Meteorin-like protein overexpression ameliorates fulminant hepatitis in mice by inhibiting chemokine-dependent immune cell infiltration

Du, Yanan; Teng, Jiaming; Zhou, Tianyu; Du, Bingying; Cai, Wei

doi:10.1038/s41401-022-01049-4

Cited by 9 publications

(2 citation statements)

References 30 publications

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“… 17 , 18 However, information is not available regarding the role of Metrnl in NAFLD/MAFLD. Only Du et al 19 reported that Metrnl overexpression can effectively ameliorate fulminant hepatitis in mice. Considering the role of Metrnl in inflammation and metabolic disorders, we tried to assess the clinical relevance of Metrnl in patients with MAFLD.…”

Section: Introductionmentioning

confidence: 99%

Serum Metrnl is Decreased in Metabolic Dysfunction-Associated Fatty Liver Disease: A Case-Control Study

Liu,

Gao,

Tian

et al. 2024

DMSO

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Context Metrnl is a novel adipokine mainly produced by white adipose tissue, which plays important roles in insulin sensitization, and energy homeostasis. However, information about the function of Metrnl in Metabolic dysfunction-associated fatty liver disease (MAFLD) remains unclear. Methods This is a control study, which enrolled 176 adults with MAFLD and 176 normal controls. They were matched in body mass index (BMI), age, and sex. Serum Metrnl was determined by ELISA. Other biochemical data were also collected. Results Compared to the controls, circulating Metrnl was prominently decreased in the MAFLD adults ( P <0.001). Next, binary logistic regression model indicated that sex, waist circumference (WC), triglyceride, γ-gamma glutamyl transferase(γ-GGT), and Metrnl was independently associated with MAFLD. Further, as Metrnl levels elevated across its tertiles, the rate of MAFLD decreased (67.52, 66.95, and 15.38%; P value for trend<0.001). Data from multivariate logistic regression models evidenced that compared with the lowest tertile of Metrnl, the odds ratio of MAFLD was 0.023(95% CI 0.006–0.086, P <0.001) for the highest tertile after adjusting for potential confounders. Besides, area under ROC curve of Metrnl for diagnosis MAFLD was 0.755(95% CI 0.705–0.805). Metrnl was positively correlated with diastolic blood pressure, WC, BMI, systolic blood pressure, γ-GGT, and Creatinine in MAFLD. Finally, we found systolic blood pressure and Creatinine were independently related to serum Metrnl in MAFLD. Conclusion Serum Metrnl is reduced in adult with MAFLD. The results suggest that Metrnl may be a protective factor associated with the pathogenesis of MAFLD.

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Section: Introductionmentioning

confidence: 99%

Serum Metrnl is Decreased in Metabolic Dysfunction-Associated Fatty Liver Disease: A Case-Control Study

Liu,

Gao,

Tian

et al. 2024

DMSO

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“…Metrnβ is a novel secreted cytokine/myokine first identified in 2012. Metrnβ was reported to be predominantly produced by activated macrophages and barrier tissues, and has been implicated in numerous diseases, ranging from metabolic disorders like diabetes and obesity [ 7 ], to inflammatory diseases like fulminant hepatitis, skin wound healing, psoriasis, prurigo nodularis, actinic keratosis, as well as regeneration [ 8 , 9 , 10 ]. Currently, the biologic functions of Metrnβ mainly focused on its roles as a myokine.…”

Section: Introductionmentioning

confidence: 99%

Elevation of Metrnβ and Its Association with Disease Activity in Systemic Lupus Erythematosus

Zhang,

Cai,

et al. 2023

IJMS

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Systemic lupus erythematosus (SLE) is an auto-immune disease, the pathogenesis of which remains to be fully addressed. Metrnβ is a novel cytokine involved in the pathogenesis of inflammatory disease, but its regulatory roles in SLE are unclear. We aimed to comprehensively investigate the clinical value of Metrnβ in SLE. A massive elevation of circulating Metrnβ levels was observed in SLE, and patients with an active phase displayed higher Metrnβ concentrations than those with inactive phases. Additionally, we found that Metrnβ expression was positively correlated with clinical indicators of SLE. Longitudinal cytokine and chemokine profiles revealed a disturbed immune response in SLE, with high activity profiles displayed severe pathogenic inflammation, and a positive correlation of the serum Metrnβ with CXCL9, IL10, IL18 and IL1RA was observed as well. Moreover, Metrnβ expressions exhibited an inverse correlation with Treg and B10. Of note, a significant decrease of ILC2 was found in SLE, and there was a negative correlation of Metrnβ with ILC2 as well. Further ROC analysis showed that the area under the curve (AUC) for Metrnβ was 0.8250 (95% CI: 0.7379–0.9121), with a cutoff value of 1131 pg/mL to effectively distinguish SLE patients from healthy controls. Our study herein demonstrated for the first time that Metrnβ values were increased and were immunologically correlated with SLE activity, which could be utilized as an alternative biomarker for the early identification and predicting of the immuno-response of SLE.

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N-Acetylcysteine may exert hepatoprotective effect by regulating Meteorin-Like levels in Adriamycin-induced liver injury

Kaya,

Yalcın,

Tektemur

et al. 2023

Cell Stress and Chaperones

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Meteorin-like protein overexpression ameliorates fulminant hepatitis in mice by inhibiting chemokine-dependent immune cell infiltration

Cited by 9 publications

References 30 publications

Serum Metrnl is Decreased in Metabolic Dysfunction-Associated Fatty Liver Disease: A Case-Control Study

Serum Metrnl is Decreased in Metabolic Dysfunction-Associated Fatty Liver Disease: A Case-Control Study

Elevation of Metrnβ and Its Association with Disease Activity in Systemic Lupus Erythematosus

N-Acetylcysteine may exert hepatoprotective effect by regulating Meteorin-Like levels in Adriamycin-induced liver injury

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