Metastatic pituitary neuroendocrine neoplasms: A case report of a malignant prolactinoma

Manique, Inês; Amaral, Sara; Rego, Teresa; Coelho, Andreia; Ponte, Andreia; Brito, Margarida; Palha, Ana; Cortez, Luísa; Forte, Dalila; Sagarribay, Amets; Cerqueira, Luís; Pontinha, Carlos; Mafra, Manuela; Silva‐Nunes, José

doi:10.1002/ccr3.8595

Clinical Case Reports

2024

DOI: 10.1002/ccr3.8595

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Metastatic pituitary neuroendocrine neoplasms: A case report of a malignant prolactinoma

Inês Manique,

Sara Amaral,

Teresa Rego

et al.

Abstract: Key Clinical MessageWe report a rare clinical case of a malignant prolactinoma in which the exponential increase of prolactin levels with minimal tumor growth and no response to treatment led to diagnosis of abdominal, thoracic, and vertebral metastases.

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Prolactin Secreting Pituitary Carcinoma and the Role of Peptide Receptor Radionuclide Therapy: A Brief Report

Agarwal,

Verma,

Gopinathan

et al. 2024

Neurology India

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Pituitary carcinoma is a rare entity comprising 0.1–0.2% of all pituitary tumors and presents significant diagnostic and therapeutic challenges. Intraspinal drop metastasis in these tumors is even rarer. We report a case of a prolactin secreting pituitary carcinoma with intracranial metastasis and multiple intraspinal drop metastasis. This is the first case where 68Gallium labelled [1,4,7,10 – tetraazacyclododecane – 1,4,7,10 – tetraacetic acid] -1- NaI3 - octreotide (68Ga-DOTANOC) whole-body positron emission tomography–computed tomography (PET-CT) has been used in a case of malignant prolactinoma, in an attempt to ascertain the somatostatin receptor (SSTR) expression on tumor cells. Through this paper, we suggest that SSTR targeted radionuclide therapy could have a potential role in aggressive pituitary tumors and pituitary carcinomas similar to the promising role of lutetium-labelled peptides in inoperable or metastasized gastroentero-pancreatic neuroendocrine tumors (GEP-NETs).

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Prolactin Secreting Pituitary Carcinoma and the Role of Peptide Receptor Radionuclide Therapy: A Brief Report

Agarwal,

Verma,

Gopinathan

et al. 2024

Neurology India

View full text Add to dashboard Cite

show abstract

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Metastatic pituitary neuroendocrine neoplasms: A case report of a malignant prolactinoma

Abstract: Key Clinical MessageWe report a rare clinical case of a malignant prolactinoma in which the exponential increase of prolactin levels with minimal tumor growth and no response to treatment led to diagnosis of abdominal, thoracic, and vertebral metastases.

Cited by 1 publication

References 23 publications

Prolactin Secreting Pituitary Carcinoma and the Role of Peptide Receptor Radionuclide Therapy: A Brief Report

Prolactin Secreting Pituitary Carcinoma and the Role of Peptide Receptor Radionuclide Therapy: A Brief Report

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