2019
DOI: 10.1002/anie.201901443
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Metasurface‐Based Molecular Biosensing Aided by Artificial Intelligence

Abstract: Molecular spectroscopy provides unique information on the internal structure of biological materials by detecting the characteristic vibrational signatures of their constituent chemical bonds at infrared frequencies. Nanophotonic antennas and metasurfaces have driven this concept towards few‐molecule sensitivity by confining incident light into intense hot spots of the electromagnetic fields, providing strongly enhanced light‐matter interaction. In this Minireview, recently developed molecular biosensing appro… Show more

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Cited by 107 publications
(92 citation statements)
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References 92 publications
(158 reference statements)
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“…Metasurfaces have emerged as one of the most exciting research directions in optics, where light scattering properties of materials can be controlled at will by designing subwavelength structures (“meta‐units”) that strongly interact with the incident light. [ 1–8 ] While originally only enabling static functionality, [ 9 ] these concepts have recently been extended towards active optical devices by employing tunable metasurfaces for sensing and light focusing applications, where the optical response can be controlled using light inclination, [ 10–12 ] stretchable substrates, [ 13 ] electrostatic biasing of two‐dimensional (2D) materials such as graphene, [ 14,15 ] and phase change materials. [ 16–18 ]…”
Section: Introductionmentioning
confidence: 99%
“…Metasurfaces have emerged as one of the most exciting research directions in optics, where light scattering properties of materials can be controlled at will by designing subwavelength structures (“meta‐units”) that strongly interact with the incident light. [ 1–8 ] While originally only enabling static functionality, [ 9 ] these concepts have recently been extended towards active optical devices by employing tunable metasurfaces for sensing and light focusing applications, where the optical response can be controlled using light inclination, [ 10–12 ] stretchable substrates, [ 13 ] electrostatic biasing of two‐dimensional (2D) materials such as graphene, [ 14,15 ] and phase change materials. [ 16–18 ]…”
Section: Introductionmentioning
confidence: 99%
“…gaining popularity. Several developments in ML over the past few years has motivated the researchers to explore its potential in the field of photonics, including multimode fibers [5], power splitter [6], plasmonics [7], grating coupler [8], photonic crystals [9], [10], metamaterials [11], photonic modes fields distribution [12], label-free cell classification [13], molecular biosensing [14], optical communications [15], [16] and networking [17], [18].…”
mentioning
confidence: 99%
“…In addition, AI techniques have also been employed for the inverse design of nanophotonic devices. After being trained with random initial populations of nanostructure geometries and their known spectra, the deep neural networks (DNNs) are able to predict the spectral response of new nanostructure designs, as well as design new nanostructures based on the wanted spectral response [254,255].…”
Section: Discussionmentioning
confidence: 99%