Metastatic Patterns of Mediastinal Lymph Nodes in Small-Size Non-small Cell Lung Cancer (T1b)

Wu, Yijun; Han, Chang; Gong, Liang; Wang, Zhile; Liu, Jianghao; Liu, Xinyu; Chen, Xinyi; Chong, Yuming; Liang, Ning; Li, Shanqing

doi:10.3389/fsurg.2020.580203

Cited by 7 publications

(4 citation statements)

References 32 publications

(61 reference statements)

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“…However, the left lower lobe is more likely to have station 7 (78.6%). [ 77 ] Additionally, Wu et al [ 78 ] explore the association between lobe location and mediastinal stations, including skip N2 and non-skip N2 (NSN2). They demonstrate that the right upper lobe has a higher frequency of 2R/4R.…”

Section: Non-bronchus/peripheral and Clinicopathologic Featuresmentioning

confidence: 99%

Primary tumor location in lung cancer: the evaluation and administration

Xie

Tang

et al. 2021

Chinese Medical Journal

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Lung cancer continues to be the leading cause of cancer-related death in the world, which is classically subgrouped into two major histological types: Non-small cell lung cancer (NSCLC) (85% of patients) and small-cell lung cancer (SCLC) (15%). Tumor location has been reported to be associated with the prognosis of various solid tumors. Several types of cancer often occur in a specific region and are more prone to spread to predilection locations, including colorectal cancer, prostate cancer, gastric cancer, ovarian cancer, cervical cancer, bladder cancer, lung tumor, and so on. Besides, tumor location is also considered as a risk factor for lung neoplasm with chronic obstructive pulmonary disease/emphysema. Additionally, the primary lung cancer location is associated with specific lymph node metastasis. And the recent analysis has shown that the primary location may affect metastasis pattern in metastatic NSCLC based on a large population. Numerous studies have enrolled the “location” factor in the risk model. Anatomy location and lobe-specific location are both important in prognosis. Therefore, it is important for us to clarify the characteristics about tumor location according to various definitions. However, the inconsistent definitions about tumor location among different articles are controversial. It is also a significant guidance in multimode therapy in the present time. In this review, we mainly aim to provide a new insight about tumor location, including anatomy, clinicopathology, and prognosis in patients with lung neoplasm.

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Section: Non-bronchus/peripheral and Clinicopathologic Featuresmentioning

confidence: 99%

Primary tumor location in lung cancer: the evaluation and administration

Xie

Tang

et al. 2021

Chinese Medical Journal

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“…For right upper lobe tumours, we often will evaluate and/or sample first station 7 followed by 2R and 4R; stations 2R, 4R followed by 7 for right middle and right lower lobes' tumours. For left upper lobe tumours, the order is station 7 followed by 2L/4L; stations 2L/4L followed by station 7 for left lower lobe malignancies [31][32][33].…”

Section: Key Pointsmentioning

confidence: 99%

Lung cancer staging, the established role of bronchoscopy

Marshall

Kalanjeri

Almeida

2021

Current Opinion in Pulmonary Medicine

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Purpose of reviewLung cancer is the leading cause of cancer-related deaths worldwide. In the absence of distant metastases, accurate mediastinal nodal staging determines treatment approaches to achieve most favourable outcomes for patients. Mediastinal staging differentiates N0/N1 disease from N2/N3 in surgical candidates. Likewise, presence of nodal involvement in nonsurgical candidates who are being considered for stereotactic body radiation therapy is also critical. This review article seeks to discuss the current options available for mediastinal staging in nonsmall cell lung cancer (NSCLC), particularly the role of bronchoscopy. Recent findingsAlthough several techniques are available to stage the mediastinum, bronchoscopy with EBUS-TBNA with or without EUS-FNA appears to be superior in most clinical situations based on its ability to concomitantly diagnose and stage at once, safety, accessibility to the widest array of lymph node stations, cost and low risk of complications. However, training and experience are required to achieve consistent diagnostic accuracy with EBUS-TBNA. SummaryEBUS-TBNA with or without EUS-FNA is considered the modality of choice in the diagnosis and staging of NSCLC in both surgical and nonsurgical candidates.

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“…The lung is a highly immunological organ rich in multiple stations of draining lymph nodes. 8 , 9 Paradoxically, tumor cells metastasizing to TDLNs have been frequently observed, either macroscopically or microscopically, in surgically-resected lung cancer cases despite the absence of detectable distant dissemination, 10 and the presence of metastatic TDLNs is also proposed as a strong dismal prognosis factor. 11 Consistently, previous preclinical models and recent single-cell-based lineage tracing analyses support the local lymphatic system as an early metastatic route of lung cancer, prior to distant metastasis.…”

Section: Introductionmentioning

confidence: 99%