Metastatic ovarian tumors: a review of 64 cases

Yada-Hashimoto, Namiko; Yamamoto, Takatsugu; Kamiura, Shoji; Seino, Hozumi; Ohira, Hiroto; Sawai, Keisuke; Kimura, Tadashi; Saji, Fumitaka

doi:10.1016/s0090-8258(03)00075-1

Cited by 189 publications

(146 citation statements)

References 9 publications

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“…The 5-year survival has been reported to be from 10% to 36%; worse than the 40% generally reported for primary ovarian cancer [4,7,8]. Survival is better for patients with metastatic tumors to the ovary from genital rather than non-genital origin [1,3]. Among the metastatic tumors to the ovaries, the Krukenberg tumor, which can account for 30% to 40% of metastatic cancers to the ovaries [9,10], is generally defined as an ovarian carcinoma that contains a significant component of mucin-filled signet ring cells typically lying within a cellular stroma derived from the ovarian stroma [11,12].…”

Section: Introductionmentioning

confidence: 91%

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The role of cytoreductive surgery for non-genital tract metastatic tumors to the ovaries

Kim

et al. 2010

European Journal of Obstetrics & Gynecology and Reproductiv

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Section: Introductionmentioning

confidence: 91%

“…The ovaries are frequent targets of metastasis for malignant tumors [1]. Distinction between primary and metastatic ovarian tumors is important because misinterpretation of a metastatic tumor as primary tumor may lead to inappropriate management and suboptimal treatment outcome [2].…”

Section: Introductionmentioning

confidence: 99%

The role of cytoreductive surgery for non-genital tract metastatic tumors to the ovaries

Kim

et al. 2010

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Though the primary site for metastatic ovarian cancer are various including breast, appendix, gall bladder, pancreas, uterine cervix, urinary bladder, renal pelvis etc. but the majority, more than 90% of the of the metastasis is from either stomach or colorectum [16]- [18]. Many study showed stomach to be the main primary site, some showed it being as high as 76% [16] [17] [19].…”

Section: Discussionmentioning

confidence: 99%

“…but the majority, more than 90% of the of the metastasis is from either stomach or colorectum [16]- [18]. Many study showed stomach to be the main primary site, some showed it being as high as 76% [16] [17] [19]. But some recent article also showed a higher incidence of KT of colorectal origin compared with those of gastric origin [17] [18].…”

Section: Discussionmentioning

confidence: 99%

An Up-to-Date Understanding of the “Krukenberg Tumor” Mechanism

Shah¹,

Tang²,

Karn³

2016

ARSci

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Krukenbergtumor is a metastatic ovarian tumor with its primary site being the gastrointestinal tract. The pathogenesis of Krukenberg tumor formation is still in its hypothetical stage though the current understanding suggests lymphatic, hematogenous and transcoelomic route as the 3 major route of metastasis. There is a lack of description in the literature related to the pathway of metastasis. Here, we intend to search the available literature and provide a thorough review, which may be helpful to the readers to understand the issue of mechanism of Krukenberg tumor metastasis more clearly.

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“…Colorectal cancer accounts one third of nongenital tumors metastatic to ovaries. [1][2][3][4] Among the patients with peritoneal carcinomatosis (PC) of epithelial ovarian cancer origin, cytoreductive surgery is the standard of care. An attempt at maximal removal of tumor burden yields better survival rates in ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Cytoreductive Surgery for Intestinal Cancer Patients Metastatic to Ovaries Presenting as Primary Ovarian Cancer

Arık¹

2016

UHOD

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Colorectal cancer accounts for one third of non-genital tumors metastasize to the ovaries. We aimed to investigate the role of cytoreductive surgery in colon and small intestinal cancer patients with adnexal metastases, which were operated as primary epithelial ovarian cancer. This analysis included 26 patients with adnexal metastasis from colon and distal ileum, patients presented as primary ovarian cancer cases and were operated upon in Zekai Tahir Burak Women's Health Hospital, Gynecologic Oncology Unit between 2008 and 2014. Patients with history of intestinal cancers were not included in the study. The median age of patients was 54 (range= 26-77). Among all patients, 63% were premenopausal and 37% were postmenopausal. Most common presenting symptom was abdominal distention (80%). Optimal cytoreduction was performed in 21 patients. Right hemicolon was the primary site of tumor in 8 patients, while recto-sigmoid and appendiceal tumors were present in 7 and 7 patients, respectively. Isolated ovarian metastases were found in 6 patients, the remaining 20 patients had peritoneal carcinomatosis. Median follow-up was 25 months (ranging 3-59). In total, 11 patients died, of them, two patients had isolated ovarian metastasis, while the remaining nine patients had peritoneal carcinomatosis. Estimated median overall survival was 36.8 months (95% CI= 28.6-45.1 months). Median overall survival of patients who underwent cytoreductive surgery was not reached (36.8+ months), compared with 18.3 (95% CI= 0.0-46.4) months for patients with suboptimal cytoreductive surgery (p= 0.008). This retrospective study showed that cytoreductive surgery might have beneficial effect in selected patients with intestinal cancer metastatic to the adnexal.

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Metastatic ovarian tumors: a review of 64 cases

Cited by 189 publications

References 9 publications

The role of cytoreductive surgery for non-genital tract metastatic tumors to the ovaries

The role of cytoreductive surgery for non-genital tract metastatic tumors to the ovaries

An Up-to-Date Understanding of the “Krukenberg Tumor” Mechanism

Cytoreductive Surgery for Intestinal Cancer Patients Metastatic to Ovaries Presenting as Primary Ovarian Cancer

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