Metformin Loaded Carbopol Gel for lowering the Intra-Abdominal Visceral Fat

Abdellatif, Ahmed A. H.; Tawfeek, Hesham M.

doi:10.4172/jbb.1000286

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…Moreover, the weight reducing function of MET via modulation of lipid metabolism has also attracted more and more attention due to growing serious obesity problems (Abdellatif and Tawfeek 2016). It's widely accepted that the intraabdominal visceral and subcutaneous fat were highly related to obesity (Abdellatif and Tawfeek 2016). To address this problem, Abdellatif et al prepared a MET-loaded carbopol gel using carbopol 934, in order to achieve the local delivery of the drug to the abdomen area for lowering the intra-abdominal visceral fat (Abdellatif and Tawfeek 2016).…”

Section: Nano-dds Of Met For Fat Controlling and Weight Reducingmentioning

confidence: 99%

“…It's widely accepted that the intraabdominal visceral and subcutaneous fat were highly related to obesity (Abdellatif and Tawfeek 2016). To address this problem, Abdellatif et al prepared a MET-loaded carbopol gel using carbopol 934, in order to achieve the local delivery of the drug to the abdomen area for lowering the intra-abdominal visceral fat (Abdellatif and Tawfeek 2016). Compared with MET tablets and control (placebo) groups, topical delivery of MET-loaded carbopol gel demonstrated distinct advantages in decreasing the diameter of the abdomen (Abdellatif and Tawfeek 2016).…”

Section: Nano-dds Of Met For Fat Controlling and Weight Reducingmentioning

confidence: 99%

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Emerging nanoparticulate drug delivery systems of metformin

Chen

Shan

Luo

et al. 2020

J. Pharm. Investig.

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Background Driving the conventional drug in new applications has emerged as a research hotspot for disease treatment. Metformin (MET) is conventionally used for the treatment of type II diabetes. It has also been found to be a versatile molecule with wide biological functions, such as losing weight. anti-aging and anticancer activity. Rational design of nanoparticulate drug delivery systems (nano-DDS) could significantly improve drug delivery efficiency. Recently, a wide range of nano-DDS has been developed to improve the delivery efficacy of MET or to perform as versatile nanoplatforms for efficient drug delivery. Area covered In this review, we outline the emerging trends in advanced nano-DDS of MET, focusing on nano-DDS of MET for diabetes therapy, nano-DDS of MET for anticancer therapeutics, and nano-DDS of MET for other therapeutic aims. Expert opinion Despite the great progression in nano-DDS of MET, there's still a long way to truly put the conventional drug in new applications. Several important issues should be fully taken into consideration, such the manufacturing cost and economic burdens for patients, the biocompatibility and long-term toxicity of carrier materials, scale-up preparation difficulties, as well as the species gap between human beings and animal models.

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Section: Nano-dds Of Met For Fat Controlling and Weight Reducingmentioning

confidence: 99%

Section: Nano-dds Of Met For Fat Controlling and Weight Reducingmentioning

confidence: 99%

Emerging nanoparticulate drug delivery systems of metformin

Chen

Shan

Luo

et al. 2020

J. Pharm. Investig.

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show abstract

“…The ability of drugs to diffuse through membranes is influenced by molecular size. Drugs with high molecular weights usually possess a very low diffusion coefficient and hence a low permeability through many polymeric films [22,48].…”

Section: The Embedded Matrix Principlementioning

confidence: 99%

Design of Sustained Action Dosage Forms; Mini-Review

Abdellatif¹

2018

Pharm Anal Acta

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Greatest idealized per-oral sustained action products have been formulated in the form of oral dosage forms such as capsules or tablets. The characteristic trouble of preparing sustained action liquids has controlled the availability of such dosage forms. Encapsulated long-acting dosage forms have two particular benefits over capsules and tablet designs. Firstly, the inability to be disintegrated which may persist in the stomach for long periods of time, extremely suspending in the stomach and retard the absorption of maintenance dose. Secondly, the disintegration of the capsule shell in the gastric fluid releases particles that pass across the pyloric valve. Also, the release of drug by a meaningful fraction of the granules is highly possible. If a tablet fails to release drug, the entire maintenance dose is lost. This review discusses the different methods for enhancing the sustained drug action. cancer cells, such as the SSTRs, the folate receptor, and transferrin receptors. Moreover, nanoparticles coated cell-penetrating peptides and protein-transduction domains, such as oligoarginine and TAT facilitated the uptake of these nanoparticles which cannot successfully enter cancer cells [8]. This review discusses the different methods for enhancing the sustained drug action, the barrier principle, model based on diffusion, and model based on dissolution. Moreover, the review discusses the principle release from the matrix.

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“…Carbopol 934 hydrogels were prepared by previous reported methods [13,17]. Briefly, carbopol 934 (1%, w/v) was added gradually to a beaker contains an aqueous solution of LOR-GNPs with continuous stirring and heating in a water bath at 50°C until homogenous gel is formed.…”

Section: Preparation Of Hydrogel Loaded Loratadine Nanoparticlesmentioning

confidence: 99%

Formulation of Novel Glycerin Nanoparticles for Enhancement the Solubility of Loratadine; Application to Transdermal Hydrogel Delivery System

Abou-Taleba¹,

Hamdb²,

Abdellatif³

2017

J Nanomed Nanotechnol

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Owing to its slightly aqueous solubility, loratadine (LOR) is used in high doses in different marketed formulations to achieve its desirable bioavailability. The aim of this work is to formulate novel LOR-glycerin nanoparticles (LOR-GNPs) to increase LOR bioavailability. LOR-GNPs were prepared by a precipitation method and then evaluated for such size and morphology using dynamic scattering spectroscopy (DLS) and scanning electron microscopy (SEM), as well as the percentage entrapment efficiency (EE%) of free LOR from GNPs formulations was performed using titration method. Furthermore, the GNPs were formulated in hydrogel. The hydrogel viscosity, spreadability, homogeneity and abdominal rat skin permeation were studied and optimized DLS indicated a successful coating of LOR with glycerin surface that recorded an average size of 334 ± 30 nm with uniform particle size, while SEM showed LOR-NPs in different shapes. The EE% free LOR was found to be satisfactory with a mean content of 98.1 ± 0.3 and a relative standard deviation below 2.0% indicates the reproducibility of the LOR release. LOR-GNPs were formulated as a hydrogel to check their suitability for a dosage form usage. The hydrogel showed accepted viscosity, spreadability, and homogeneity. The results proved that the GNPs penetrated abdominal rat skin. The obtained results showed that LOR-GNPs are considered a new addition for improvement of LOR solubility when applied as a hydrogel. The developed method could be used for different insoluble candidates.

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Metformin Loaded Carbopol Gel for lowering the Intra-Abdominal Visceral Fat

Abstract: Materials and Method MaterialsMetformin hydrochloride is obtained as a gift from CID-Company, Assiut, Egypt. Carbapol 934, sodium hydroxide and methyl Paraben

Cited by 7 publications

References 20 publications

Emerging nanoparticulate drug delivery systems of metformin

Emerging nanoparticulate drug delivery systems of metformin

Design of Sustained Action Dosage Forms; Mini-Review

Formulation of Novel Glycerin Nanoparticles for Enhancement the Solubility of Loratadine; Application to Transdermal Hydrogel Delivery System

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