Metastatic Squamous Spindle Cell Carcinoma of the conjunctiva

Alkatan, Hind M.; Al-Motlak, Mohammed A.; Alshedoukhy, Ahlam

doi:10.1016/j.sjopt.2010.06.004

Cited by 9 publications

(6 citation statements)

References 10 publications

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“…The sarcomatous component is vimentin-positive with weak staining for cytokeratin/EMA. p63 and p40 are both useful markers with comparable sensitivity for epithelial differentiation in such cases, however p40 has greater specificity [12] . Histological feature to guide Immunohistochemistry (IHC) for sarcomatoid squamous cell carcinoma is the presence of spindle cell tumour, which may have continuity with surface epithelium.…”

Section: Discussionmentioning

confidence: 99%

Sarcomatoid Squamous Cell Carcinoma of the Conjunctiva: A Rare Entity and A Brief Review of Literature

Agrawal¹,

Modaboyina²,

Sen³

et al. 2021

Ann of Pathol and Lab Med

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Sacrcomatoid variant of squamous cell carcinoma has been known to involve numerous tissues like an aerodigestive tract, skin. A reddish mass of the left bulbar conjunctiva, with intraocular extension on ultra-bio-microscopy (UBM) was present. Histopathologic examination showed the characteristic spindle-shaped cells in continuity with the overlying epithelium with positive immunostains for cytokeratin, epithelial membrane antigen and vimentin. The presence of such an entity in the conjunctiva is rare and here we report such a case, this being the 37th case to be documented in literature. We also give a brief review of literature.

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Section: Discussionmentioning

confidence: 99%

Sarcomatoid Squamous Cell Carcinoma of the Conjunctiva: A Rare Entity and A Brief Review of Literature

Agrawal¹,

Modaboyina²,

Sen³

et al. 2021

Ann of Pathol and Lab Med

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“…Mortality from metastatic lung disease had been reported by Seregard and Kock and Alkatan et al . [ 5 11 ] In the present case of a rare, presumably more aggressive SSCC accompanied with both intraocular and intraorbital invasion, MMC was used as an adjuvant therapy with lesion soaking after tumor excision during surgery and topical eye drops was administered at clinical follow-up. Topical MMC has been documented effective without significant adverse effects.…”

Section: Discussionmentioning

confidence: 99%

The clinical presentation and treatment of an invasive conjunctival squamous spindle cell carcinoma

Wang

Chen

Wang

et al. 2022

Taiwan Journal of Ophthalmology

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Ocular surface squamous neoplasia represents neoplastic epithelial abnormalities of conjunctiva and cornea, ranging from squamous dysplasia to invasive squamous cell carcinoma and is both sight- and life-threatening. Squamous spindle cell carcinoma (SSCC) of conjunctiva is a rare variant with distinct behavior which is thought to be more locally aggressive. We describe an 83-year-old woman with a progressively enlarging huge SSCC in her right eye over the past 2 years. The tumor bulged out with local invasion into intraocular and orbital cavities. Wide excision of the tumor with frozen section control was performed. After surgery, topical 0.03% mitomycin C was given as adjuvant therapy. At 40-month follow-up, the lesion site showed no evidence of local recurrence. This case provides a valuable and complete experience of the clinical presentation for the progression and treatment of this rare disease.

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“…In other large OSSN case series of 389 patients (57 SCC) [29] and 288 patients (62 SCC) [7], no intraocular invasion was reported. Variants of conjunctival SCC manifest more aggressively and have an increased likelihood of exhibiting intraocular invasion, namely the mucoepidermoid [16,30,31] and spindle cell variants [32,33,34] as well as patients displaying HIV positivity [35]. Rao and Font [30] reviewed 5 cases of mucoepidermoid carcinoma of the conjunctiva and found intraocular invasion in 2 cases and orbital extension in 3 cases.…”

Section: Discussionmentioning

confidence: 99%

Conjunctival Squamous Cell Carcinoma with Corneal Stromal Invasion in Presumed Pterygia: A Case Series

Mendoza¹,

Craven

et al. 2018

Ocul Oncol Pathol

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Aim: To describe 4 cases of conjunctival squamous cell carcinoma (SCC) with corneal stromal invasion. Methods: Retrospective, clinicopathologic case series. Results: All patients had prior resections of presumed pterygia. The degree of corneal involvement dictated the extent of surgical management. One eye with localized invasion was treated with lamellar keratoplasty and plaque brachytherapy. Another case with widespread invasion warranted penetrating keratoplasty and eventual enucleation. Two cases were treated medically prior to surgical intervention: one with localized invasion was treated with topical interferon and retinoic acid; another with significant inflammation was treated with doxycycline and fluorometholone. The patient who underwent keratoplasty and brachytherapy had no recurrence after 7 years of follow-up. Those initially treated medically had resections of recurrence but ultimately required enucleation. Histologically, specimens demonstrated SCC invading the deep corneal stroma, with 2 tumors of the mucoepidermoid type. Conclusions: This series demonstrates the importance of maintaining clinical suspicion of conjunctival squamous neoplasia in pterygia. We recommend that all excised pterygia be submitted for histopathologic evaluation and be carefully evaluated for dysplasia and variants of SCC associated with increased risk of intraocular invasion. Undetected ocular surface squamous neoplasia may give rise to potentially vision- and eye-threatening invasive corneal SCC.

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Metastatic Squamous Spindle Cell Carcinoma of the conjunctiva

Cited by 9 publications

References 10 publications

Sarcomatoid Squamous Cell Carcinoma of the Conjunctiva: A Rare Entity and A Brief Review of Literature

Sarcomatoid Squamous Cell Carcinoma of the Conjunctiva: A Rare Entity and A Brief Review of Literature

The clinical presentation and treatment of an invasive conjunctival squamous spindle cell carcinoma

Conjunctival Squamous Cell Carcinoma with Corneal Stromal Invasion in Presumed Pterygia: A Case Series

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