Metastatic renal clear cell carcinoma mimicking a gallbladder polyp: Case report and literature review

Zouari, Skander; Othmen, Mouna Ben; Abdessayed, Nihed; Mama, N.; Jarrar, Mohamed Salah; Sriha, Badreddine; Mokni, Moncef; Jaidane, Mehdi; Hmida, Wissem

doi:10.1016/j.ijscr.2019.09.032

Cited by 7 publications

(11 citation statements)

References 15 publications

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“…In the review of the published cases, there are several notable aspects for clinicians to be aware of. In contrast to what we present here, most metastatic lesions to the gallbladder are metachronous [ 4 ]. Rarely they are identified symptomatically, but rather incidentally, on surveillance imaging, or frequently postmortem.…”

Section: Discussioncontrasting

confidence: 99%

“…The majority of these have been found in autopsies though still representing only 0.58% of cases with metastatic RCC [ 2 ]. We were able to identify 59 case reports presenting metastatic RCC to the gallbladder [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Identification and resection of solitary metastatic lesions in addition to the primary has a known survival benefit, and in particular, successful outcomes have been published following resection of gallbladder metastases when R0 resections are performed [ 4 , 8 , 9 ]. While rare, identification of a gallbladder lesion in a patient with a history of RCC should prompt consideration of renal metastasis and subsequent cholecystectomy.…”

Section: Discussionmentioning

confidence: 99%

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Synchronous Metastatic Clear Cell Renal Cell Carcinoma to the Gallbladder With Metachronous Contralateral Recurrence

Pierce¹,

Dahmen²,

Hernandez³

2021

Cureus

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Renal cell carcinoma (RCC) classically metastasizes to the lungs, bones, adrenals, lymph nodes, liver, and brain. RCC metastasis to the gallbladder is rare occurring in less than 1% of metastases. We present a case of a 60-year-old male who at initial diagnosis of his large left renal mass was incidentally found to have a gallbladder mass. He underwent simultaneous open radical nephrectomy and cholecystectomy with pathology confirming solitary metastatic clear cell RCC (ccRCC). The patient chose surveillance and was without evidence of disease for three years. At three years, imaging showed a 2 cm contralateral renal mass which was cryoablated percutaneously. This case demonstrates not only the importance of a thorough review of initial and surveillance imaging but also of maintaining a broad differential for other solid organ masses in the setting of a primary RCC of the kidney.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Synchronous Metastatic Clear Cell Renal Cell Carcinoma to the Gallbladder With Metachronous Contralateral Recurrence

Pierce¹,

Dahmen²,

Hernandez³

2021

Cureus

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“…Some neoplasms, including melanoma and carcinoma, can metastasize to the gallbladder and frequently form a polypoid lesion [41] covered by the normal gallbladder epithelium [42], which is occasionally observed in IgG4-CC. Many metastatic neoplasms take over the characteristics of original neoplasms and suggest similar vascularities on CT and other vascular imaging, which can be clues for a diagnosis [41].…”

Section: Metastatic Neoplasmmentioning

confidence: 99%

Clinical and Image Characteristics of IgG4-Related Sclerosing Cholecystitis

Kuwatani

Sakamoto

2021

Diagnostics

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Since autoimmune pancreatitis (AIP) was established as a new disease entity, sclerosing change with abundant immunoglobulin-4 (IgG4)-positive plasma cells, storiform fibrosis, and obliterative phlebitis are main pathological features in IgG4-related diseases. Regarding IgG4-related sclerosing cholecystitis (IgG4-CC), which is occasionally associated with AIP cases and is rarely isolated, there are no diagnostic criteria and insufficient perceptions of the image findings. Although there have been some reports on IgG4-CC, differentiation between IgG4-CC and gallbladder cancer is very difficult in some cases with a localized lesion. In this review, we especially focused on image findings of IgG4-CC and summarized its image features for diagnostic assistance. The ultrasonography and CT findings of IgG4-CC could be classified into diffuse and localized types. Based on these findings, the presence of wall thickening with an intact or smooth mucosal layer, followed by a homogenously thickened outer layer, would be a helpful morphological finding to distinguish IgG4-CC from gallbladder cancer.

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“…3,4 Also, after nephrectomy, approximately 25% to 50% of patients will develop metastasis metachronously. 1,4 Usual metastasis sites are lung, bone, and liver. 3,5 The gallbladder is an unusual site for renal cell carcinoma metastasis; only a few cases have been reported, and most of them (48%) are located at fundus as our patient.…”

mentioning

confidence: 99%