Metastin Suppresses the Motility and Growth of CHO Cells Transfected with Its Receptor

Hori, Akira; Honda, Susumu; Asada, Megumi; Ohtaki, Tetsuya; Oda, Kazunori; Watanabe, Takuya; Shintani, Yasushi; Yamada, Takao; Suenaga, Masato; Kitada, Chieko; Onda, Haruo; Kurokawa, Tsutomu; Nishimura, Osamu; Fujino, Masahiko

doi:10.1006/bbrc.2001.5470

Cited by 95 publications

(57 citation statements)

References 23 publications

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“…This is in stark contrast with what was seen in CHO/GPR54 cells after exogenous exposure to kisspeptins. However, there was a significant decrease in soft agar colony formation as observed in CHO/GPR54 cells (33,34). The inability of KISS1 overexpression to inhibit motility of MDA-MB-435 cells may be due to suboptimal levels of kisspeptin secretion and/or inadequate levels of GPR54 at the cell surface.…”

Section: In Vitro Implications For Gpr54/kisspeptin and Metastasismentioning

confidence: 99%

The KISS1 metastasis suppressor: mechanistic insights and clinical utility

Kevin¹

2006

Front Biosci

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Melanoma is a highly metastatic cancer that accounts for the majority of skin cancer deaths. Unfortunately, very few improvements have been made during the last 20 years in the management of melanoma metastases, which is the major cause of melanoma deaths. Therefore, identification of molecular targets that can be exploited in the clinic to treat metastatic disease is desperately needed. The KISS1 metastasis suppressor gene has emerged as a promising molecular target for the management of metastatic disease. This review compiles data regarding the molecular and biochemical properties of KISS1 and its cognate receptor, focusing on the properties believed to be most pertinent to the use of KISS1 in the clinical setting. In addition, clinical data that supports KISS1 as having a dual role as a prognostic indicator and a therapeutic target for the management of metastatic disease will be highlighted.

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Section: In Vitro Implications For Gpr54/kisspeptin and Metastasismentioning

confidence: 99%

The KISS1 metastasis suppressor: mechanistic insights and clinical utility

Kevin¹

2006

Front Biosci

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“…4 More recently, it has been reported that kisspeptin or metastin, a product of the KiSS-1 gene, is thought to possess potent antimetastatic property and an orphan receptor for this protein has been detected. [7][8][9][10][11][12] Although the exact mechanism of the tumor suppressor activity of KiSS-1 is yet to be revealed, the KiSS-1 gene product has recently been shown to repress type IV collagenase (MMP-9) expression and a loss of KiSS-1 expression has been associated with loss of membrane E-cadherin expression. 4,10 Moreover, very recently it was shown that activation of a Gprotein-coupled receptor (also known as AXOR12, GPR54, or hOT7T175) by KiSS-1 peptide changed cell morphology and actin filament reorganization in NIH3T3 cells.…”

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confidence: 99%

Downregulation of KiSS‐1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma

Dhar

Naora

Kubota

et al. 2004

Intl Journal of Cancer

119

104

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KiSS-1 is a promising candidate tumor-suppressor gene and may play a key role in the metastatic cascade. The expression profile and the role of KiSS-1 in cancer progression are largely unknown in most of the cancers, including gastric cancer. In this study, KiSS-1 expression was evaluated by RNase protection assay and localization was done by in situ hybridization in 40 gastric cancers and their adjacent normal gastric mucosa. For comparison with clinicopathologic characteristics and patient prognosis, all patients were divided into 2 groups having high and low KiSS-1 expression by using the median as the cutoff value of KiSS-1 expression as determined by the RNase protection assay. Gastric cancers with low KiSS-1 had frequent venous invasion, distant metastasis and tumor recurrence. Accordingly, patients with low KiSS-1-expressing tumors had a significantly worse overall and disease-free survival. In multivariate analysis, KiSS-1 became the strongest independent prognostic factor among the conventional prognosticators for gastric cancer patients. Collectively, these findings suggest that KiSS-1 may play a crucial role in gastric cancer invasion and could be a useful target for therapeutic intervention.

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“…если ГнРГ-нейроны сами экспрессируют ER, очевидно, что регулирующее действие эстра-диола на ГнРГ-нейроны может быть трансси-наптическим потому, что эстрадиол регулиру-ет синаптическую передачу к этим клеткам [44] и нейроны, которые считаются афферентными к ГнРГ-нейронам, экспрессируют как ER-α, так и ER-β [45][46][47][48]. Особый интерес вызывают последние ис-следования, посвященные нейромодулятору кисспептину, о возможности действия эстра-диола по механизму обратной связи при регу-ляции ГнРГ-нейронов [9,49,50]. Известно, что 30 % пациентов с идиопатическим гипогона-дотропным гипогонадизмом (ИГГ) имеют му-тации в гене GPR54, приводящие к потере его функции [12].…”

Section: роль кисспептина и его рецептора в функционировании репродукunclassified

Role of Kisspeptine in Regulation of Reproductive Function

et al. 2016

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Research objective: to identify a role of kisspeptine in the regulation of reproduction function.Materials: literature data by foreign authors for the period from 1985 till 2016.Methods: systematic analysis and compilation of information in the literature.Results. The article provides a review of literature data on research of kisspeptine gene and its receptor; it includes description of their role in regulation of reproduction function and mutation in the genes responsible for realization of kisspeptine and neurokinin signaling pathways. Features of kisspeptine secretion in patients with hypogonadotropic hypogonadism, premature sexual development, hyperprolactinemic deficiency of ovaries, polycystic ovarian syndrome, genital endometriosis and opportunity of kisspeptine use in clinical practice as an ovulation trigger are described.Conclusion. It is necessary to carry out further studies for clarification of kisspeptine role in patients with various diseases and the opportunity of its use as a therapeutic target.

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Metastin Suppresses the Motility and Growth of CHO Cells Transfected with Its Receptor

Cited by 95 publications

References 23 publications

The KISS1 metastasis suppressor: mechanistic insights and clinical utility

The KISS1 metastasis suppressor: mechanistic insights and clinical utility

Downregulation of KiSS‐1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma

Role of Kisspeptine in Regulation of Reproductive Function

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