Metformin reduces risk of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during gonadotropin-stimulated in vitro fertilization cycles: a randomized, controlled trial

Palomba, Stefano; Falbo, Angela; Carrillo, Laura Ibernia Vargas; Villani, Maria Teresa; Orio, Francesco; Russo, Tiziana; Cello, Annalisa Di; Cappiello, Fulvio; Capasso, S.; Tolino, Achille; Colao, Annamaria; Mastrantonio, P; Sala, Giovanni Battista La; Zullo, Fulvio; Cittadini, E

doi:10.1016/j.fertnstert.2011.09.020

Cited by 74 publications

(82 citation statements)

References 51 publications

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“…Nevertheless, chronic administration of this drug is usually for nonfertility purposes, while in the present study, the duration of metformin administration was similar to that in our previous study and compatible with that in ovarian stimulation protocols for IVF. In the literature, metformin has been prescribed during ovarian stimulation for IVF even for a shorter period of time than in our study [16,42]. Also, the daily dose of 1,700 mg that we used is widely acceptable [16,43] and was similar to that of our previous study.…”

Section: Discussionsupporting

confidence: 72%

“…Also, the daily dose of 1,700 mg that we used is widely acceptable [16,43] and was similar to that of our previous study. Even a lower daily oral dose of metformin (1,500 mg) given for a shorter period of time than that in our study in the context of a long agonist protocol has been clinically effective by reducing the incidence of the ovarian hyperstimulation syndrome after IVF [42].…”

Section: Discussionmentioning

confidence: 57%

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The Effect of Metformin on the Endometrium of Women with Polycystic Ovary Syndrome

Dragamestianos

Messini

Antonakis

et al. 2018

Gynecol Obstet Invest

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Objectives: To investigate the effect of metformin on endometrial receptivity in women with polycystic ovary syndrome (PCOS). Methods: Twenty volunteer women with polycystic ovaries and oligomenorrhea were prospectively investigated. All women were treated with exogenous estradiol and progesterone to simulate a normal menstrual cycle (28-day duration) after GnRH-induced pituitary desensitization. Ten of the women received no other medication (group A, control), while the remaining 10 received metformin (group B, metformin). Endometrial biopsy was performed in all women on day 21 of the 2 simulated cycles. Results: The expression of corticotropin – releasing hormone and urocortin in the endometrium was investigated. There was no significant difference between the 2 groups. A 3-day delay in the secretory maturation of the glandular epithelium relatively to the stroma was observed in 7 out of 10 women of group B (70%) as compared to only 1 out of 10 women of group A (10%, p = 0.02). Conclusions: It is shown for the first time that metformin administration to women with PCOS did not affect the expression of endometrial receptivity markers but delayed histological glandular maturation. It is suggested that metformin may have an impact on the function of the endometrium in PCOS.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 57%

The Effect of Metformin on the Endometrium of Women with Polycystic Ovary Syndrome

Dragamestianos

Messini

Antonakis

et al. 2018

Gynecol Obstet Invest

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“…Currently, there is a movement away from using HCG as an ovulatory trigger as it seems to be important in the pathogenesis of OHSS. For women with PCOS the use of metformin during controlled ovarian hyperstimulation has been shown to decrease the relative risk of OHSS by O.2; 95% CI without changes the clinical outcomes of implantation rate, pregnancy or live birth rate [25].…”

Section: Treatmentmentioning

confidence: 99%

A Brief Review of Stroke associated with Assisted Reproductive Technology

O’Neal¹

2017

J Neurol Neurophysiol

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Strokes related to assisted reproductive technology are rare, but can be devastating. In order to understand how stroke can occur as a complication of assisted reproductive technology, both the normal physiology of ovulation and the hormonal manipulations used to maximize pregnancy will be examined. In particular, the danger of thrombotic complications related to ovarian hyperstimulation syndrome will be reviewed including the pathophysiology, clinical features, risk factors and treatment.

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“…Studies to date have demonstrated mixed results for metformin administration in PCOS patients undergoing IVF treatment with respect to reproductive outcomes. These studies displayed considerable heterogeneity in terms of patient characteristics, treatment protocols and study settings [8][9][10][11][12][13][14][15][16][17][18][19][20]. Thus, there is a currently a significant degree of uncertainty for the specific role of metformin in IVF therapy.…”

Section: Introductionmentioning

confidence: 99%

Metformin use in patients undergoing in vitro fertilization treatment: results of a worldwide web-based survey

Christianson

Zhao

et al. 2015

J Assist Reprod Genet

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Metformin reduces risk of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during gonadotropin-stimulated in vitro fertilization cycles: a randomized, controlled trial

Cited by 74 publications

References 51 publications

The Effect of Metformin on the Endometrium of Women with Polycystic Ovary Syndrome

The Effect of Metformin on the Endometrium of Women with Polycystic Ovary Syndrome

A Brief Review of Stroke associated with Assisted Reproductive Technology

Metformin use in patients undergoing in vitro fertilization treatment: results of a worldwide web-based survey

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