Metastatic Spread of Osteosarcoma

Abstract

Summary.-A study is presented of the rate of metastatic spread of osteosarcoma. The series consists of 123 tumours in long bones and 26 elsewhere in the skeleton. All tumours occurred in otherwise normal bones and were histologically proven. With a few stated exceptions all the cases were consecutively registered.Both the mean disease-free interval from the time of starting treatment and the crude survival curves are given. The long bone cases are analysed by groups according to the method of treatment, the patient's sex, age and tumour site. There were too few tumours of all other sites to warrant this discriminative treatment. Whilst the results of surgical treatment are better than for radiotherapy or a combined technique, the differences are not statistically significant and the information is recorded primarily to assist the evaluation of new forms of treatment of occult and overt metastases. Some problems in connection with such clinical trials are discussed briefly.

Chondroblastic Osteosarcoma in A 13 Year Old Child

“…F) Less metastatic spread (6-51%) in jaws and metastasis in long bones(78-90%). 11 Nearly 70% of OS display a multitude of cytogenetic abnormalities including haploidy in chromosomes 1p11-p13,1q11-q12,1q21-q22,11p14-p15,14p11-p13,15p11-p13,17p, and 19q13; gain of chromosome 1; loss of chromosome 9,10,13 and 17; and amplification of chromosomes 6p12-p21,17p11 and 12q13-q14. 12 Variants of OS recognized by WHO differ in location,clinical behavior and degree of cellular atypia in that majority are intramadullary (conventional) OS and remaining are surface OS which are further subdivided into paraosteal, periosteal and high grade surface OS.…”

Osteogenic sarcoma. Immunologic parameters before and during immunotherapy with tumor-specific transfer factor.

“…In more than 50% of patients, metastastic lesions become clinically evident within 6 mo of diagnosis. The survival of patients with metastases is counted in weeks (19), and the incidence of spontaneous remissions is less than 1% (20). For these reasons, this tumor was chosen as the first to be treated with tumorspecific transfer factor.…”

“…Osteogenic sarcoma cell lines TE-85 (passages [17][18][19], and TE-418 (passages [10][11][12], and TE 415, the matching fibroblast line to TE 418, were provided by Dr. R. McAllister. Control cell lines included those from mammary carcinoma, hypernephroma, rhabdomyosarcoma, and matching fibroblast cell lines (12).…”

The Surgical Treatment and Outcome of Pathological Fractures in Localised Osteosarcoma

“…Osteosarcoma is the most common primary malignant tumour of bone in children and young adults (Glass and Fraumeni 1970), with between 130 and 150 new cases seen in the UK every year (Price and Jeffree 1973). In highgrade primary malignant bone tumours, fractures occur either spontaneously or after minimal trauma because of the high cellularity, poor differentiation and loss of matrix (Enneking 1983).…”