Metastatic squamous cell carcinoma of penis in an HIV-infected man presenting with cutaneous manifestations

Penile squamous cell carcinoma (pSCC) is a rare cancer with several known risk factors. High-risk HPVs are considered to be responsible for about 50% of cases 1 and it is established that concomitant HIV infection accelerates disease progression. 2 Although significant advancements have been made in systemic tumor therapy, the prognosis of advanced pSCC remains inauspicious with poor quality of life.We report an extraordinary response of an HIV positive patient with advanced penile SCC, treated with cemiplimab.F I G U R E 1 A, Clinical evaluation at different time points showing, from left to the right, painful ulcerated, and sclerotic lesion with serumpurulent secretion involving penis and scrotum, with purple infiltrated plaques on the pubis and enlarged lymph nodes. Second images shows partial regression after 1 month of treatment and third reveal total remission after 3 months. B, Contrast-enhanced computed tomography (ce-CT) acquired pre-therapy (B, middle row) showed inhomogeneous enhancement in penis (white arrow) and in pathological lymph nodes in the inguinal, iliac, and paracaval region (red circles). C, After epicystostomy and 12 weeks of treatment with cemiplimab, a further ce-CT scan demonstrated no pathological enhancement in penis (white arrow) and regression of the pathological lymph nodes (red circles)

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Metastatic penile squamous cell carcinoma successfully treated with cemiplimab in an HIV patient

Proietti

Skroza

Filippi

et al. 2021

Dermatologic Therapy

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The association between penile cancer and HIV infection: A literature review

et al. 2023

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Penile cancer is a rare malignancy which HIV infection appears to increase the risk of. The magnitude of this risk and the pathogenesis remain unclear. A comprehensive review of the literature was undertaken using conventional search strategies. Twenty-four publications were identified by this methodology, of which nine were case reports and 15 were observational studies. These studies were highly heterogeneous, with varying study designs, populations, and objectives. The risk of penile cancer within HIV-positive individuals is significantly greater than in those without HIV (RR = 3 .7 to 5.8, 3 studies; SIR = 3.8 to 11.1, 4 studies). HIV is also shown to influence disease characteristics, with a four-fold increased risk of death from penile cancer. Moreover, progression from intraepithelial neoplasia occurs earlier in HIV, six years sooner than in HIV-negative men. HIV-positive men have a higher prevalence of HPV infection. Ethnicity is also shown to modulate the relationship between HIV and penile carcinoma, with a higher risk of cancer in Hispanic, compared with Caucasian, HIV-positive men. This review has collated data from diverse sources to improve understanding of the relationship between HIV and penile cancer. This relationship has been quantitatively and qualitatively characterised and highlights areas deserving further enquiry.

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Metastatic squamous cell carcinoma of penis in an HIV-infected man presenting with cutaneous manifestations

Cited by 2 publications

References 10 publications

Metastatic penile squamous cell carcinoma successfully treated with cemiplimab in an HIV patient

Metastatic penile squamous cell carcinoma successfully treated with cemiplimab in an HIV patient

The association between penile cancer and HIV infection: A literature review

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