Metastatic tumors of the orbit and ocular adnexa

Abstract

Breast carcinoma continues to account for the majority of metastatic lesions of the orbit and ocular adnexa. Although the overall prognosis for patients with such lesions remains poor, the longer survival time for patients with breast carcinoma, the availability of novel targeted treatment options and new investigational agents, and advances in radiotherapy techniques may lead to better quality of life and preservation of ocular function for patients with metastatic orbital tumors.

Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature

“…1,6 The prognosis is poor with a median survival of 6 to 9 months. 5 The most commonly reported primary sites are breast (28%-59%), lung (8%-12%) and prostate (3%-10%).…”

“…5 The most commonly reported primary sites are breast (28%-59%), lung (8%-12%) and prostate (3%-10%). 1,7 Of the 48 published cases of orbital and ocular metastases secondary to prostate cancer since 1975, 38% were initial presentations. 7,[8][9][10][11][12][13][14][15][16][17][18][19] RCC is a rare cause of intraocular and orbital metastases, accounting for 3% of metastatic orbital tumours.…”

“…These symptoms may progress over weeks to months. 1,30 Examination may reveal proptosis, ptosis, ophthalmoplegia or red eye. Complications include retinal detachment, uveitis, papilledema and secondary glaucoma.…”

“…29 Prostate cancer cells most frequently metastasize to the orbital bone, while RCC shows a predilection for orbital soft tissue. 1,20 Clinical presentation and diagnosis…”

“…In 25% of these, it is the presenting sign of malignancy. [1][2][3][4] Frequently, this presents a diagnostic challenge and represents a poor prognosis. 5 We present an unusual case of proptosis as the index sign of malignancy and review the literature surrounding orbital and ocular metastases in prostate cancer and renal cell carcinoma (RCC).…”