Metastatic prostate adenocarcinoma presenting with pulmonary symptoms: a case report and review of the literature

Tohfe, Moustapha; Baki, Samah G. Abdel; Saliba, Wissam; Ghandour, Fatmeh; Ashou, Raja; Ghazal, Georges; Bahous, Joudy; Chamseddine, Nabil

doi:10.1186/1757-1626-1-316

Cited by 11 publications

(9 citation statements)

References 9 publications

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“…Pulmonary metastasis commonly develops in prostate cancer patients who have bone metastasis [ 48 ]. We found a significant reduction in lung metastasis in vivo with both genetic and pharmacological inhibition of ERα in tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Estrogen and estrogen receptor alpha promotes malignancy and osteoblastic tumorigenesis in prostate cancer

Mishra

Qin

et al. 2015

Oncotarget

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The role of estrogen signaling in regulating prostate tumorigenesis is relatively underexplored. Although, an increasing body of evidence has linked estrogen receptor beta (ERβ) to prostate cancer, the function of estrogen receptor alpha (ERα) in prostate cancer is not very well studied. We have discovered a novel role of ERα in the pathogenesis of prostate tumors. Here, we show that prostate cancer cells express ERα and estrogen induces oncogenic properties in prostate cancer cells through ERα. Importantly, ERα knockdown in the human prostate cancer PacMetUT1 cells as well as pharmacological inhibition of ERα with ICI 182,780 inhibited osteoblastic lesion formation and lung metastasis in vivo. Co-culture of pre-osteoblasts with cancer cells showed a significant induction of osteogenic markers in the pre-osteoblasts, which was attenuated by knockdown of ERα in cancer cells suggesting that estrogen/ERα signaling promotes crosstalk between cancer and osteoblastic progenitors to stimulate osteoblastic tumorigenesis. These results suggest that ERα expression in prostate cancer cells is essential for osteoblastic lesion formation and lung metastasis. Thus, inhibition of ERα signaling in prostate cancer cells may be a novel therapeutic strategy to inhibit the osteoblastic lesion development as well as lung metastasis in patients with advanced prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Estrogen and estrogen receptor alpha promotes malignancy and osteoblastic tumorigenesis in prostate cancer

Mishra

Qin

et al. 2015

Oncotarget

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“…In a review of published reports, there were a few other cases of SVC syndrome or intrathoracic lymphadenopathy with prostate cancer,5 – 12 but in these cases the histopathology typically was described as being that of a poorly or moderately differentiated carcinoma, rather than the well-differentiated adenocarcinoma, as reported in our case. The mechanisms of metastasis are complex and incompletely understood, but it is apparent from our case that a favourable histology alone does not preclude widespread and aggressive metastatic disease.…”

Section: Discussionmentioning

confidence: 48%

Superior vena cava syndrome as a presentation of metastatic prostate cancer

Yun

Ershler

2012

BMJ Case Reports

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SummarySuperior vena cava (SVC) syndrome is an uncommon complication of malignant disease caused by the obstruction of venous blood flow in the SVC. When present, a diagnosis of lung cancer or lymphoma will be made in approximately 95% of cases. Although other malignant diseases are occasionally associated with SVC, its occurrence in patients with prostate cancer is rare. We present a case of a patient presenting with SVC obstruction who was subsequently diagnosed with prostate adenocarcinoma. The patient has been successfully treated with GnRH agonist. This case reflects the importance of a full clinical assessment and pathological confirmation of suspected tumour prior to treatment. BACKGROUND

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“…In addition to the rarity of lung metastasis, initial presentation of prostatic adenocarcinoma as a pulmonary primary lesion is rare. [ 5 ] Tohfe et al . recently described a patient with a similar presentation who was found to have prostatic adenocarcinoma metastatic to the lung diagnosed on a trucut biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…recently described a patient with a similar presentation who was found to have prostatic adenocarcinoma metastatic to the lung diagnosed on a trucut biopsy. [ 5 ] Diagnosis of metastatic prostatic adenocarcinoma on cytologic material (i.e., BAL specimen) is uncommon and difficult. In 1991, Verstraeten et al .…”

Section: Discussionmentioning

confidence: 99%

Metastatic prostatic adenocarcinoma diagnosed in a bronchoalveolar lavage specimen: An unusual presentation of a common tumor

Moul

Rojas

Kovacs

et al. 2016

J Cytol

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Metastatic prostatic adenocarcinoma presenting as a primary lung disease is rare. We present a 52-year-old male with a 3-month history of cough, shortness of breath, and weight loss with clinical and radiological findings suggestive of a primary lung disease: Bilateral interstitial and alveolar opacities with blunting of the costophrenic angles, multiple diffuse foci of consolidations and nodules, predominantly subpleural and located in the lower lobes, and diffuse interlobular septal thickening and peribronchial thickening. The patient underwent bronchoscopy and bronchoalveolar lavage (BAL) was obtained. Cytospin smears were diagnostic for a low-grade adenocarcinoma. Clinically, the patient had elevated serum prostate-specific antigen (PSA) levels greater than 5,000 ng/mL. Because of this, immunocytochemistry for PSA was performed which was positive, confirming the diagnosis of metastatic prostatic adenocarcinoma. This unusual case of metastatic adenocarcinoma of the prostate first diagnosed by BAL highlights the significance of available clinical information and the use of immunocytochemistry for proper diagnosis.

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Metastatic prostate adenocarcinoma presenting with pulmonary symptoms: a case report and review of the literature

Cited by 11 publications

References 9 publications

Estrogen and estrogen receptor alpha promotes malignancy and osteoblastic tumorigenesis in prostate cancer

Estrogen and estrogen receptor alpha promotes malignancy and osteoblastic tumorigenesis in prostate cancer

Superior vena cava syndrome as a presentation of metastatic prostate cancer

Metastatic prostatic adenocarcinoma diagnosed in a bronchoalveolar lavage specimen: An unusual presentation of a common tumor

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