Metformin therapy in women with polycystic ovary syndrome

Aruna, Janaki; Mittal, Suneeta; Kumar, Sunesh; Misra, Renu; Dadhwal, V.; Vimala, N.

doi:10.1016/j.ijgo.2004.08.015

Cited by 30 publications

(14 citation statements)

References 18 publications

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“…The PCOS status was determined by a single adolescent gynecologist using Rotterdam criteria requiring the presence of at least two of the three criteria of (i) clinical or biochemical evidence evidence of hyperandrogenism; (ii) oligo- or anovulation (defined as less than nine periods per year); and (iii) PCOM [20]. During chart review, we identified girls who also met the National Institutes of Health (NIH) criteria for PCOS [21] requiring the presence of both oligoovulation and hyperandrogenism.…”

Section: Methodsmentioning

confidence: 99%

“…During chart review, we identified girls who also met the National Institutes of Health (NIH) criteria for PCOS [21] requiring the presence of both oligoovulation and hyperandrogenism. Determination of PCOM was based on adult criteria of the presence of 12 or more 2–9 mm follicles in each ovary or ovarian volume >10 mL as defined by Rotterdam criteria [20]. Subjects with untreated hypothyroidism, hyperprolactinemia, congenital adrenal hyperplasia, Cushing’s syndrome, pregnancy, androgen-secreting tumors, or a condition as the cause of hyperandrogenism were excluded.…”

Section: Methodsmentioning

confidence: 99%

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Fasting Glucose Changes in Adolescents with Polycystic Ovary Syndrome Compared with Obese Controls: A Retrospective Cohort Study

Javed

Lteif

Kumar

et al. 2015

Journal of Pediatric and Adolescent Gynecology

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Objective To compare changes in fasting glucose among adolescents with polycystic ovary syndrome (PCOS) to obese adolescents without PCOS. Methods Retrospective cohort study of 310 adolescents with PCOS and 250 obese adolescents, (ages 13–18 years) seen at Mayo Clinic, Rochester MN, from 1996–2012. Included for analysis were 98 adolescents with PCOS and 150 obese adolescents who had 2 or more fasting glucose measurements separated by at least 6 months. Adolescents with impaired fasting glucose or diabetes were excluded. Multivariate models were used to assess predictors of change in fasting glucose. Results At diagnosis, adolescents with PCOS had lower body mass index (BMI) (kg/m2) and older age than obese adolescents (P<.001). Adolescents with PCOS had shorter follow up (years) (P=.02). Baseline fasting glucose (mg/dl) was not different between groups. Mean change in fasting glucose (mg/dl/year) was 2.4± 9.4 mg/dl/year for PCOS and 2.2±6.2 mg/dl/year for obese adolescents (P=.83). Significant predictors for change in fasting glucose were BMI and fasting glucose at diagnosis (P<.01). Within the PCOS cohort, BMI was a significant predictor for development of IFG (P=.003). Prevalence of hypertension (HTN) increased in the PCOS cohort from baseline to follow up (P=.02). PCOS and BMI were significantly associated with development of HTN in the entire cohort. Conclusions Adolescent girls with PCOS do not show a significant change in fasting glucose or an increased risk for the development of IFG compared to obese adolescents. BMI, not PCOS status, was the strongest predictor for changes in fasting glucose and development of IFG over time.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Fasting Glucose Changes in Adolescents with Polycystic Ovary Syndrome Compared with Obese Controls: A Retrospective Cohort Study

Javed

Lteif

Kumar

et al. 2015

Journal of Pediatric and Adolescent Gynecology

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“…Hirsutism has a low prevalence in Taiwanese Chinese women and Hsu et al(30) reported a prevalence of about 28%, whereas Takeshi et al(31), from Japan, noted a prevalence of 8%. On the other hand, Aruna et al(32) described a prevalence of 66% of hirsutism in Indian populations. Although clinical and biochemical hyperandrogenism is less in Japanese women, hypersecretion of LH is more prominent…”

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confidence: 99%

Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial

Zain

Jamaluddin²,

Ibrahim³

et al. 2009

Fertility and Sterility

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“…Metformin does not have an effect on the biochemical parameters of FSH, LH. This differs from some studies showing that metformin reduces the effect of LH and causes an elevation in serum FSH [29] [30] and agreed with studies showing that metformin has no effect on hormonal parameters [20] [31] [32]. Historically, the overall successful pregnancy rates after ovulation induction range from as low as 9% to as high as 25% [33].…”

Section: Discussionmentioning

confidence: 41%

Comparative Study between Metformin and Laparoscopic Ovarian Drilling for Ovulation Induction, Achievement of Pregnancy and Live Birth in Asian Women with Polycystic Ovarian Syndrome: A Prospective Trial

Jahan¹,

Nayer²,

Habib³

et al. 2014

OALib

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Objective: To compare the efficacy of metformin and laparoscopic ovarian drilling to be used in anovulatory patients with polycystic ovarian syndrome (PCOS) for ovulation induction and pregnancy achievement. Materials and Methods: Setting and Design: A prospective clinical trial conducted in the outpatient department of Gynaecology and Obstetrics of BIRDEM hospital from August 2008 to August 2013. Patient(s): Three hundred and eight newly diagnosed patients with PCOS based on ESHRE/ASRM criteria. These patients were assigned to two groups: Group 1 (152 patients) received 500 mg of metformin three times a day; Group 2 (156 patients) received laparoscopic ovarian drilling. Main Outcome Measure(s): Rate of ovulation, pregnancy rate (PR), and live birth. Ovulation was monitored by serum progesterone, transvaginal sonography up to six cycles or till pregnancy occurred upto six months. Result(s): The ovulation rate was 68.4% in the metformin group, 59% in the laparoscopy treatment group. The pregnancy rate was (20.1% and 16.6%) and live birth rate was (18.4% and 15.4%) in metformin and laparoscopy treatment groups, respectively. The rate of spontaneous first trimester loss was three and two in metformin and laparoscopy group respectively. There were no ectopic pregnancies in metformin group and two in laparoscopy group. There was no second trimester pregnancy loss in metformin group, three in laparoscopy group. There were no multiple pregnancies in metformin group, two in lapa-* Corresponding author. S. Jahan et al.OALibJ |

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Metformin therapy in women with polycystic ovary syndrome

Abstract: A 6-month course of metformin therapy may improve menstrual cyclicity and fertility in women with PCOS.

Cited by 30 publications

References 18 publications

Fasting Glucose Changes in Adolescents with Polycystic Ovary Syndrome Compared with Obese Controls: A Retrospective Cohort Study

Fasting Glucose Changes in Adolescents with Polycystic Ovary Syndrome Compared with Obese Controls: A Retrospective Cohort Study

Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial

Comparative Study between Metformin and Laparoscopic Ovarian Drilling for Ovulation Induction, Achievement of Pregnancy and Live Birth in Asian Women with Polycystic Ovarian Syndrome: A Prospective Trial

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