Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway–mediated neuroinflammation in db/db mice

Hu, Tian; Wei, Jun-Wen; Zheng, Jia-Yi; Luo, Qing-Yi; Hu, Xin-Rui; Du, Qun; Cai, Ye-Feng; Zhang, Shi-Jie

doi:10.1007/s00109-024-02465-1

J Mol Med

2024

DOI: 10.1007/s00109-024-02465-1

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Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway–mediated neuroinflammation in db/db mice

Tian Hu,

Jun-Wen Wei,

Jia-Yi Zheng

et al.

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Cited by 4 publications

References 60 publications

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Microglial activation and polarization in type 2 diabetes-related cognitive impairment: A focused review of pathogenesis

Tian,

Jing,

et al. 2024

Neuroscience & Biobehavioral Reviews

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Microglial activation and polarization in type 2 diabetes-related cognitive impairment: A focused review of pathogenesis

Tian,

Jing,

et al. 2024

Neuroscience & Biobehavioral Reviews

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Metformin activates the PI3K/AKT/BDNF axis to attenuate postoperative cognitive dysfunction

Wu,

Jia,

Zhang

et al. 2025

Neuropharmacology

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Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus

Zgutka,

Tkacz,

Grabowska

et al. 2025

Pharmaceuticals

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Gestational diabetes mellitus (GDM) imposes serious short- and long-term health problems for the mother and her child. An effective therapeutic that can reduce the incidence of GDM and improve long-term outcomes is a major research priority and is very important for public health. Unfortunately, despite numerous studies, the molecular mechanisms underlying GDM are not fully defined and require further study. Chronic low-grade inflammation, oxidative stress, and insulin resistance are central features of pregnancies complicated by GDM. There is evidence of the involvement of sirtuins, which are NAD+-dependent histone deacetylases, in energy metabolism and inflammation. Taking these facts into consideration, the role of sirtuins in the pathomechanism of GDM will be discussed.

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Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway–mediated neuroinflammation in db/db mice

Cited by 4 publications

References 60 publications

Microglial activation and polarization in type 2 diabetes-related cognitive impairment: A focused review of pathogenesis

Microglial activation and polarization in type 2 diabetes-related cognitive impairment: A focused review of pathogenesis

Metformin activates the PI3K/AKT/BDNF axis to attenuate postoperative cognitive dysfunction

Sirtuins and Their Implications in the Physiopathology of Gestational Diabetes Mellitus

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