Metformin improves fibroblast metabolism and ameliorates arthrofibrosis in rats

Innovation and Translation of Biological and Biomaterial Treatment for Challenging Musculoskeletal Disorders

“…In order to develop targeted treatment with good efficacy for injury and disease in the musculoskeletal system, we need to understand molecular and cellular mechanism underlying the bone and joint diseases. In this volume, several relevant works are published with focus on above aspects, including HIF-1α dependent RhoA as a novel therapeutic target regulates rheumatoid arthritis fibroblast-like synoviocytes migration using not only in vitro but also in vivo experimental models [ 1 ]; upregulation of AKT/GSK-3β/β-catenin signalling is crucial for eurycomanone to stimulate bone mineralization and promote osteogenic differentiation of mesenchymal stem cells using zebrafish model [ 2 ]; the role of local sympatholysis on bone-tendon interface healing in a murine rotator cuff repair model [ 3 ]; how metformin improved fibroblast metabolism in ameliorating arthrofibrosis using rat model [ 4 ]; why depletion of Gli1 can induce oxidative stress and apoptosis of nucleus pulposus cells in intervertebral disc degeneration [ 5 ]; Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency through inhibition of NF-κB inflammatory pathway using mouse experimental model [ 6 ]; how osteocyte β3 integrin promotes bone mass accrual and force-induced bone formation through establishing relevant experimental model in mice [ 7 ]; why down-regulation of the RAGE-JAK2-STAT1 signal axis is a relevant underlying mechanism of metformin in attenuating diabetes-induced osteopenia in rat model [ 8 ]; and HMGB1 deubiquitination plays an important role for USP7 to promote osteoclast differentiation of CD14+ human peripheral blood monocytes in osteoporosis [ 9 ]. Nevertheless, in the future more efforts shall be made to validate relevant discoveries for moving towards invention and clinical application.…”