Metered-dose inhaler formulation of fluticasone-17-propionate micronized with supercritical carbon dioxide using the alternative propellant HFA-227

Investigations into the Formulation of Metered Dose Inhalers of Salmeterol Xinafoate and Fluticasone Propionate Microcrystals

“…Aggregation of FP was essentially identical regardless of the microparticle type which was formulated. This contrasted to a previous study, where elongated FP particles (identified to be of a different solid state form) demonstrated greater aggregation than mFP in HFA 227 (29).…”

Nanomedicine in pulmonary delivery

“…Because most of the drugs (eg, asthma drugs) are not soluble in CO 2 , SAS processes provide an easy and excellent way to produce dry powder inhalation formulations. 163,164 SFEE can provide uniform crystalline drug nanoparticles, composite nanoparticles containing polymeric materials and the drugs, and nanosuspensions. 165,166 For instance, Chattopadhyay and colleagues 23 used a continuous SFEE method to produce nanoparticle suspensions containing one of three lipids (tripalmitin, tristearin, or gelucire 50/13), and one of two model drugs (indomethacin or ketoprofen).…”

“…23,161,162 Supercritical fluid technology can be divided into several classes. The most important two are supercritical antisolvent precipitation (SAS) 163,164 and supercritical fluid extraction of emulsions (SFEE). 165,166 The fundamental mechanism of SAS is based on rapid precipitation when a drug solution is brought into contact with a supercritical CO 2 .…”

Physical Properties of Supercritically-Processed and Micronised Powders for Respiratory Drug Delivery

“…The benefits of SCF-processed particles in both DPI and MDI formulations have been demonstrated. For example, particles of several steroid drugs were produced by direct spraying of drug solutions into the medium of scCO 2 [3] and an increase of fine particle fraction (FPF ) for steroid formulations prepared with lecithin for an MDI was observed [3,4]. Protein powders were also prepared and tested using this method for DPI applications [5].…”