Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination for subfertility associated with polycystic ovary syndrome

Nahuis, Marleen; Costello, Michael; Veen, Fulco van der; Tso, L.O.; Mol, Ben Willem J.; Wely, Madelon van

doi:10.1002/14651858.cd009090.pub2

Cited by 46 publications

(50 citation statements)

References 18 publications

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“…Two RCTS comparing the use of placebo versus metformin in ovulation induction with gonadotrophins for women with PCOS have shown a higher live birth rate (OR 2.31) in the metformin and gonadotrophin group compared with the placebo and gonadotrophin group, however the numbers studied were small [24,25]. There was no observed increase in multiple pregnancy rates in these studies or others looking at clinical pregnancy rates only, with the addition of metformin [26].…”

Section: Metforminmentioning

confidence: 76%

Fertility Treatment for Women with PCOS

Langdon¹,

Pontré²,

Hart³

2017

Testes and Ovaries - Functional and Clinical Differences and Similarities

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Polycystic ovarian syndrome is the commonest cause of anovulatory infertility. This chapter will explore fertility treatment options for this condition including the risks, benefits and success rates for different treatment methods. The importance of close patient monitoring with hormone levels and pelvic ultrasounds to ensure mono-ovulation and to avoid ovarian hyperstimulation syndrome will be highlighted.

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Section: Metforminmentioning

confidence: 76%

Fertility Treatment for Women with PCOS

Langdon¹,

Pontré²,

Hart³

2017

Testes and Ovaries - Functional and Clinical Differences and Similarities

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“…The country of origin of the authors included China (n = 11), [29][30][31][32][33][34][35][36][37][38][39] Australia (n = 6), [40][41][42][43][44][45] United Kingdom (n = 5), 43,[45][46][47][48] the United States of America (n = 4), [49][50][51][52] India (n = 3), 44,52,53 Canada (n = 3), 50,54,55 Brazil (n = 2), 41,56 Iran (n = 2), 40,54 Columbia (n = 1), 46 Greece (n = 1), 57 Italy (n = 1), 57 Spain (n = 1), 58 Scotland (n = 1), 59 Luton (n = 1), 48 Netherlands (n = 1) 41 and Saudi Arabia (n = 1). 46 Thirteen reviews explicitly included randomized control trials (RCTs) only [29][30][31][32]34,36,38,42,43,…”

Section: Study Characteristicsmentioning

confidence: 99%

Pharmacological and surgical treatment of nonreproductive outcomes in polycystic ovary syndrome: An overview of systematic reviews

Tay

Joham

Hiam

et al. 2018

Clinical Endocrinology

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“…On the other hand, evidence has been provided that metformin in combination with clomiphene citrate increases the ovulation and pregnancy rates in women with PCOS, who demonstrated resistance to clomiphene [13][14][15]. However, based on systematic reviews regarding the use of metformin for infertility treatment in PCOS, no conclusive evidence exists that this drug improves the clinical outcome [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Metformin on the Endometrium of Women with Polycystic Ovary Syndrome

Dragamestianos

Messini

Antonakis

et al. 2018

Gynecol Obstet Invest

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Objectives: To investigate the effect of metformin on endometrial receptivity in women with polycystic ovary syndrome (PCOS). Methods: Twenty volunteer women with polycystic ovaries and oligomenorrhea were prospectively investigated. All women were treated with exogenous estradiol and progesterone to simulate a normal menstrual cycle (28-day duration) after GnRH-induced pituitary desensitization. Ten of the women received no other medication (group A, control), while the remaining 10 received metformin (group B, metformin). Endometrial biopsy was performed in all women on day 21 of the 2 simulated cycles. Results: The expression of corticotropin – releasing hormone and urocortin in the endometrium was investigated. There was no significant difference between the 2 groups. A 3-day delay in the secretory maturation of the glandular epithelium relatively to the stroma was observed in 7 out of 10 women of group B (70%) as compared to only 1 out of 10 women of group A (10%, p = 0.02). Conclusions: It is shown for the first time that metformin administration to women with PCOS did not affect the expression of endometrial receptivity markers but delayed histological glandular maturation. It is suggested that metformin may have an impact on the function of the endometrium in PCOS.

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Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination for subfertility associated with polycystic ovary syndrome

Abstract: Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination for subfertility associated with polycystic ovary syndrome.

Cited by 46 publications

References 18 publications

Fertility Treatment for Women with PCOS

Fertility Treatment for Women with PCOS

Pharmacological and surgical treatment of nonreproductive outcomes in polycystic ovary syndrome: An overview of systematic reviews

The Effect of Metformin on the Endometrium of Women with Polycystic Ovary Syndrome

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