Polycystic ovary syndrome (PCOS) is known as the most common endocrine/metabolic disorder in women of reproductive age, where it is reported that PCOS affects 5 to 26 percent of women (based on the applied diagnostic criteria) around the world. 1,2 PCOS was found to be associated with different diseases such as metabolic syndrome, type 2 diabetes, hypertension, cardiovascular diseases and even ovulatory infertility. 3,4 There are four distinguished subtypes; inflammatory, hidden cause and finally, pill-induced PCOS and insulin-resistant (the most prevalent type). 5,6 Although the complete etiology of the syndrome remains unclear, the genetic, epigenetic, environmental factors and lifestyle have been associated with PCOS causality. In clinical and/or biochemical settings, diagnosis is based on whether the patient shows no less than two out of three main symptoms, including cysts in the ovaries, high androgen levels and irregular periods. Despite the controversial opinions of current diagnostic criteria of PCOS, an expert opinion from the ultrasound, pelvic exam and blood tests can confirm the diagnosis. 7,8 Blood tests for PCOS are mainly based on hormone levels and endocrine function,