2020
DOI: 10.1007/s43440-020-00095-1
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Metformin protects rotenone-induced dopaminergic neurodegeneration by reducing lipid peroxidation

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Cited by 24 publications
(6 citation statements)
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“…Moreover, in order to investigate the effect of Myr on fibril-mediated oxidative stress, we quantified the production of malondialdehyde, an advanced lipo-oxidation end-product implicated in age-related chronic diseases and in PD [ 46 ].…”
Section: Resultsmentioning
confidence: 99%
“…Moreover, in order to investigate the effect of Myr on fibril-mediated oxidative stress, we quantified the production of malondialdehyde, an advanced lipo-oxidation end-product implicated in age-related chronic diseases and in PD [ 46 ].…”
Section: Resultsmentioning
confidence: 99%
“…In C. elegans, metformin reduced the loss of dopaminergic neurons and decreased α-synuclein aggregation induced by 6-hydroxydopamine (94). Recently, metformin treatment was shown to attenuate dopaminergic cell loss and α-synuclein accumulation in the SN of rotenone-treated mice (95). How metformin alters α-synuclein toxicity is not clear but the drug is able reduce the phosphorylation of the protein that is key to the mediation of its toxicity (96).…”
Section: α-Synuclein Aggregation and Phosphorylationmentioning
confidence: 99%
“…Hence, we recently speculated that metformin could provide a similar scavenging activity towards MGO by preventing the accumulation of α-syn neurotoxic aggregates, but this could be extended to other aldehydes of neuropathological relevance in PD, i.e., aldehydes derived from oxidative stress and lipid peroxidation (4-hydroxynonenal (4-HNE), malondialdehyde (MDA)) or aldehydic molecules that accumulate from altered monoamine catabolic pathways (3,4-dihydroxyphenylacetaldehyde, 3,4-dihydroxyphenylglycoaldehyde, 5-hydroxyindole-3-acetaldehyde) [ 42 ]. Accordingly, a recent paper investigated the neuroprotective effect of metformin in a PD mouse model based on rotenone-induced dopaminergic neuron death [ 25 ]. The authors demonstrated that metformin co-administration with rotenone significantly reduced the nigral levels of 4-HNE and MDA, together with decreased α-syn accumulation and dopaminergic neuron degeneration in the SNpc [ 25 ].…”
Section: Potential Neuroprotective Mechanisms Of Action Of Metforminmentioning
confidence: 99%
“…Accordingly, a recent paper investigated the neuroprotective effect of metformin in a PD mouse model based on rotenone-induced dopaminergic neuron death [ 25 ]. The authors demonstrated that metformin co-administration with rotenone significantly reduced the nigral levels of 4-HNE and MDA, together with decreased α-syn accumulation and dopaminergic neuron degeneration in the SNpc [ 25 ]. Although the authors did not investigate it directly, the reduced α-syn buildup might derive, at least in part, from a scavenging activity of metformin towards lipid peroxidation products, preventing α-syn modification and oligomerization.…”
Section: Potential Neuroprotective Mechanisms Of Action Of Metforminmentioning
confidence: 99%