Metformin for Obesity in Prepubertal and Pubertal Children: A Randomized Controlled Trial

Abstract

“Metformin decreased the BMI z score and improved inflammatory and cardiovascular-related obesity parameters only in prepubertal children, but a differential effect of metformin was not observed in prepubertal compared to pubertal children. Nevertheless, the doses per kilogram of weight administrated may have had an impact on the metformin effect. Further investigations are necessary.”

Metformin Therapy Reduces Obesity Indices in Children and Adolescents: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

“…All included studies were written in English and published between 2001 and 2017. Among these 38 included studies, 10 studies were done in Europe, 12,20,23,25,31,34,42,44,48,49 20 in the United States and Canada, 10,17,18,21,22,24,29,30,33,35,36,[39][40][41]43,45,47,50,51 3 in Middle America, 11,27,28 1 in Africa (Egypt), 26 and the remaining 2 studies in Asia (Iran). 19,46 In addition, two studies were done among populations from different countries.…”

“…19,46 In addition, two studies were done among populations from different countries. 32,37 Out of included studies, 12 studies were performed in children 17,25,27,28,31,32,39,40,42,[44][45][46]51 and 25 studies in adolescents. [10][11][12][18][19][20][21][22][23][24]26,29,30,[33][34][35][36][37][38]41,43,[47][48][49][50] In addition, six studies were conducted in female participants, 21,26,30,31,44,47 while the others recruited participants from both genders.…”

“…[10][11][12][17][18][19][20][22][23][24][25][27][28][29][32][33][34][35][36][37][38][39][40][41][42][43]45,46,[48][49][50][51] Among in-cluded studies, one study had an open-label design. 42 Control groups received no intervention, 26,31,39,44 placebo, [10][11][12][17][18][19][20][21][22][23]25,[27][28][29][30]…”

“…42 Control groups received no intervention, 26,31,39,44 placebo, [10][11][12][17][18][19][20][21][22][23]25,[27][28][29][30][32][33][34][35][36][37][38]41,43,[45][46][47][48][49][50][51] and diet or exercise 24,39,40,42 in these studies. Participants of these studies had obesity 11,17,20,22,24,27,33,34,40,43,[45][46]…”

“…Moreover, duration of intervention was varied from 12 to 192 weeks. Among included studies, 28 studies measured participants' body weight, 11,12,[17][18][19][20]22,23,25,[26][27][28][31][32][33][34][35][36][37][39][40][41][42][43]45,47,48,51 36 studies measured BMI, [10][11][12][17][18][19][20][21][22][23][24][26][27][28][29][30][31][32][34][35][36][38][39]…”