Metastatic prostate cancer incidence in Australia after amendment to prostate‐specific antigen screening guidelines

Smith, Sabin; Wolanski, Philippe

doi:10.1111/ans.14275

Cited by 10 publications

(11 citation statements)

References 23 publications

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“…Accurately sampling the prostate during biopsy has become increasingly important amidst concerns that men are presenting later and with more advanced disease as a result of the recommendations against routine PSA screening released in 2012 …”

Section: Discussionmentioning

confidence: 99%

“…There are limited published studies reporting anatomical correlation between lesions with a high PI‐RADS and IL at RP histopathology . One retrospective study comparing cognitive‐fusion biopsy of 63 patients with robotic RP whole‐mount pathology found MRI was anatomically accurate in 73% of cases .…”

Section: Discussionmentioning

confidence: 99%

“…mpMRIs were performed at a single centre using the Discovery MR750w 3.0T (GE Healthcare, Chicago, IL, USA), 3‐Tesla magnet and a standardized protocol as per published mpMRI prostate studies …”

Section: Methodsmentioning

confidence: 99%

“…Over the last 10 years, multiparametric magnetic resonance imaging (mpMRI) of the prostate has emerged as a tool for the assessment and diagnosis of focal prostate cancer (PCa), especially amidst concerns about the accuracy of screening measures …”

Section: Introductionmentioning

confidence: 99%

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Accuracy of multiparametric magnetic resonance imaging to detect significant prostate cancer and index lesion location

Goldman

Singh

Harding

et al. 2018

ANZ Journal of Surgery

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Background: Multiparametric magnetic resonance imaging (mpMRI) of the prostate appears to improve prostate cancer detection, but studies comparing mpMRI to histopathology at the time of radical prostatectomy (RP) are lacking. This retrospective study determined the accuracy of mpMRI predicting Gleason score and index lesion location at the time of RP, the current gold standard for diagnosis. Methods: Between April 2013 and April 2016, a database of all men aged more than 40 years who underwent RP after positive transrectal ultrasound biopsy by an experienced urological surgeon was collated at a single regional centre. This was cross-referenced with a database of all men who had mpMRIs performed at a single centre and reported according to Prostate Imaging Reporting and Data System (PI-RADS version 1) during this period to generate a sample size of 64 men. A Spearman's rho test was utilized to calculate correlation. Results: Median age of patients was 64 years, the median prostate-specific antigen at RP was 6.22 ng/mL. mpMRI was positive (≥PI-RADS 3) in 85.9% of patients who underwent RP. More than 92% of participants had Gleason ≥7 disease. A positive relationship between mpMRI prostate PI-RADS score and RP cancer volume was demonstrated. An anatomical location correlation calculated in octants was found to be 89.1% accurate. Conclusion: mpMRI accurately detects prostate cancer location and severity when compared with gold standard histopathology at the time of RP. It thus has an important role in planning for future prostate biopsy and cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Accuracy of multiparametric magnetic resonance imaging to detect significant prostate cancer and index lesion location

Goldman

Singh

Harding

et al. 2018

ANZ Journal of Surgery

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“…Bone metastasis is a major cause of the mortality of PCa patients, which requires the communication between PCa cells and the metastatic microenvironment [3,4]. Therefore, understanding the molecular mechanism underlying the interaction between PCa cells and osteoblasts will be crucial for developing novel therapeutic strategies against metastatic PCa.…”

Section: Introductionmentioning

confidence: 99%

Prostate Cancer-Secreted Exosomal miR-1275 Modulates Osteoblast Proliferation and Differentiation by Targeting SIRT2/RUNX2 Cascade

Zou¹,

Dai²,

Deng³

et al. 2020

Preprint

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BackgroundCancer-derived exosomes can promote tumor metastasis by delivering miRNAs from cancer cells to recipient cells. miR-1275 is suggested to be an important regulator involved in prostate cancer (PCa) metastasis; however, the association of miR-1275 with the microenvironment of PCa bone metastasis is unclear.Materials and methodsThe level of relative genes and proteins were detected by qPCR and western-blot, cell ability were examined by CCK-8 , the identification of target gene was analyzed by dual-luciferase reporter assay,exosomes were isolated from the PC3-derived conditioned medium by ultracentrifugation.Resultwe found that miR-1275 could be transferred from PCa cells to osteoblasts via exosomes. Exosomal miR-1275 significantly accelerated the proliferation of osteoblasts and the expression levels of osteoblast-specific genes, such as osteocalcin (OCN), type I collagen (COL-1), and osteopontin (OPN). Moreover, exosomal miR-1275 increased the expression of RUNX2, a master modulator of osteoblast differentiation, by down-regulation of SIRT2, which in turn influenced the proliferation and differentiation of osteoblasts.ConclusionsOur findings indicate that exosomal miR-1275 is a promoter of osteoblast activity, which may contribute to PCa bone metastasis.

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Trends in Incidence of Metastatic Prostate Cancer in the US

et al. 2022

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IMPORTANCEThe US Preventive Services Task Force (USPSTF) has recommended against routine prostate-specific antigen (PSA)-based prostate cancer (PCa) screening, initially for men older than 75 years in 2008, and then for all men in 2012. Concern has been raised that, by recommending against screening, and thus early detection, the USPSTF recommendations may be associated with an increase in the incidence of metastatic PCa (mPCa). OBJECTIVE To explore the incidence of mPCa before and after the USPSTF recommendations against routine PCa screening. DESIGN, SETTING, AND PARTICIPANTSThis population-based cohort study used the recently released Surveillance, Epidemiology, and End Results (SEER) 18 registry incidence data to identify men aged 45 years and older with a diagnosis

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Metastatic prostate cancer incidence in Australia after amendment to prostate‐specific antigen screening guidelines

Abstract: The incidence of newly diagnosed metastatic prostate cancer nearly doubled in patients referred to our Urology Department post-release of the USPSTF guidelines.

Cited by 10 publications

References 23 publications

Accuracy of multiparametric magnetic resonance imaging to detect significant prostate cancer and index lesion location

Accuracy of multiparametric magnetic resonance imaging to detect significant prostate cancer and index lesion location

Prostate Cancer-Secreted Exosomal miR-1275 Modulates Osteoblast Proliferation and Differentiation by Targeting SIRT2/RUNX2 Cascade

Trends in Incidence of Metastatic Prostate Cancer in the US

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