Metastatic tumors in oral mucosa and jawbones: Unusual primary origins and unusual oral locations

Kaplan, Ilana; Raiser, V.; Shuster, Amir; Shlomi, Benjamin; Rosenfeld, Eli; Greenberg, Adi; Hirshberg, Avraham; Yahalom, Ran; Shnaiderman-Shapiro, Anna; Vered, Marilena

doi:10.1016/j.acthis.2019.151448

Cited by 28 publications

(31 citation statements)

References 20 publications

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“…Lungs are the most common site of metastasis. Other sites of metastasis include the liver, brain, kidneys, heart, and skin [1][2][3][4]. The findings of some small studies have indicated the role of oral drugs like pazopanib, dasatinib, and the IDH1 inhibitor ivosidenib [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…In patients presenting with oral cavity metastasis, the primary malignancies commonly involve the breasts, lung, thyroid, kidney, skin, and gastrointestinal tract. Lung and breast cancers are the most common primary malignancies in affected males and females, respectively [1][2][3][4].…”

Section: Discussionmentioning

confidence: 99%

“…Metastases to the oral cavity are rare and usually occur from melanomas and cancers of the breast, lung, kidney, and liver [1][2][3][4]. To the best of our knowledge, only six cases of chondrosarcoma with metastases to the oral cavity, maxilla, and/or mandible have been reported in the literature, with the last case having been reported three decades earlier in 1991 [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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A Rare Case of Chondrosarcoma With Metastasis to the Oral Cavity

Upadhyay¹,

Prakash²,

Rana³

et al. 2021

Cureus

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Chondrosarcomas with metastases to oral cavities are extremely rare. To the best of our knowledge, only six cases of chondrosarcoma with metastases to the oral cavity, maxilla, and/or mandible have been reported in the English-language literature. The last such case was reported three decades earlier; none of the reported cases were from India. We present the case of an Indian patient with chondrosarcoma in the knee region, who was treated with surgical excision in 2013. However, he experienced a recurrence in 2019, developed upper gingival metastasis in 2020, and succumbed within two months of this unique presentation. Oral metastatic lesions have a wide differential diagnosis, and awareness of this rare presentation can help clinicians maintain an index of suspicion for an underlying metastatic malignancy. Our experience emphasizes the importance of detailed history-taking, clinical examination, and consideration of metastases as a differential diagnosis, even if there is no reported history of malignancy. Such lesions may also be the first sign of an occult primary tumor, which will require prompt investigation for early diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Rare Case of Chondrosarcoma With Metastasis to the Oral Cavity

Upadhyay¹,

Prakash²,

Rana³

et al. 2021

Cureus

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“…Specifically, of the maxillary bones, the mandible is the most frequently affected location. In soft tissues, the attached gingiva is the most common location for the settlement of metastases, followed by the tongue ( 4 , 5 ). It is believed that the dissemination mechanism of a neoplasm from the primary location to the oral cavity is basically through blood dissemination, through the epidural venous plexus (Batson venous system), which vascularizes the axial skeleton and the head region and neck ( 6 - 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…This type of metastases is a sign of widespread primary cancer and is a sign of poor prognosis, with 5-year survival rate below 5% ( 3 , 4 , 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

Incidence rate of metastases in the oral cavity: a review of all metastatic lesions in the oral cavity

Oliver-Puigdomènech¹,

González-Navarro²,

Polis-Yanes³

et al. 2021

Med Oral

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Background Metastases in the oral cavity are rare and account for only 1 to 3% of all malignant lesions in this area. The primary location from which most metastases have been described in the oral cavity in adult patients include lungs, breasts, kidneys and colon. Material and Methods A systematic search of the literature was carried out following the PRISMA statement in PubMed database. Clinical trials and case series published in the last 10 years [2010-2020] were eligible to be selected. The headings and keywords used in the searches were “cancer” AND “oral metastases”, “incidence” AND “oral metastases”, “oral metastases” AND “jaw bone”, “oral metastases” AND “soft tissue”. Results For the study of the incidence of metastases in the oral cavity, 9 reports of clinical trials and 7 retrospective studies of case series have been included in this article. The primary locations from which more metastases have been described in the oral cavity are lungs (30.6% or 183 cases), breasts (22.2% or 133 cases), liver (15.5% or 93 cases), prostate (9 % or 54 cases), thyroid glands (8.1% or 49 cases), kidneys (7.3% or 44 cases), skin (2.3% or 14 cases), soft tissues (2% or 12 cases), colon (2% or 12 cases) and gastrointestinal (0.6% or 4 cases). These metastases have a predilection for hard tissues. The clinical presentation of these lesions varies from painless granulomatous lesions to lytic areas in the jaws. Conclusions Although metastases in the oral cavity is an uncommon pathology, early diagnosis is needed so that in the event that it is the first manifestation, it allows the primary tumor to be diagnosed as soon as possible. Key words: Cancer, oral metastases, incidence, jaw bone, soft tissue.

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Tumor Metastasis to the Oral Soft Tissues and Jaw Bones: A Retrospective Study and Review of the Literature

Pakfetrat,

Dalirsani,

Saghravanian

et al. 2024

Clinical & Exp Dental Res

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ObjectivesMetastasis to the oral soft tissues and jaw is rare and accounts for 1%–3% of maxillofacial malignancies. These lesions usually occur in the context of an extensive malignant tumor with a poor prognosis.Materials and MethodsArchived cases from the Oral and Maxillofacial Pathology Department of the Faculty of Dentistry and two hospital centers of Mashhad University of Medical Sciences were examined. Inclusion criteria were cases with available records of pathologically confirmed metastatic lesions of the oral cavity with or without diagnosed primary malignancy.ResultsMetastatic lesions in the oral cavity and jaw were found in 18 patients, including seven women and 11 men, with a mean age of 49.5 years. Metastatic lesions were more common in the jaw (66%) and particularly in the mandible (38%) than elsewhere. In the case of soft tissue metastases, the gingiva was more affected than other sites. The primary tumor was most commonly in the kidney in men and in the breast in women (36%–28%). In addition, the diagnosis of a metastatic lesion led to the detection of the primary tumor elsewhere in six out of 18 cases (33.3%).ConclusionsEarly diagnosis of the lesions is challenging, given the absence of specific signs or symptoms, which, in some cases, nonetheless resemble inflammatory, benign, reactive lesions. Therefore, dentists play a crucial role in diagnosing such lesions, as they lead to the discovery of hidden distant primary tumors. Biopsy should always be considered for suspicious lesions, even if the probability is very low.

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Metastatic tumors in oral mucosa and jawbones: Unusual primary origins and unusual oral locations

Cited by 28 publications

References 20 publications

A Rare Case of Chondrosarcoma With Metastasis to the Oral Cavity

A Rare Case of Chondrosarcoma With Metastasis to the Oral Cavity

Incidence rate of metastases in the oral cavity: a review of all metastatic lesions in the oral cavity

Tumor Metastasis to the Oral Soft Tissues and Jaw Bones: A Retrospective Study and Review of the Literature

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