Metformin in selected malignancies in women

Markowska, Anna; Stanisławiak-Rudowicz, Joanna; Kasprzak, Tomasz; Markowska, Janina; Szarszewska, Monika

doi:10.5603/gp.a2021.0222

Cited by 3 publications

(2 citation statements)

References 47 publications

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“…For instance, both diabetic and non-diabetic women with insulin resistance have higher risk to develop breast, endometrial and ovarian cancer, and results from studies in ovarian and cervical cancer suggest that the first-line type 2 diabetes drug and anti-insulin resistance agent metformin is a good candidate in combination therapies for these cancers ( 4 , 9 ). Studies have shown that metformin has antitumor activity in the major gynecologic malignancies through a pleiotropic mechanism involving direct silencing of IGF-1R signaling and indirect silencing of this signaling pathway by targeting its downstream targets, including MAPK and mTOR ( 21 , 22 ). Metformin also induced a G1-cell cycle arrest and apoptosis in EML 4 -ALK(+) lung cancer (H3122) cells partly through the modulation of IGF-1 expression ( 23 ).…”

Section: Igf-1r Signaling: a Key Link Between Metabolic Syndrome And ...mentioning

confidence: 99%

Insulin-like growth factor-1 signaling in the tumor microenvironment: Carcinogenesis, cancer drug resistance, and therapeutic potential

Kamdje¹,

Etet

Kipanyula

et al. 2022

Front. Endocrinol.

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The tumor microenvironment fuels tumorigenesis and induces the development of resistance to anticancer drugs. A growing number of reports support that the tumor microenvironment mediates these deleterious effects partly by overexpressing insulin-like growth factor 1 (IGF-1). IGF-1 is known for its role to support cancer progression and metastasis through the promotion of neovascularization in transforming tissues, and the promotion of the proliferation, maintenance and migration of malignant cells. Anti-IGF therapies showed potent anticancer effects and the ability to suppress cancer resistance to various chemotherapy drugs in in vivo and in vitro preclinical studies. However, high toxicity and resistance to these agents are increasingly being reported in clinical trials. We review data supporting the notion that tumor microenvironment mediates tumorigenesis partly through IGF-1 signaling pathway. We also discuss the therapeutic potential of IGF-1 receptor targeting, with special emphasis on the ability of IGF-R silencing to overcome chemotherapy drug resistance, as well as the challenges for clinical use of anti-IGF-1R therapies.

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Section: Igf-1r Signaling: a Key Link Between Metabolic Syndrome And ...mentioning

confidence: 99%

Insulin-like growth factor-1 signaling in the tumor microenvironment: Carcinogenesis, cancer drug resistance, and therapeutic potential

Kamdje¹,

Etet

Kipanyula

et al. 2022

Front. Endocrinol.

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“…Zarażenie w okresie 2-3 miesięcy przed zapłodnieniem niesie niewielkie ryzyko uszkodzenia płodu. Sugeruje się jednak wstrzymanie planowania ciąży na 6 miesięcy, po ostrej infekcji spowodowanej Toxoplasma gondii[31,32].Biorąc pod uwagę rodzaj podejrzewanego zarażenia -wrodzone lub nabyte -do badań laboratoryjnych pobiera się różny materiał kliniczny. Przy podejrzeniu toksoplazmozy nabytej głównym materiałem jest krew pacjenta, ale może to być również bioptat węzłów chłonnych, szpik kostny, płyn mózgowo-rdzeniowy, bioptat tkanki mózgowej.…”

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Could Toxomplasma gondii infection be dangerous? - Systematic review

Frącz,

Kuliga,

Kuliga

et al. 2023

J Educ Health Sport

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Introduction: Toxoplasma gondii is an intracellular protozoan commonly found in humans in the form of three main forms: tachyzoite, tissue cyst and oocyst. The definitive host is the Felidae family, and one of the intermediate hosts is humans. The most common routes of infection are ingestion of raw or undercooked meat, water and food contaminated with oocysts. Among the forms of infection, we distinguish between the acquired form and the much more dangerous congenital form. Aim of the study: The objective of the study was to rewiev the literature describing the dangerous impact of Toxoplasma gondii infection on human.Methods and materials: : We reviewed the literature available in the PubMed database, using the key words: "toxoplasma gondii"; "congenital toxoplasmosis"; "pregnacy".Results: T. gondii infection is particularly dangerous in pregnant women, due to the high risk of vertical transmission of the infection to the developing fetus. The clinical presentation of congenital toxoplasmosis depends on the gestational age at which the infection occurred. Pathognomonic signs of congenital toxoplasmosis include Sabin-Pinkerton Triad, which includes inflammation of the retina and choroid of the eye, dilatation of the brain's ventricular system and intracranial calcifications. Available pharmacotherapy works on tachyzoites present in the initial phase of acquired infection, congenital infection and reactivated infection in immunodeficient patients, available drugs do not work on tissue cysts.Conclusion: The consequences of Toxoplasma gondii infection are particularly dangerous for the fetus, so pregnant women should pay special attention to hand hygiene and thorough washing of the food they eat. For this reason, it is extremely important to educate pregnant women about health issues and draw attention to the possible consequences of T.gondii infection.

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