Metastatic Prostate Adenocarcinoma Diagnosed in a Colonic Polyp

Steevens, Christopher; Abraham, James; Bahadur, Sandeep

doi:10.1200/jco.2011.39.7489

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…After reviewing the 35 articles previously described in “Patient population,” we found 22 suitable articles with clinical description of prostate cancer with rectal involvement. Of these 22 suitable reference articles, 11 case reports [7-10,13-20] (with 28 cases) were in English, 5 in Japanese [21-25] (with 7 cases), and 2 in Portuguese Language [26,27] (with 2 cases), with a total of 37 cases being identified. We also found 3 review articles in Japanese [28-30] (with 47 cases).…”

Section: Resultsmentioning

confidence: 99%

Factors associated with the survival of prostate cancer patients with rectal involvement

Wang

Yao

2014

Diagn Pathol

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BackgroundProstate cancer patients with rectal involvement are rare, and the factors associated with the survival of these patients are yet to be elucidated.Patients and methodsWe collected data on patients who were admitted to our hospital for prostate cancer in the last thirteen years and of those in studies in the literature. The associations of clinical characteristics with survival were evaluated using Cox regression models.ResultsThis study included 94 patients (5 admitted to our hospital and 89 from studies in the literature) of prostate cancer with rectal involvement. 11 patients in the group of synchronous rectal involvement at first cancer diagnosis (n = 58) and 23 patients in the group of metachronous diagnosis of rectal involvement (n = 29) died at the latest follow up. The estimated overall survival rate (% ± SE) at 1, 3, and 5 years were 68.3 ± 5.3%, 54.4 ± 7.2%, and 38.1 ± 11.1%, respectively. In the Cox univariate analysis, Asian prostate cancer (p = 0.001) was associated with better survival, while rectal bleeding (p = 0.043), metachronous presentation of development of rectal involvement (p = 0.000), prior hormonal therapy (p = 0.000) and extrarectal metastases (p = 0.054) were associated with poor survival. In multivariate analysis, prior hormone therapy (HR = 14.540, p = 0.000) and rectal bleeding (HR = 2.195, p = 0.041) retained independent poor prognostic values. There were 13 patients survived for more than 3 years, the longest survival time was 96 months. Total pelvic extenteration (TPE) combined with hormonal therapy in 12 hormone-untreated prostate cancer give us six of thirteen long-term survivors for more than 3 years in this series.ConclusionsOur findings suggest that rectal involvement does not necessarily predict a worse outcome when presenting as a previously hormone-untreated disease and that the prognosis was worse when presenting as a hormone relapsed disease. Prior hormone therapy and rectal bleeding were associated independently with a significantly poor overall survival in prostate cancer patients with rectal involvement. TPE combined with hormonal therapy appears to confer better overall survival in hormonally untreated patients.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1604504118106105.

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Section: Resultsmentioning

confidence: 99%

Factors associated with the survival of prostate cancer patients with rectal involvement

Wang

Yao

2014

Diagn Pathol

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“…Because several cases of extracolonic cancer have presented as colorectal polyps, consideration of a wide range of differential diagnoses is warranted [10]. Delicate histologic differences between prostate and rectal cancers could facilitate accurate diagnoses.…”

Section: Discussionmentioning

confidence: 99%

Rectal Invasion by Prostatic Adenocarcinoma That Was Initially Diagnosed in a Rectal Polyp on Colonoscopy

Yoon

Han

Seo³

2019

J Pathol Transl Med

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Despite anatomical proximity, prostatic adenocarcinoma with rectal invasion is extremely rare. We present a case of rectal invasion by prostatic adenocarcinoma that was initially diagnosed from a rectal polyp biopsied on colonoscopy in a 69-year-old Korean man. He presented with dull anal pain and voiding discomfort for several days. Computed tomography revealed either prostatic adenocarcinoma with rectal invasion or rectal adenocarcinoma with prostatic invasion. His tumor marker profile showed normal prostate specific antigen (PSA) level and significantly elevated carcinoembryonic antigen level. Colonoscopy was performed, and a specimen was obtained from a round, 1.5 cm, sessile polyp that was 1.5 cm above the anal verge. Microscopically, glandular tumor structures infiltrated into the rectal mucosa and submucosa. Immunohistochemically, the tumor cells showed alpha-methylacyl-CoA-racemase positivity, PSA positivity, and caudal-related homeobox 2 negativity. The final diagnosis of the rectal polyp was consistent with prostatic adenocarcinoma. Here, we present a rare case that could have been misdiagnosed as rectal adenocarcinoma.

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“…Polyps harboring metastasis from extra-colonic cancers have been reported in patients with breast, ovarian, skin (melanoma), gastric, esophageal and renal cancer [2,12]. From our review of published cases of lung cancer metastatic to the GI tract only two report metastatic deposits in colonic polyps [2,4].…”

Section: Discussionmentioning

confidence: 99%

Non-small Cell Lung Cancer with Squamous Features Metastatic to a Colonic Polyp: A Case Report of a Very Rare Presentation

Bukamur

Saad

Shahoub

et al. 2019

Cureus

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Among all malignant diseases, lung cancer is the most common on a worldwide basis. It is usually discovered incidentally on lung imaging studies or because of symptoms. The diagnosis is confirmed on biopsy material from the primary malignancy or from metastatic deposits. This is a report of metastatic lung cancer with squamous features discovered in an endoscopically removed colonic polyp. To our knowledge, there are only two prior reports of lung cancer being diagnosed in colonic polyps. We could not find any reports of lung cancer with squamous features metastatic to a colon polyp. In this case, the carcinoma was found in a polyp removed from a patient who presented with severe anemia and melena.

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Metastatic Prostate Adenocarcinoma Diagnosed in a Colonic Polyp

Cited by 5 publications

References 18 publications

Factors associated with the survival of prostate cancer patients with rectal involvement

Factors associated with the survival of prostate cancer patients with rectal involvement

Rectal Invasion by Prostatic Adenocarcinoma That Was Initially Diagnosed in a Rectal Polyp on Colonoscopy

Non-small Cell Lung Cancer with Squamous Features Metastatic to a Colonic Polyp: A Case Report of a Very Rare Presentation

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