An efficient fiber-to-chip interface via an intermediated CdS nanowire is demonstrated. The fiber mode is firstly squeezed through a fiber taper drawn at the end of a single-mode fiber, then evanescently coupled into an intermediated CdS nanowire with a longitudinally tapering profile, and finally coupled into an on-chip silicon waveguide (SiW) via a waveguide taper fabricated on it. Since the fiber-nanowire-SiW cascade structure is designed to match effective indices in each coupling area, such a fiber-to-chip interface ensures a bidirectional coupling efficiency up to 90% and a 3-dB bandwidth over 100 nm in experiments. The difference of coupling efficiencies between the TM or TE modes is less than 0.5 dB in the spectral range of 1545-1635 nm. The footprint of the on-chip coupling structure is about 10 µm in size. The results may provide a compact, efficient, and versatile fiber-to-chip interface in applications including optical interconnects, coherent communication, and quantum optical circuitry.