Metastatic prostate cancer to the duodenum: A rare case

Abstract

Prostate cancer is the third most common cancer in man. About 1 in 6 males developed prostate cancer and 1 in 35 males die of this disease. Prostate cancer behavior ranges from microscopic tumors to aggressive cancer with metastatic potential. While metastasis to bone is relatively common, prostate cancer rarely metastasizes to the cecum, pituitary gland, small bowel, maxillary sinus and skin. Our case report presents a rare presentation of metastatic prostate cancer to the duodenum. Our search of the literature found only 2 cases of prostate metastases to duodenum published from 1966 to the present. To our knowledge this is the third case of metastatic prostate cancer presenting with duodenal metastasis. Although it is rare but in symptomatic patients small intestine metastasis should not be ignored with advanced prostate cancer. The case demonstrates a novel presentation of a common malignancy, and should raise awareness in clinicians and radiologists that prostate cancer can present with distant metastases in absence of any local lymphadenopathy.

Unusual small bowel metastatic localization in a castration-resistant prostate cancer patient

“…A retrospective study of 359 CRPC patients found that visceral metastases were detected by the last imaging evaluation before death in 32% of cases, and in 49% of the patients who underwent a radiographic assessment within 3 months of death [4], thus further confirming that visceral metastases are usually related to advanced disease. To the best of our knowledge, only three cases of small bowel metastases from prostate cancer have been reported in the last 40 years [12][13][14]. In the case observed by Lee et al endoscopic findings of a solitary tumor lesion in the duodenum and the close proximity of the small bowel to known liver metastases and pathological retroperitoneal lymph nodes, suggested possible direct infiltration rather than a lymphatic or hematogenous spread of the primary tumor [12].…”

Prostate cancer metastasis to the distal phalanx of the left hallux: The first confirmed case and literature review

“…Although cutaneous metastasis from prostate cancer is rare in the literature, it has recently been reported in a large number of the case studies (Table I) (8)(9)(10)(11). In addition, the iris (12), gastrointestinal tract (13), parotid gland (14), proximal ureter (15), duodenum (16), intramedullary spinal cord (17), larynx (18) and mandibular condyle (19) are also involved metastatic sites of prostate cancer. Nonetheless, prostate cancer with metastasis to the phalanx of the toe has been not reported to date.…”

Duodenum Metastasıs of Prostate Cancer: A Rare Case Presentatıon

“…The frequency of metastasis to the duodenum is highest in lung cancer, renal cell carcinoma, malignant melanoma, and breast cancer (14). There are a limited number of case reports of duodenum metastasis in prostate cancer.…”

“…There are a limited number of case reports of duodenum metastasis in prostate cancer. Duodenum metastasis was reported in three patients between 1966 and 2014 (14). The diagnosis of duodenum metastases can be challenging.…”

“…Gastrointestinal system (GIS) involvement has been also reported as case presentations (8)(9)(10)(11)(12)(13). Until 2014, duodenum metastasis was reported in three patients (14). Herein, we aimed to present a patient who had widespread bone metastasis, as well as isolated duodenum metastasis at diagnosis.…”