Metformin Induces Cytotoxicity in Oral Squamous Cell Carcinoma Cells by Targeting CCN1/Akt-Axis

Zhang, Ling; Sun, Qijun; Ou, Yuejian; Zhang, Qing; Hu, Jian

doi:10.3923/ijp.2022.182.189

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2024

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“…Cellular communication network factor 1 (CCN1/Cyr16) is a regulatory protein of the tumor microenvironment and is over-expressed in many cancers including HNSCC ( 107 ). Metformin reduces Cyr16 and its downstream target p-AKT resulting in a reduction in cell viability in cell line SCC25 ( 108 ) ( Figure 12 ).…”

Section: Discussionmentioning

confidence: 99%

The mechanisms of action of metformin on head and neck cancer in the pre-clinical setting: a scoping review

Huang,

Woods,

Dharmawardana

et al. 2024

Front. Oncol.

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This scoping review identifies the mechanistic pathways of metformin when used to treat head and neck cancer cells, in the pre-clinical setting. Understanding the underlying mechanisms will inform future experimental designs exploring metformin as a potential adjuvant for head and neck cancer. This scoping review was conducted according to the Joanna-Briggs Institute framework. A structured search identified 1288 studies, of which 52 studies fulfilled the eligibility screen. The studies are presented in themes addressing hallmarks of cancer. Most of the studies demonstrated encouraging anti-proliferative effects in vitro and reduced tumor weight and volume in animal models. However, a few studies have cautioned the use of metformin which supported cancer cell growth under certain conditions.

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Section: Discussionmentioning

confidence: 99%