Metastatic syringoid eccrine carcinoma of the nipple

Ballardini, Pierluigi; Margutti, Guido; Pedriali, Massimo; Querzoli, Patrizia

doi:10.2147/imcrj.s32217

Cited by 9 publications

(12 citation statements)

References 24 publications

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“…Tumor cells can organize into nests, cords, or tubules, some of which exhibit a morphology resembling tadpole-like syringoma due to the cords of epithelial tissue. Cytonuclear atypia is not very evident, as is the presence of mitotic activity, which may even be absent [1,11,14,16]. The epithelial component of the tumor may show a cribriform pattern in focus (Figure 3), which makes it difficult to distinguish from other tumors [3].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, in addition to the immunohistochemical pattern disagreeing with the morphological pattern, there is no accumulation of mucin, as occurs in ADC, favoring the diagnosis of SEC [3,14,19,17]. Imaging studies have been reported to be important but for delimiting the lesion, but not for diagnosis of SEC [11], or searching for metastases [9,10,15].…”

Section: Discussionmentioning

confidence: 99%

“…In this case, the criterion standard treatment was used, so surgical resection of the lesion was performed. This method is considered to be optimal and the main treatment choice, since the other option, radiation, is rarely used since the tumor is considered resistant, but it has been reported in the literature as adjuvant therapy [11].…”

Section: Discussionmentioning

confidence: 99%

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Syringoid Eccrine Carcinoma in the Abdominal Wall: A Rare Case Report and Literature Review

2019

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Patient: Male, 58-year-oldFinal Diagnosis: Syriongoid eccrine carcinomaSymptoms: Burning sensationMedication: —Clinical Procedure: Surgical excisionSpecialty: SurgeryObjective:Rare diseaseBackground:Syringoid eccrine carcinoma (SEC) is an extremely rare malignant adnexal neoplasm derived from eccrine sweat glands, of unknown pathogenesis. We report a case of this rare entity presenting in the abdomen, which is the only one reported in this area and the only case of SEC in a patient with so many comorbidities.Case Report:A 58-year-old black male from Brazil reported a nodular lesion in the abdomen with a progressive increase in size and pain and local burning sensation. The histopathological examination showed a syringoid eccrine carcinoma.Conclusions:We present a rare case of SEC and did an extensive literature review in order to describe the clinical characteristics, histopathological findings, immunohistochemical profile, treatments, and difficulties found in the diagnosis of this tumor. To avoid misdiagnosis, we gave special attention to biopsy quality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Syringoid Eccrine Carcinoma in the Abdominal Wall: A Rare Case Report and Literature Review

2019

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“…3,7,8 The tumor is primarily composed of thin strands and nests of cuboidal epithelium with variable degrees of glandular differentiation. 2 Intracytoplasmic lumina are sometimes evident.…”

Section: Discussionmentioning

confidence: 99%

Ductal eccrine carcinoma of the axilla: a diagnostic pitfall

Brito

Dionísio

Ferreira

et al. 2017

An. Bras. Dermatol.

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Ductal eccrine carcinoma (DEC) is a rare sweat gland carcinoma with ductular differentiation. Clinically, it is characterized by a slowly growing, hardened plaque or nodule predominantly located on the head and neck. Histologically, DEC shares similar features to invasive breast carcinoma, thus causing great diagnostic challenges. We report a 69-year-old woman who presented with a hardened plaque on the axilla. A skin biopsy was performed and metastatic invasive breast carcinoma could not be ruled out. Complete excision and further workup were subsequently conducted, leading to the diagnosis of estrogen receptor positive DEC with associated axillary lymph node metastases. The patient received adjuvant radiotherapy to the left axilla and was started on oral letrozole. She is disease-free 14 months after initial diagnosis.

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“…Histologically, SEC have a variety of histological feature and show dilated tubules within dense fibrocollagenous matrix, sometimes with a tadpole appearance, small neoplastic ducts, solid islands, cellular cords, and keratinizing and nonkeratinizing cysts 14 . Cells show mild to marked nuclear atypia, usually of moderate atypia and a variable number of mitoses.…”

Section: Discussionmentioning

confidence: 99%

Syringoid Eccrine Carcinoma of the Thigh

et al. 2017

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Syringoid eccrine carcinoma (SEC) is a rare cutaneous malignant tumor thought to be derived from eccrine sweat apparatus. It is usually present in the head, neck and trunk region, and often occurs in the fourth to seventh decades of life. A 94-year-old male patient visited our department with an 80-year history of a lesion showing a 2×2 cm sized well-demarcated round shaped erythematous to pinkish colored nodule with ulcer on his left thigh. Histological findings revealed a tumor consisted mainly of numerous small cords and nests forming luminal or tubular structures and tumor cells showing variable atypia. Some ductal structures showed tadpole appearance. On immunohistochemical staining, epithelial membrane antigen, S-100, cytokeratin 7 and carcinoembryonic antigen were reactive and Ki-67 showed less than 10% positivity. Based on these findings, the final diagnosis was made as SEC. The patient was treated with local wide excision and didn't show any recurrence during the follow-up period of 12 months. Herein, we report a very rare case of SEC which occurred on the left thigh and discuss 10 cases of SEC presented on the extremities, including our case.

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Metastatic syringoid eccrine carcinoma of the nipple

Cited by 9 publications

References 24 publications

Syringoid Eccrine Carcinoma in the Abdominal Wall: A Rare Case Report and Literature Review

Syringoid Eccrine Carcinoma in the Abdominal Wall: A Rare Case Report and Literature Review

Ductal eccrine carcinoma of the axilla: a diagnostic pitfall

Syringoid Eccrine Carcinoma of the Thigh

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