METASTATIC OVARIAN NEUROBLASTOMA: A Case Report

Somjee, S; Pa, Kurkure; Chinoy, Roshan F.; Deshpande, Ramakant; Sh, Advani

doi:10.1080/088800199277029

Cited by 13 publications

(5 citation statements)

References 4 publications

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“…Data on histological analysis were available for patients who had ovarian tissue cryopreservation for medulloblastoma and neuroblastoma and suggested no ovarian involvement (Poirot et al, 2007;Azem et al, 2010). Nevertheless, case reports and autopsy data have indicated that ovarian involvement in neuroblastoma does occur (Himelstein-Braw et al, 1977;Meyer et al, 1979;Sty et al, 1980;Young et al, 1993;Somjee et al, 1999;McCarville et al, 2001;Miyauchi et al, 2004).…”

Section: Other Tumoursmentioning

confidence: 99%

Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review

Bastings

Beerendonk

Westphal

et al. 2013

Human Reproduction Update

195

105

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BACKGROUND The risk of recurrent oncological disease due to the reintroduction of cancer cells via autotransplantation of cryopreserved ovarian tissue is unknown. METHODS A systematic review of literature derived from MEDLINE, EMBASE and the Cochrane Library was conducted. Studies on follow-up after autotransplantation; detection of cancer cells in ovarian tissue from oncological patients by histology, polymerase chain reaction or xenotransplantation; and epidemiological data on ovarian metastases were included. RESULTS A total of 289 studies were included. Metastases were repeatedly detected in ovarian tissue obtained for cryopreservation purposes from patients with leukaemia, as well as in one patient with Ewing sarcoma. No metastases were detected in ovarian tissue from lymphoma and breast cancer patients who had their ovarian tissue cryopreserved. Clinical studies indicated that one should be concerned about autotransplantation safety in patients with colorectal, gastric and endometrial cancer. For patients with low-stage cervical carcinoma, clinical data were relatively reassuring, but studies focused on the detection of metastases were scarce. Oncological recurrence has been described in one survivor of cervical cancer and one survivor of breast cancer who had their ovarian tissue autotransplanted, although these recurrences may not be related to the transplantation. CONCLUSIONS It is advisable to refrain from ovarian tissue autotransplantation in survivors of leukaemia. With survivors of all other malignancies, current knowledge regarding the safety of autotransplantation should be discussed. The most reassuring data regarding autotransplantation safety were found for lymphoma patients.

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Section: Other Tumoursmentioning

confidence: 99%

Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review

Bastings

Beerendonk

Westphal

et al. 2013

Human Reproduction Update

195

105

View full text Add to dashboard Cite

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“…Ovarian involvement appeared to be an autopsy finding in the majority of cases, as roughly one-third of neuroblastoma cases were reported to have ovarian tumour deposits histologically 8. In 2001, McCarville et al described a neuroblastoma case in whom the ovarian metastasis were diagnosed concomitantly, and in 2009, Somjee et al reported a 15-year-old girl who also had metastatic ovarian involvement 9 10…”

Section: Discussionmentioning

confidence: 99%

Neuroblastoma with an unusual ovarian metastasis in a 5-year-old girl

et al. 2019

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Neuroblastoma metastasizing to the ovary is rare. We report the 10th case and review the scarce literature. A 5-year-old girl with stage M neuroblastoma presented with an upper abdominal and a pelvic mass. Evaluation after induction showed very good tumour response with three remaining localisations: two abdominal and one pelvic. At gross total resection, the pelvic mass appeared to be the enlarged and abnormal right ovary and was removed completely. Pathology showed an ovarian metastasis. On completion of her postoperative treatment, she achieved complete remission. Literature review showed that underdiagnosing of ovarian metastasis in neuroblastoma is very likely.

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“…Although several studies have described the presence of metastases in NB, none have systematically sought ovarian metastases or explored the involvement of the ovaries as the study aim. Very few case reports of metastatic ovarian involvement in patients with NB have been described in the literature, yet NB is the childhood tumor that most frequently metastases to the ovary . Moreover, more than 60% of childhood metastatic NBs have circulating tumor cells at the time of diagnosis …”

Section: Discussionmentioning

confidence: 99%

“…The possible presence of tumor cells in the ovarian tissue collected from females with NB should be borne in mind for several reasons. In all the previously published studies, only histological analyses were performed, on only one to three randomly selected ovarian fragment sections, and this is not a highly sensitive technique for MRD detection …”

Section: Discussionmentioning

confidence: 99%

“…Neuroblastoma (NB) is the most common extracranial solid tumor in children, with a high metastatic potential. It is also the childhood solid tumor that spreads to the ovaries most frequently . In Europe, every year about 250 females with NB are given high‐dose chemotherapy followed by hematopoietic stem cell transplantation (sterilizing treatment), while others are exposed to intensive potentially gonadotoxic treatment.…”

Section: Introductionmentioning

confidence: 99%

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