Meth�moglobin�mie durch Prilocain nach Plexusan�sthesien

Abstract

In vitro high concentrations of ascorbic acid are able to reduce the resulting methemoglobin concentration 360 min after addition of 50 micrograms/ml o-toluidine. The application of 2,000 mg ascorbic acid i.v. before plexus anesthesia with prilocaine does not reduce the concentration of methemoglobin.

Successful Treatment with Ascorbic Acid in a Case of Methemoglobinemia Due to Glucose-6-Phosphate Dehydrogenase Deficiency

“…The most common causes of methemoglobinemia are exposure to oxidizing chemicals, consumption of nitrite- and nitrate-containing foods, and high doses of local anesthetics. 6 , 7 Methemoglobin accounts for about 1% of total hemoglobion under normal physiological conditions. When the MetHb level exceeds 10%, cyanosis occurs, while levels above 30% can cause tachycardia, weakness, nausea, vomiting, and respiratory distress.…”