Metformin vs. insulin in gestational diabetes. A randomized study characterizing metformin patients needing additional insulin

Abstract

Metformin is an effective alternative to insulin in the treatment of GDM patients. Serum fructosamine may help in predicting the adequacy of metformin treatment alone.

Is it worth treating gestational diabetes: if so, when and how?

“…Recently, several RCTs have compared metformin and insulin as a treatment of GDM [36][37][38][39][40][41][42]. According to these RCTs, metformin seems to be comparable to insulin as regards glycaemic control and neonatal outcomes, while being associated with less maternal weight gain and lower rates of neonatal hypoglycaemia and, possibly, gestational hypertension.…”

Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem

“…После исследования MIG было опубликовано мно-жество РКИ, посвященных сравнению метформина с инсулином, которые в большинстве своем подтвердили данные MIG [16][17][18][19][20][21][22][23]. Единственным ключевым отли-чием стало отсутствие тенденции к преждевременному родоразрешению в группе пациенток на метформине, которое было показано в MIG.…”

Metformin Vs Insulin for Treatment of Gestational Diabetes-A Randomized Clinical Trial

“…Various studies have shown a wide range of incidence of about 1% to 14%. [3][4][5][6] GDM is associated with increased risk of adverse maternal and neonatal outcomes e.g., it increases the risk of preeclampsia, caesarian section and type 2 diabetes after pregnancy. Regarding neonatal outcomes, it can increase the risk of still birth, neonatal death, congenital defects, macrosomia, neonatal hypoglycemia and shoulder dystocia.…”

“…Reduction in neonatal weight after use of metformin has been reported by some studies. [2][3][4][5] But some studies have documented normal weight of neonates after metformin therapy.…”