanoma in the breast: a case report and review of the literature

Abudalu¹,

Malhotra²,

Nasir

et al. 2023

J Pathol Transl Med

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The breast is an unusual site for metastases, accounting for less than 2% of malignant breast lesions but include those from malignant melanomas, carcinomas, sarcomas, and lymphomas from various organs. We diagnosed a very rare case of metastatic choroidal melanoma for a 67-year-old female who presented with a right breast lump and who had been previously diagnosed with choroidal melanoma-monosomy 3 in 2017. To the best of our knowledge, only five such cases have been published so far, with one in a male patient.

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“…Hematologic neoplasms represent 1% of all malignant breast tumors. Solid organ metastases account for less than 1% of all breast neoplasms, including melanoma, carcinoma (adenocarcinoma and squamous cell carcinoma of the lung and gastrointestinal tract, renal and prostate adenocarcinoma), carcinoid tumor, and sarcoma [1][2][3]. Metastasis presenting as a breast tumor has been reported to constitute 1.3-6.6% of all breast tumors.…”

Section: Introductionmentioning

confidence: 99%

Breast Metastasis From Cutaneous Melanoma: Beyond the Infiltrating Ductal Carcinoma

Ramos Portales,

Bermúdez Barrientos,

Rodríguez Valencia

et al. 2024

Cureus

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Breast metastases of extramammary origin are an extremely rare entity. Solid organ metastases to the breast include malignant melanoma, epithelial carcinoma (adenocarcinoma and squamous cell carcinoma of the lung and gastrointestinal tract), and sarcoma. A breast neoplasm can be caused by a primary tumor, intransit metastasis, breast metastasis, and skin metastasis. A 42-year-old female patient presented with a hyperpigmented lesion on the first finger of her left hand. An incisional biopsy was carried out, reporting pigmented epithelioid melanoma. Amputation of the finger was performed, as well as an axillary sentinel lymph node excision. Later during the treatment and follow-up by medical oncology, a breast tumor was located, followed by a protocol and the approach of possible differential diagnoses. Finally, it was characterized as metastatic cutaneous melanoma. The therapeutic approach regarding the possible origin of the metastatic neoplastic character of breast tumors culminated in this case in the palliative treatment with immunotherapy of cutaneous malignant melanoma. The diagnosis of breast metastases from cutaneous malignant melanoma is a real challenge, so an extensive history and high clinical suspicion are crucial in order to provide adequate treatment, despite the gloomy prognosis.

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Metastatic nonhematopoietic neoplasms to the breast: a study of 238 cases

Cited by 11 publications

References 32 publications

Metastatic Neoplasms to the Breast

Metastatic Neoplasms to the Breast

Metastatic choroidal melanoma in the breast: a case report and review of the literature

Breast Metastasis From Cutaneous Melanoma: Beyond the Infiltrating Ductal Carcinoma

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