Metastatic Potential of Colon Carcinoma

Hoff, Stuart D.; Irimura, Tatsuro; Matsushita, Yosuke; Ota, David M.; Cleary, Karen R.; Hakomori, Sen‐itiroh

doi:10.1001/archsurg.1990.01410140084013

Cited by 58 publications

(2 citation statements)

References 22 publications

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“…Hoff et al reported that the adhesion of cancer cells to vascular endothelial cells is considered to be a key step in tumor cell extravasation 1, 2 , Kobayashi et al 17 clarified that metastasis is inhibited by the prevention of cancer cell adhesion to the endothelial cells because of the blocking E-selectin expression, and Kannagi 3 proposed that inhibiting the expression of P-, E-, and L-selectins induces a blockade of metastasis. We speculate that pranlukast suppresses expression of all selectins on the vascular endothelial cells, thereby inhibiting tumor cell adhesion and extravasation.…”

Section: Discussionmentioning

confidence: 99%

“…Since it has been reported that the adhesion of cancer cells to vascular endothelial cells is a key step in tumor cell extravasation 1, 2 , many studies have focused on the inhibition of the binding of sialyl Lewis x and sialyl Lewis a antigen with E- and P-selectins on the activated endothelium by using competitive ligand inhibitors, metabolic carbohydrate mimetics, or neutralizing monoclonal antibodies. However, these efforts have not yet produced any fruitful results.…”

Section: Introductionmentioning

confidence: 99%

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Cysteinyl Leukotriene Receptor Antagonists Inhibit Tumor Metastasis by Inhibiting Capillary Permeability

Nozaki

Yoshikawa

Ishitani³

et al. 2010

Keio J. Med.

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We explored the possibility of the cysteinyl leukotriene receptor antagonists, pranlukast and montelukast, preventing tumor cell migration through both cerebral and peripheral capillaries. To study tumor cell migration through brain capillaries, male Fisher rats were cannulated via the cisterna magna under pentobarbital anesthesia. RCN9 cells labeled with a fluorescent marker PKH67 were intravenously administered following arachidonic acid administration into the subarachnoid space, and specimens of the central nervous system were collected every 30 min for 8 h. Arachidonic acid increased the fluid volume with elevated white blood cell and RCN9 cell counts. When given 2 h before arachidonic acid administration, pranlukast, but not montelukast, reduced the fluid volume and inhibited white blood cell and RCN9 cell extravasation through the brain capillary. In addition, a Lewis lung carcinoma metastasis model in mice was used to study the inhibitory effect of pranlukast and montelukast against cancer cell extravasation through general capillaries. When mice were given food containing either pranlukast or montelukast, immediately after paw amputation, tumor metastasis was prevented by both drugs, and their survival was prolonged. These results show that pranlukast can inhibit tumor cell migration through both the brain and peripheral capillaries, whereas montelukast inhibits tumor cell migration only in the peripheral capillaries.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cysteinyl Leukotriene Receptor Antagonists Inhibit Tumor Metastasis by Inhibiting Capillary Permeability

Nozaki

Yoshikawa

Ishitani³

et al. 2010

Keio J. Med.

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Adhesion of Head and Neck Squamous Cell Carcinoma to Endothelial Cells: The Missing Links

Wenzel

Scher²,

Richtsmeier³

1995

Archives of Otolaryngology - Head and Neck Surgery

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Review Article. Cell Surface Carbohydrates as Prognostic Markers in Human Carcinomas

Dabelsteen

1996

J. Pathol.

215

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Tumour development is usually associated with changes in cell surface carbohydrates. These are often divided into changes related to terminal carbohydrate structures, which include incomplete synthesis and modification of normally existing carbohydrates, and changes in the carbohydrate core structure. The latter includes chain elongation of both glycolipids and proteins, increased branching of carbohydrates in N‐linked glycoproteins, and blocked synthesis of carbohydrates in O‐linked mucin‐like glycoproteins. In mature organisms, expression of distinct carbohydrates is restricted to specific cell types; within a given tissue, variation in expression may be related to cell maturation. Tumour‐associated carbohydrate structures often reflect a certain stage of cellular development; most of these moieties are structures normally found in other adult or embryonic tissues. There is no unique tumour carbohydrate structure, since certain structures which are tumour‐related in one organ may be normal constituents of other tissues. Tumour‐associated carbohydrate changes have been used in the diagnosis of human cancers. Recently, however, it has been demonstrated that the expression of some carbohydrate structures is associated with prognosis. Tn, sialyl‐Tn, and T are cell membrane‐bound mucin‐like carbohydrate structures that may be expressed in tumours due to blocked synthesis of the core carbohydrate chain of mucin‐like structures. Their expression is strongly associated with prognosis in certain tumours, but the biological relationship between their expression and tumour progression is at present unknown. The blood group‐related carbohydrate structures Lex, sialyl‐Lex, ABH, and Ley are examples of terminal carbohydrate structures which are related to tumour prognosis. These structures are of increasing interest since they may function as adhesion molecules; adhesion of tumour cells to endothelial cells of blood vessels may be mediated by an interaction between sialosyl‐Lex and E‐selectin and studies indicate that Ley is related to cell motility. These findings are now the basis for tumour therapeutic experiments.

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Metastatic Potential of Colon Carcinoma

Cited by 58 publications

References 22 publications

Cysteinyl Leukotriene Receptor Antagonists Inhibit Tumor Metastasis by Inhibiting Capillary Permeability

Cysteinyl Leukotriene Receptor Antagonists Inhibit Tumor Metastasis by Inhibiting Capillary Permeability

Adhesion of Head and Neck Squamous Cell Carcinoma to Endothelial Cells: The Missing Links

Review Article. Cell Surface Carbohydrates as Prognostic Markers in Human Carcinomas

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