Metastatic renal cell carcinoma to the bladder 12 years after radical nephrectomy

Shiraishi, Koji; Mohri, Jun; Inoue, Ryo; Kamiryo, Yoriaki

doi:10.1046/j.1442-2042.2003.00652.x

Cited by 26 publications

(24 citation statements)

References 8 publications

(16 reference statements)

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“…Thus, given the rarity of sporadic bilateral renal carcinoma, its management remains a challenge. In addition, urinary bladder metastasis is extremely rare, which can be synchronous [2] or metachronous [3] and less than 2% have been reported [1]. In terms of bladder metastasis from RCC, asynchronous metastasis is far more common than synchronous metastasis [5].…”

Section: Discussionmentioning

confidence: 99%

“…The lungs are the most frequent site for metastases, and nearly 20% of all patients with RCC have pulmonary metastases when first diagnosed. However, urinary bladder metastasis is extremely rare, which can be synchronous [2] or metachronous [3], and less than 2% have been reported [1]. Herein we report a synchronous metastasis of RCC to the bladder and lung.…”

Section: Introductionmentioning

confidence: 92%

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Renal cell carcionoma with synchronous metastases to the bladder and lung

Jang¹,

Hwang²,

Hwang³

et al. 2013

CRCM

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Renal cell carcinoma can metastasize to virtually any organ, yet synchronous metastasis to the bladder is extremely rare. A 77-year-old woman presented with gross hematuria. Abdominal and chest computed tomography showed a bilateral renal masses, bladder dome mass, and multiple lung metastasis. Transurethral resection of the bladder tumor and sonography guided renal biopsy were performed. Both pathology diagnoses were clear cell renal cell carcinoma. Targeted therapy using pazopanib was administered to the patient without surgical resection of primary tumors and metastatic lung lesions. Herein, we report the synchronous metastasis of renal cell carcinoma to the bladder and lung.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Renal cell carcionoma with synchronous metastases to the bladder and lung

Jang¹,

Hwang²,

Hwang³

et al. 2013

CRCM

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“…[1][2][3][4]8,[10][11][12] However, the common sites, such as lungs, liver, brain and bone, can be monitored easily and there are reports of successful resection of isolated metastases from these organs.…”

Section: Discussionmentioning

confidence: 99%

Recurrent renal cell cancer: 10 years or more after nephrectomy

Abara¹,

Chivulescu

Clerk

et al. 2013

CUAJ

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Localized renal cell carcinoma (RCC) responds well to surgery. Patients often question how long they have to be on surveillance after their surgery. Several follow-up patterns have been described in the literature. Until 2009, no published established Canadian guidelines existed to assist Canadian health-care practitioners in the surveillance of these patients. We present 3 cases of RCC that recurred 10 years or longer after the initial nephrectomy. These cases emphasize the need for careful long-term follow-up, as recommended in the Canadian Urological Association guidelines. We also discuss the optimism of prolonged disease survival in the era of novel therapeutic agents that target angiogenesis.

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“…There was no evidence of metastasis to the lungs, bones or other organs based on the normal results of relevant CT scans of the bones, abdomen and thorax. Systemic therapy, including chemotherapy and targeted therapy, for the metastatic tumors of the bladder and the left retroperitoneal space, was not administered, primarily due to a weakened performance status (Karnofsky score, <40), anemia and the unstable sugar content of the blood (11). Extensive hydrothorax and general anasarca presented half a month after transurethral resection of the bladder tumor (TURBT).…”

Section: Case Reportmentioning

confidence: 99%

“…1C), but negative for RCC and human melanoma mark black 45. Following radical surgery, neither targeted nor immunological agents were administered on the basis of the RCC treatment guidelines (11). At 1 month after the radical nephrectomy, the patient received transurethral clot evacuation and resection of a sessile tumor (1.0x1.4x1.0 cm) on the left bladder, due to the occurrence of hematuria and acute urinary clot retention (Fig.…”

Section: Case Reportmentioning

confidence: 99%

Simultaneous metastases of clear cell renal cell carcinoma to the urinary bladder and left retroperitoneal space: A case report and review of the literature

Wang

et al. 2016

Oncology Letters

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Abstract. The present study describes an extremely rare case of simultaneous metastases of clear cell renal cell carcinoma (ccRCC) to the urinary bladder and left retroperitoneal space, occurring subsequent to an open radical nephrectomy. A review of the literature is also considered. A 70-year-old man presenting with diabetes mellitus and hypertension was referred to West China Hospital (Chengdu, China) with constant left flank pain that had been apparent for 2 months. Ultrasonography identified a heterogeneous tumor with a solid component measuring 4.4x3.4x5.0 cm, and computed tomography (CT) revealed a circumscribed and contrast-enhanced tumor in the left kidney. Subsequent pathological analysis of the specimen, obtained from an open radical nephrectomy, confirmed the presence of ccRCC. At 1 month after the radical nephrectomy, an abdominopelvic CT scan identified tumors located on the posterior bladder wall and also in the left retroperitoneal space, forming due to hematuria and acute urinary clot retention. There was no evidence of metastasis to the lungs, bones or other organs. A transurethral resection of the bladder tumor was performed and pathological analysis of the bladder specimen demonstrated metastatic ccRCC. Extensive hydrothorax and general anasarca presented half a month after the transurethral resection, with the patient subsequently succumbing 15 days later. IntroductionDuring 2010, renal cell carcinoma (RCC) was estimated to account for 58,240 novel cases of the disease and 13,040 mortalities in the United States, and at present, cases are steadily increasing at a rate of 2.5% per year across population groups (1,2). Clear cell RCC (ccRCC) is one of the most common subtypes of the disease, accounting for 70-80% of all RCC cases (3). A key characteristic of kidney cancer is its tendency to metastasize widely prior to the appearance of any local symptoms or signs (4). In 20-30% of patients with recently diagnosed RCC, radiological evidence of metastases exists at the time of presentation, and 20-40% of patients undergoing a nephrectomy to treat clinically localized RCC will develop metastases (4). The most common locations prone to metastases are the lungs and bones, followed in frequency by the regional lymph nodes, liver, adrenal gland, brain, gall bladder, pancreas and breasts (5,6). Additionally, several studies have reported a number of rare metastatic sites, including the ureteric stump, the ipsilateral and contralateral ureter, and the prostatic fossa (7-9). However, simultaneous metastases of RCC to the urinary bladder and left retroperitoneal space have not yet been reported. To the best of our knowledge, the current study describes the first case of RCC presenting with simultaneous metastases to the urinary bladder and left retroperitoneal space, occurring a short period after a radical nephrectomy. Case reportA 70-year-old man was referred to West China Hospital (Chengdu, China) with chronic left flank pain that had been present for a period of 2 months on December 15, 2014. For the ...

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Metastatic renal cell carcinoma to the bladder 12 years after radical nephrectomy

Cited by 26 publications

References 8 publications

Renal cell carcionoma with synchronous metastases to the bladder and lung

Renal cell carcionoma with synchronous metastases to the bladder and lung

Recurrent renal cell cancer: 10 years or more after nephrectomy

Simultaneous metastases of clear cell renal cell carcinoma to the urinary bladder and left retroperitoneal space: A case report and review of the literature

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