Metastatischer Befall pelviner Lymphknoten in Abhängigkeit vom Grading und Staging beim Prostatakarzinom

Half-Life of Prostate-Specific Antigen after Radical Prostatectomy: The Decisive Predictor of Curative Treatment?

“…These have included various tumor-grading systems [1][2][3], the nu clear shape [4,5] tumor volume [6] and local extent [7,8] or number of positive lymph nodes [9,10]. A long-term study after radical prostatectomy shows a large propor tion of capsular invasion and even penetration in patients considered to have been cured after a follow-up of at least 15 years [11], After evaluation of the diagnostic value of prostatespecific antigen (PSA) [12], many investigations have tried to correlate absolute PSA values with tumor volume, lymph node involvement or response to therapy in var ious pre-and post-treatment phases.…”

Prostatic Cancer - What to Do?

“…An increase in volume of the tumor decreases the tumor cell differentiation and increases the metastatic activity of the tumor (table 4) [23,25,43,56]. Thus the probability of long-term disease-free or absolute survival is much reduced in patients with a high grade tumor as compared to the survival in patients with low grade or intermediate grade tumor [43,63].…”