Metastatic spinal cord compression: diagnosis and management

Al-Qurainy, Rasha; Collis, Emily

doi:10.1136/bmj.i2539

Cited by 61 publications

(62 citation statements)

References 24 publications

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“…Its mutagenicity is connected with the production of organic metabolite (L-azidoadenine) that enters the nucleus and interacts with DNA. [13,33] Tested compounds could exert their antimutagenic effects through various mechanisms, including antioxidant potency, inhibition of mutagen activation, or direct chemical interaction with a mutagen. Within the frame of this study, radical scavenging potential of test compounds was evaluated.…”

Section: Discussionmentioning

confidence: 99%

In vitro mutagenic, antimutagenic, and antioxidant activities evaluation and biotransformation of some bioactive 4‐substituted 1‐(2‐methoxyphenyl)piperazine derivatives

Słoczyńska

Pańczyk

Waszkielewicz

et al. 2016

J Biochem & Molecular Tox

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In vitro mutagenic, antimutagenic, and antioxidant potency evaluation and biotransformation of six novel 4-substituted 1-(2-methoxyphenyl)piperazine derivatives demonstrating antidepressant-like activity were investigated. Mutagenic and antimutagenic properties were assessed using the Ames test; free radical scavenging activity was evaluated with 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay and biotransformation was performed with liver microsomes. It was found that all tested compounds are not mutagenic in bacterial strains TA100 and TA1535 and exhibit antimutagenic effects in the Ames test. Noteworthy, compounds possessing propyl linker between phenoxyl and N-(2-methoxyphenyl)piperazine displayed more pronounced antimutagenic properties than derivatives with ethoxyethyl linker. Additionally, compounds 2 and 6 in vitro biotransformation showed that primarily their hydroxylated or O-dealkylated metabolites are formed. Some of the compounds exhibited intrinsic clearance values lower than those reported previously for antidepressant imipramine. To sum up, the results of the present study might represent a valuable step in designing and planning future studies with piperazine derivatives.

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Section: Discussionmentioning

confidence: 99%

In vitro mutagenic, antimutagenic, and antioxidant activities evaluation and biotransformation of some bioactive 4‐substituted 1‐(2‐methoxyphenyl)piperazine derivatives

Słoczyńska

Pańczyk

Waszkielewicz

et al. 2016

J Biochem & Molecular Tox

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“…In mechanical pain, it recommended to stabilize the spine as conventional or minimally invasive arthrodesis, vertebroplasty, kyphoplasty, stereotactic radiosurgery or surgery traditional as vertebrectom. 7,29,[72][73][74][75][76][77][78][79][80][81][82][83][84] • Fracture: Sometimes fractures are the first symptom associated with pain. The thoracolumbar region is the most frequent site of spinal fractures.…”

Section: B Bmentioning

confidence: 99%

Spinal Metastasis: Diagnosis, Treatment and Prognosis - Integrative Review From 2012 to 2017

Cortez

2020

Coluna/Columna

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Care of the patient with spinal metastasis is challenging. The topic of this article is the treatment and prognosis of spinal metastases, aiming to enumerate and analyze literature that addresses this treatment and prognosis. The methodology used was an integrative review in the Virtual Health Library. Nineteen articles were identified demonstrating that there is research and scientific production in this area. The thematic units and their categories are: treatment decision - prognostic scales or clinical neurological evaluation; types of treatment - minimally invasive and/or traditional; and effectiveness of prognostic scales higher or lower probability of success, which provide insight into the different possibilities of patient evaluation and their applicability in practice. When making the diagnosis, planning the treatment, and establishing a prognosis, the professional must be in sync with current precepts and act based on the objective and subjective characteristics of the patients, such as beliefs and values, which although immeasurable, influence the survival and the effectiveness of treatment. Level of evidence I; Integrative Review.

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“…Differential diagnoses for all myelopathies include spondylosis (degenerative changes in the spine), epidural compression from abscess or haematoma, malignant compression, compression due to neurofibroma, pathological fracture, traumatic injury, subacute combined degeneration caused by severe B12 deficiency, and transverse myelitis 24567…”

Section: Answersmentioning

confidence: 99%

“…These lesions could be due to spondylitic myelopathy or due to the differential diagnoses of CSM. Differential diagnoses of CSM include: epidural abscess or haematoma, malignancy, metastases, neurofibroma, spondylosis, pathological/traumatic fracture, and transverse myelitis 2457…”

Section: Answersmentioning

confidence: 99%