Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights

Nyane, Ntsoaki Annah; Tlaila, Thabiso Bethwel; Malefane, Tanki Gabriel; Ndwandwe, Dudu Edith; Owira, Peter M. O.

doi:10.1016/j.ejphar.2017.03.042

Cited by 75 publications

(45 citation statements)

References 142 publications

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“…In agreement with our results, other natural compounds obtained from stem barks and roots, such as cinnamaldehyde and apocynin, reduced the glucose production and levels of this gluconeogenic enzyme in the kidney of diabetic animals . Similarly, cocoa, tea, EC, and other flavonoids such as naringenin and resveratrol have been reported to modulate the gluconeogenesis in different cultured cell lines and animal models of diabetes and obesity …”

Section: Discussionsupporting

confidence: 92%

(‐)‐Epicatechin and the Colonic 2,3‐Dihydroxybenzoic Acid Metabolite Regulate Glucose Uptake, Glucose Production, and Improve Insulin Signaling in Renal NRK‐52E Cells

Álvarez-Cilleros

Martín

Ramos

2018

Molecular Nutrition Food Res

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Section: Discussionsupporting

confidence: 92%

(‐)‐Epicatechin and the Colonic 2,3‐Dihydroxybenzoic Acid Metabolite Regulate Glucose Uptake, Glucose Production, and Improve Insulin Signaling in Renal NRK‐52E Cells

Álvarez-Cilleros

Martín

Ramos

2018

Molecular Nutrition Food Res

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“…Similarly to Ref. , our results showed the antioxidant effect of NRG through induction of Nrf2 and HO‐1, which act as scavenging lipid peroxidation, leading to preserving the vascular cells from damage. Another study reported that NRG has increased the membrane fluidity near the hydrophilic surface in erythrocytes inhibiting them from being ruptured.…”

Section: Discussionsupporting

confidence: 84%

The effect of naringenin on the role of nuclear factor (erythroid‐derived 2)‐like2 (Nrf2) and haem oxygenase 1 (HO‐1) in reducing the risk of oxidative stress‐related radiotoxicity in the spleen of rats

Abdel‐Magied

Shedid

2019

Environmental Toxicology

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The present study was to evaluate the radiomitigative effect of naringenin (NRG) on the modulation of ionizing radiation (IR)‐induced spleen injury. Rats were exposed to 12 Gy (3Gy/two times/week). NRG (50mg/Kg), was orally given one hour after the first radiation dose, and daily continued during the irradiation period. Rats were sacrificed 1 day after the last dose of radiation. NRG showed a significant decrease of malondialdehyde, hydrogen peroxide with a significant elevation of superoxide dismutase, catalase and glutathione peroxidase activities and glutathione content. Moreover, NRG confirmed the intracellular defense mechanisms through activation of nuclear factor (erythroid‐derived 2)‐like2 (Nrf2) and haem oxygenase‐1 (HO‐1) levels and their protein expression. In addition, NRG deactivated the nuclear factor‐κB (NF‐κB) and reduced the pro‐inflammatory cytokines. Further, NRG showed positive modulation in the haematological values (WBCs, RBCs, Hb, Hct% and PLt). In conclusion, these results suggested that NRG reversed the IR‐induced redox‐imbalance in the rat spleen.

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“…Naringenin, a flavonoid found in high concentrations in yellow citrus fruits, has been reported to have several beneficial effects, one of which involves antidiabetic activity. From a mechanistic point of view, naringenin has been shown to inhibit gluconeogenesis by upregulating AMPK [134], in addition to its influence on improving metabolic disturbances as shown in ovariectomized mice [135].…”

Section: Citrus Fruits (Lemons)mentioning

confidence: 99%

A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for “Eating the Rainbow”

Minich

2019

Journal of Nutrition and Metabolism

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Over the past decades, thousands of published studies have amassed supporting recommendations to consume fruits and vegetables for physiological and psychological health. Newer research has emerged to suggest that these plant-based foods contain a plethora of not only vitamins and minerals, but perhaps, most importantly, phytonutrients. These phytonutrients have known pleiotropic effects on cellular structure and function, ultimately resulting in the modulation of protein kinases and subsequent epigenetic modification in a manner that leads to improved outcomes. Even though eating fruits and vegetables is a well-known feature of a healthy dietary pattern, population intakes continue to be below federal recommendations. To encourage consumers to include fruits and vegetables into their diet, an “eat by color” approach is proposed in this review. Although each individual food may have numerous effects based on its constituents, the goal of this simplified approach was to identify general patterns of benefits based on the preponderance of scientific data and known mechanisms of food-based constituents. It is suggested that such a consumer-oriented categorization of these plant-based foods may lead to greater recognition of their importance in the daily diet throughout the lifespan. Other adjunctive strategies to heighten awareness of fruits and vegetables are discussed.

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Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights

Cited by 75 publications

References 142 publications

(‐)‐Epicatechin and the Colonic 2,3‐Dihydroxybenzoic Acid Metabolite Regulate Glucose Uptake, Glucose Production, and Improve Insulin Signaling in Renal NRK‐52E Cells

(‐)‐Epicatechin and the Colonic 2,3‐Dihydroxybenzoic Acid Metabolite Regulate Glucose Uptake, Glucose Production, and Improve Insulin Signaling in Renal NRK‐52E Cells

The effect of naringenin on the role of nuclear factor (erythroid‐derived 2)‐like2 (Nrf2) and haem oxygenase 1 (HO‐1) in reducing the risk of oxidative stress‐related radiotoxicity in the spleen of rats

A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for “Eating the Rainbow”

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