Metastatic renal cell carcinoma involving colon with unusual histologic features and diagnostic challenges: A case report

Saadaat, Ramin; Haidary, Ahmed Maseh; Ibrahimkhil, Abdul Sami; Abdul‐Ghafar, Jamshid

doi:10.1016/j.ijscr.2021.02.013

Cited by 7 publications

(10 citation statements)

References 20 publications

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“…Based on the literature, it is unusual for renal cell cancer to spread to the gut, but when it does metastasize, it can affect any part of the gastrointestinal tract. However, colonic metastasis is less common than metastasis to small bowel and stomach [ 3 ]. There is no distinct hematogenous or lymphatic route that could adequately explain the spread of RCC to the colon.…”

Section: Discussionmentioning

confidence: 99%

“…Renal cell carcinoma (RCC) is a primary kidney tumor with a mortality of up to 40%, which is the highest among all genitourinary cancers [ 1 ]. Among the various histologic subtypes of RCC, clear cell cancer is the predominant one, accounting for 75-80% of all cases [ 2 , 3 ]. Metastatic disease is frequently present in patients with RCC, being diagnosed in almost 25% of patients [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Descending Colon Metastasis of Renal Cell Carcinoma: An Unusual Site of Metastasis

Alvi,

Tchouambou Pougoue,

Summers-Powell

et al. 2024

Cureus

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Renal cell carcinoma (RCC) has a high metastatic potential. While metastasis to common sites like the lungs, liver, bones, and brain is well-documented, metastasis to the colon, particularly the descending colon, remains an uncommon occurrence. When RCC does metastasize to the gastrointestinal tract, it commonly spreads to the small bowel and stomach. There are few cases reported in literature involving RCC metastasis to the colon. The commonly affected areas within the colon include the rectosigmoid colon, splenic flexure, and transverse colon. We describe an 87-year-old male with a history of stage III RCC diagnosed three years ago, followed by left-sided nephroureterectomy, partial adrenalectomy, and perinephric lymph node dissection. He presented to the emergency department (ED) with melena and generalized abdominal pain for one week. Stool occult blood was positive. Computed tomography (CT) of the abdomen was significant for stable postsurgical changes related to prior left nephrectomy and colonic mass at the proximal descending colon. A colonoscopy revealed a necrotic appearing friable mass in the descending colon. The pathology of the mass revealed proliferated atypical cells positive for paired box 8 (PAX8), a cluster of differentiation 10 (CD10), RCC, and pan-cytokeratin and negative for caudal-type homeobox 2 (CDX2), thyroid transcription factor-1 (TTF-1), and a cluster of differentiation 68 (CD68), consistent with metastatic RCC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Descending Colon Metastasis of Renal Cell Carcinoma: An Unusual Site of Metastasis

Alvi,

Tchouambou Pougoue,

Summers-Powell

et al. 2024

Cureus

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“…They are described as solitary or with concomitant involvement of other organs (brain and lungs) as in this case. GI tract organ affection includes the duodenum [ 9 , 11 ], the colon [ 12 ], the rectum [ 3 ], and the anal canal [ 9 , 10 ]. To the best of our knowledge, the present case is the third report on the occurrence of anal canal metastasis originating from RCC ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Bleeding metastasis of renal cell cancer to anal canal treated with radiation

Ulusoy,

Mete,

Nikolovski

2023

Radiat Oncol J

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Renal cell cancer (RCC) has the ability to metastasize to various organs, including the anal canal which is reported to be the rarest location. An 88-year-old male patient who had previously been treated for right RCC subsequently developed distant metastases to the prostate, lungs, and small bowel. Four years following nephrectomy, the patient presented with a bleeding anal mass which was excised and has been proven to be an anal canal metastasis of RCC. Eight months post excision, regrowth occurred. The patient underwent stereotactic ablative body radiotherapy resulting in satisfactory regression during the 2-month follow-up period, without episodes of bleeding. The treatment options for metastatic post-nephrectomy disease should be considered with a multidisciplinary approach in order to achieve satisfactory symptom relief.

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“…Histologically, rhabdoid cells are characterized by large polygonal cells with large amount pink-eosinophilic cytoplasm and having pleomorphic eccentric nuclei with visible large nucleoli. On IHC staining, rhabdoid cells show positive reactivity with vimentin, epithelial membrane antigen (EMA), cytokeratins and PAX8 but not reactive for desmin, myoglobin, myogenin and Myo D1 [ 4 , 50 ]. To the best of our knowledge no case of metastatic RCC with rhabdoid features has been reported in literature and our case represents the first case of RCC with rhabdoid features metastasizing to colon.…”

Section: Discussionmentioning

confidence: 99%

Metastatic renal cell carcinoma to pancreas and gastrointestinal tract: a clinicopathological study of 3 cases and review of literature

et al. 2021

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Background Renal Cell Carcinoma (RCC) metastasizes in approximately 20–30% cases. The most common sites for metastases are the lungs, bones, liver, and brain. Metastases of RCC in the gastrointestinal tract (GIT) are very rare. Metastatic RCC has a poor prognosis. We herein present a case series of three patients with metastatic disease in the colon, duodenum, and pancreas following complete resection of RCC. Methods Hematoxylin and Eosin and immunohistochemical slides of 3 cases of RCC metastatic to GIT were reviewed. These cases were diagnosed between 2002 and 2019 at French Medical Institute for Mothers and Children (FMIC), Kabul, Afghanistan, and Aga Khan University Hospital (AKUH), Karachi, Pakistan. We also present a detailed review of published literature. Results We reviewed cases of three patients, two females and one male, with a mean age of 57.3 years (range 40–67 years) who underwent nephrectomy for RCC. They developed metastases in the colon, pancreas, and duodenum, respectively 12–168 months (median time 156 months) following primary tumor resection. The patient with metastatic RCC in colon presented with abdominal pain and constipation. An ulcerated mass was found on colonoscopy 30 cm from the anal verge. Diagnosis of RCC with rhabdoid features was confirmed in both primary and metastatic tumors. The second patient developed a metastatic nodule in the head of pancreatic while the third patient developed metastatic nodules in the duodenum and pancreas which were detected by Computed Tomography (CT) scanning. Histopathological examination confirmed the presence of clear cell RCC in the metastatic nodules in both cases. Conclusion Metastatic RCC should be considered in the differential diagnosis of mass in the gastrointestinal (including pancreaticobiliary) tract especially in presence of a past history of RCC. These patients should be screened thoroughly by physical examination and appropriate imaging studies.

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Metastatic renal cell carcinoma involving colon with unusual histologic features and diagnostic challenges: A case report

Cited by 7 publications

References 20 publications

Descending Colon Metastasis of Renal Cell Carcinoma: An Unusual Site of Metastasis

Descending Colon Metastasis of Renal Cell Carcinoma: An Unusual Site of Metastasis

Bleeding metastasis of renal cell cancer to anal canal treated with radiation

Metastatic renal cell carcinoma to pancreas and gastrointestinal tract: a clinicopathological study of 3 cases and review of literature

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