Metformin protects the brain against ischemia/reperfusion injury through PI3K/Akt1/JNK3 signaling pathways in rats

Ge, Xuhua; Zhu, Guoji; Geng, Deqin; Zhang, Hanzhi; He, Juan-Mei; Guo, Aijiang; Ma, Linlin; Yu, Dehua

doi:10.1016/j.physbeh.2016.12.021

Cited by 77 publications

(47 citation statements)

References 53 publications

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“…It is well established that Met has anxiolytic effect. Met has exhibited antistress and anxiolytic‐like activity following global cerebral ischemia and ischemia/reperfusion‐induced brain damage via neuroprotective and antiapoptotic effects . Moreover, Met improves anxiety‐like behaviors in rat model of type‐2 diabetes mellitus via increasing the enzymes of antioxidant system such as SOD and catalase .…”

Section: Discussionmentioning

confidence: 99%

Metformin ameliorates the age‐related changes of d‐galactose administration in ovariectomized mice

Fatemi

Heydari

Kaeidi

et al. 2018

Fundamemntal Clinical Pharma

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Metformin (Met) has been shown to have pleiotropic effects such as neuroprotective, antioxidant, and anti-inflammatory properties making that a potential candidate for the treatment of central nervous system (CNS) disorders. This study was designed to investigate the possible effect of Met on the d-galactose (d-gal)-induced aging in ovariectomized mice. The female mice underwent bilateral ovariectomy. d-gal was administered orally at a dose of 500 mg/kg, and Met was administrated orally at doses of 1 and 10 mg/kg for 6 weeks. Anxiety-like behavior was evaluated by the elevated plus-maze. Physical power was assessed by vertical grid holding test and forced swimming capacity test. The brains were assessed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF). Ovariectomy caused anxiety and declined the physical power as well as BDNF and SOD levels. d-gal administration in ovariectomized mice exacerbated these deleterious effects. Met hampered the anxiety-like behavior and strengthened the physical power of d-gal-treated ovariectomized mice. Met also increased the SOD and BDNF levels in the brains of d-gal-treated ovariectomized animals. Based on the obtained results, we suggest Met administration as a novel therapeutic approach for the treatment of age-related conditions in the absence of female sex hormones.

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Section: Discussionmentioning

confidence: 99%

Metformin ameliorates the age‐related changes of d‐galactose administration in ovariectomized mice

Fatemi

Heydari

Kaeidi

et al. 2018

Fundamemntal Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…In this ovarian torsion/detorsion rat model study, we tried to investigate the possible preservative effect of metformin, as its antioxidant and anti‐inflammatory properties have been mentioned in previous studies . While metformin, a biguanide and antidiabetic drug, is mostly known for its antihyperglycemic effects, its other beneficial effects have recently been observed . Tomczynska et al reported that metformin could be useful for autoimmune disease treatment due to its anti‐inflammatory and antioxidant properties, as well as its ability to regenerate the endothelium .…”

Section: Discussionmentioning

confidence: 99%

“…12,13,16 While metformin, a biguanide and antidiabetic drug, is mostly known for its antihyperglycemic effects, its other beneficial effects have recently been observed. 17 Tomczynska et al reported that metformin could be useful for autoimmune disease treatment due to its anti-inflammatory and antioxidant properties, as well as its ability to regenerate the endothelium. 33 In their animal study, Dai et al observed the effective reduction of oxidative liver damage with metformin.…”

Section: Discussionmentioning

confidence: 99%

“…Charlon et al have reported that administering metformin to rats for 5 days decreased infarct size by nearly 22% . Due to these abilities, metformin has been used in several IRI exams that have reported successful results . Wang et al have reported that low doses of metformin may reduce renal IRI by increasing the supply of energy to the ischemic tissue and reducing the expression of inflammatory cytokines .…”

Section: Introductionmentioning

confidence: 99%

“…16 Due to these abilities, metformin has been used in several IRI exams that have reported successful results. 17,18 Wang et al have reported that low doses of metformin may reduce renal IRI by increasing the supply of energy to the ischemic tissue and reducing the expression of inflammatory cytokines. 19 On the basis of these data, this study aimed to investigate for the first time the possible protective effect of metformin against IRI in rat ovaries by assessing histological and biochemical parameters.…”

Section: Introductionmentioning

confidence: 99%

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