Metastatic serous endometrial carcinoma to the ureter

Abstract

Metastatic endometrial carcinoma involving the renal parenchyma has been reported. However, ureteral metastasis is exceedingly rare. Here we describe what we believe to be the first case report of metastatic endometrial serous carcinoma to the ureteral and renal pelvic urothelium. The patient is a 68 year old female diagnosed with endometrial serous carcinoma three years prior to presentation who was found to have metastatic disease within the right ureter and retroperitoneal lymph nodes. Following a complete response in the lymph nodes to chemotherapy, she was treated with robot-assisted right nephroureterectomy for residual, isolated PET-avid right ureteral metastasis.

An unusual uterine papillary serous carcinoma with post therapy disseminating metastasis presenting as primary renal malignancy: a case report

“…Renal metastasis from UPSC has not yet been characterized. Only a limited number of studies have postulated endometrial carcinoma metastasis to the kidney or ureter 2 , 5 . Upper urinary tract involvement in endometrial cancer is rare and most often manifests as renal parenchymal metastasis.…”

“…Cochrane et al . 5 described a case in which a synchronous renal parenchymal lesion with no ureteral involvement was found simultaneously with primary serous endometrial carcinoma. In addition, a case of recurrent upper urinary tract endometrioid carcinoma, 11 years after hysterectomy for uterine cancer, was reported 2 , 5 .…”

“…Tumor metastasis is a sequential process comprising shedding, adhesion, infiltration, migration, and finally proliferation of primary tumor-derived and circulating malignant cells in competent organs leading to colonization 5 . Renal metastases from gynecological malignancies are uncommon, with only a few reported cases 2 , 5 . UPSCs usually metastasize to the pericardium, abdominal wall, skin, brain, lung, adrenal glands 1 – 3 , 5 , 6 , and pelvic lymph nodes.…”

“…Renal metastases from gynecological malignancies are uncommon, with only a few reported cases 2 , 5 . UPSCs usually metastasize to the pericardium, abdominal wall, skin, brain, lung, adrenal glands 1 – 3 , 5 , 6 , and pelvic lymph nodes. Metastases to the synchronous right renal and para-aortic lymph nodes 2 , as well as to the ureter 5 are rare.…”

“…UPSCs usually metastasize to the pericardium, abdominal wall, skin, brain, lung, adrenal glands 1 – 3 , 5 , 6 , and pelvic lymph nodes. Metastases to the synchronous right renal and para-aortic lymph nodes 2 , as well as to the ureter 5 are rare. Here, we report the case of a 75-year-old unmarried woman with UPSC and highlight the future studies investigating the incidence, histopathology, and outcomes of patients with advanced UPSC renal metastases may help optimize the treatment of these patients.…”