Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome: summary of a Cochrane review

Tso, L.O.; Costello, Michael; Albuquerque, L.E.T.; Andriolo, Régis B; Marjoribanks, Jane; Macedo, Cristiane R

doi:10.1016/j.fertnstert.2015.05.038

Cited by 24 publications

(13 citation statements)

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“…In women with polycystic ovary syndrome or polycystic ovaries, Metformin before or during assisted reproductive technology cycles increases clinical pregnancy rates and decreases the risk of ovarian hyperstimulation syndrome. However, there is no conclusive evidence of benefits in life birth rates ( Tso et al ., 2015 ).…”

Section: Discussionmentioning

confidence: 99%

A healthy HLA-matched baby born by using a combination of aCGH and Karyomapping: the first latin american case

Delgado¹,

Llerena²,

López

et al. 2017

JBRA Assisted Reproduction

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PGD for HLA typing is a procedure that can be performed when an affected child requires a transplant to treat a non-hereditary disorder related to the hematopoietic and/or immune system. Hematopoietic stem cell transplantation from an HLA-identical donor provides the best treatment option. Three conventional ovarian stimulation procedures for IVF were performed in a couple with a 10-year-old child diagnosed with T-cell acute lymphoblastic leukemia of high risk. Trophectoderm biopsy and aCGH examination were performed on 15 blastocysts, three on the first IVF procedure, four on the second cycle, and eight on the third. Three euploid blastocysts HLA-compatible with the genome of the affected child were identified. One euploid blastocyst HLA-compatible with the affected child was warmed and transferred, resulting in an HLA-matched live birth. In conclusion, combined aCGH for aneuploidy screening and Karyomapping may be performed in a single biopsy procedure.

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Section: Discussionmentioning

confidence: 99%

A healthy HLA-matched baby born by using a combination of aCGH and Karyomapping: the first latin american case

Delgado¹,

Llerena²,

López

et al. 2017

JBRA Assisted Reproduction

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“…Bien que l'efficacité de la metformine sur l'amélioration systémique du métabolisme chez les patients souffrant du SOPK ait été confirmée, son effet sur la reproduction reste controversé. Certains chercheurs ont montré que la metformine ne permet pas de restaurer le cycle menstruel, la fertilité, ni d'améliorer les taux de conception après induction de l'ovulation (Palomba et al 2007, Tso et al 2015. Chez les femmes atteintes du syndrome des ovaires polykystiques, le traitement par la metformine avant ou pendant les cycles de reproduction assistée augmente les taux de grossesses cliniques et diminue le risque de syndrome d'hyperstimulation ovarienne.…”

Section: C) Les Agents Insulino-sensibilisateurs Et Le Développement unclassified

Nutrition et métabolisme : quel lien avec le développement folliculaire et embryonnaire ches les mammifères ?

2019

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L’influence du poids et des apports énergétiques sur la fertilité chez les animaux, mais aussi chez l’Homme est reconnue depuis très longtemps. Les animaux ou individus en mauvaise condition, ou perdant du poids, ont généralement des performances reproductives décevantes. Les pertes économiques associées à l’infertilité sont parfois importantes, et dépassent chez le bovin largement le coût de l’insémination et de la semence. De nombreux arguments suggèrent que l’influence de la nutrition sur la reproduction s’exerce par l’intermédiaire des composants du régime alimentaire comme les lipides, le glucose, les acides aminés et les minéraux au niveau de l’axe hypothalamo-hypophysaire et aussi directement au niveau des gonades. Ces effets nutritionnels peuvent aussi s’exercer par une modulation des hormones du métabolisme comme l’insuline, l’insulin-like growth factor 1, l’hormone de croissance, la ghréline, les hormones thyroïdiennes ou encore les hormones produites et secrétées par le tissu adipeux blanc. Dans cette revue nous rapportons les effets connus de ces nutriments et hormones métaboliques sur le développement folliculaire, les cellules ovariennes, la qualité ovocytaire ainsi que sur le développement embryonnaire précoce en prenant l’exemple de différentes espèces de mammifères.

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“…In women with PCOS, metformin treatment before or during assisted reproductive technology increased pregnancy rates and decreased the risk of ovarian hyperstimulation syndrome. However, there is no conclusive evidence of a benefit in live birth rates [ 177 ].…”

Section: The Effects Of Insulin-sensitizing Drugs On Ovarian Functionmentioning

confidence: 99%

Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle

Dupont

Scaramuzzi

2016

Biochemical Journal

161

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Data derived principally from peripheral tissues (fat, muscle and liver) show that insulin signals via diverse interconnecting intracellular pathways and that some of the major intersecting points (known as critical nodes) are the IRSs (insulin receptor substrates), PI3K (phosphoinositide kinase)/Akt and MAPK (mitogen-activated protein kinase). Most of these insulin pathways are probably also active in the ovary and their ability to interact with each other and also with follicle-stimulating hormone (FSH) and luteinizing hormone (LH) signalling pathways enables insulin to exert direct modulating influences on ovarian function. The present paper reviews the intracellular actions of insulin and the uptake of glucose by ovarian tissues (granulosa, theca and oocyte) during the oestrous/menstrual cycle of some rodent, primate and ruminant species. Insulin signals through diverse pathways and these are discussed with specific reference to follicular cell types (granulosa, theca and oocyte). The signalling pathways for FSH in granulosa cells and LH in granulosa and theca cells are summarized. The roles of glucose and of insulin-mediated uptake of glucose in folliculogenesis are discussed. It is suggested that glucose in addition to its well-established role of providing energy for cellular function may also have insulin-mediated signalling functions in ovarian cells, involving AMPK (AMP-dependent protein kinase) and/or hexosamine. Potential interactions of insulin signalling with FSH or LH signalling at critical nodes are identified and the available evidence for such interactions in ovarian cells is discussed. Finally the action of the insulin-sensitizing drugs metformin and the thiazolidinedione rosiglitazone on follicular cells is reviewed.

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Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome: summary of a Cochrane review

Cited by 24 publications

References 0 publications

A healthy HLA-matched baby born by using a combination of aCGH and Karyomapping: the first latin american case

A healthy HLA-matched baby born by using a combination of aCGH and Karyomapping: the first latin american case

Nutrition et métabolisme : quel lien avec le développement folliculaire et embryonnaire ches les mammifères ?

Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle

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