Metastatic uveal schwannoma of blue‐eyed dogs

Abstract

A formalin-fixed left, blue eye, from a 9-year-old, spayed female beagle dog was submitted to the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) for light microscopic evaluation. The history included glaucoma and an abnormal appearance for 6 months and then the development of a uveal mass. The histologic diagnosis was a spindle cell tumor of blue-eyed dogs (SCTBED). In June of 2012, the dog was euthanized due to ailing health, and there was radiographic and postmortem examination evidence of neoplastic metastasis. This is the first reported case of this primary ocular neoplasm metastasizing, and we propose to rename SCTBED as a uveal schwannoma of blue-eyed dogs.

Orbital rhabdomyosarcoma and traumatic neuroma following enucleation for a uveal schwannoma in a dog: a case report

“…This sequence of presentation of these neoplasms provokes an interesting discussion to potential biologic behavior and pathogenesis of the uveal schwannoma, although the etiology of uveal schwannoma is still unclear. The behavior of this tumor is unclear at this time; however, they have been infrequently reported to be metastatic . In this case, scleral invasion of the uveal schwannoma was not found on initial histopathology OD, consistent with pathological findings of Duke et al reporting that only 6/52 cases of uveal schwannoma in the COPLOW collection having scleral invasion .…”

“…Uveal schwannomas, previously known as spindle cell tumor of blue‐eyed dogs (SCTBED), were first described by Zarfoss et al in 2007 . These tumors develop in the anterior uvea of dogs with blue iridal tissue; however, limited literature is available with one case report of uveal schwannoma exists occurring in the anterior uvea in a cat . Uveal schwannomas are comprised of two cell patterns: spindle cells with nuclei arranged in stacked alignments, or palisades (an Antoni‐A pattern) and spindle cells arranged in interlacing bundles and sheets (an Antoni‐B pattern) that are vimentin and S100 positive, indicating mesenchymal and neural crest origins.…”

Frameless stereotactic volumetric modulated arc radiotherapy of brachial plexus tumours in dogs: 10 cases

“…6 Metastases are rare, although lung and uveal metastases have been reported. 5,7 Concerning several published articles regarding canine PNSTs, no recent work has been conducted specifically about the treatment of PNSTs. At present, surgery is considered the treatment of choice.…”

Malignant Uveal Schwannoma With Peripheral Nerve Extension in a 12-Week-Old Color-Dilute Labrador Retriever

“…Local invasion of the sclera is present in 11.5% of the COPLOW cases, and there is 1 case of distant metastasis to the lung, liver, and mesenteric lymph nodes, but none of the COPLOW cases have histologic evidence of peripheral nerve involvement or extension. 2 The presence of well-differentiated cartilage is a phenomenon not observed in uveal schwannoma of blue-eyed dogs. Divergent osteogenic, myxomatous, and myoblastic differentiation have been described in a malignant peripheral nerve sheath tumor in a Golden Retriever dog, and divergent differentiation of human conventional schwannomas-usually in the setting of NF2-rarely includes cartilage and/or bone formation.…”