Methadone-Induced Toxic Brain Damage

Corré, Jérôme; Pillot, J.; Hilbert, Gilles

doi:10.1155/2013/602981

Cited by 16 publications

(31 citation statements)

References 4 publications

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“…Involvement of the basal ganglia is also noticed in a few of these cases 6. A similar explanation may be given in cases of alcohol intoxication.…”

Section: Discussionsupporting

confidence: 58%

“…These were likely due to reduced brain perfusion 6. These lesions were bilaterally symmetrical, and the distribution of the affected areas was highly indicative of a toxic injury 6. Bilateral involvement of the basal ganglia and thalami has been reported in a few cases of ethylene glycol intoxication.…”

Section: Discussionmentioning

confidence: 99%

“…In humans, the opioid receptors are predominantly present in the cerebellum and the limbic systems, thus causing cerebellar-predominant toxicity in cases of opioid intoxication 6. Involvement of the basal ganglia is also noticed in a few of these cases 6.…”

Section: Discussionmentioning

confidence: 99%

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Magnetic resonance imaging features of brain and spinal cord injury in a fatal case of isopropanol intoxication

Mahajan¹,

Mathew²,

Jayaram³

et al. 2014

IMCRJ

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A 60-year-old man presented with headache, dizziness, and disorientation one day after consumption of isopropanol along with ethanol. Computed tomography (CT) of the brain performed immediately was unremarkable. The patient collapsed within the hospital 30 minutes after the CT scan was done, and remained comatose until death, showing no improvement with symptomatic treatment. Magnetic resonance imaging of the brain and spine done 6 days after admission revealed bilaterally symmetrical hyperintensities involving the cerebral and cerebellar cortex and white matter, basal ganglia, thalami, and brainstem on T2-weighted, fluid attenuated inversion recovery and diffusion weighted images; similar hyperintensities were seen involving the swollen and edematous cervical spinal cord and cerebellar tonsillar herniation compressing the proximal cervical cord. Petechial hemorrhages were also noted within the brainstem. These features are compatible with toxic injury to the brain and cervical spinal cord. To our knowledge, the magnetic resonance imaging features of brain and spinal cord injury and cerebellar tonsillar herniation, secondary to isopropanol intoxication have not been reported in the published literature before.

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“…Involvement of the basal ganglia is also noticed in a few of these cases 6. A similar explanation may be given in cases of alcohol intoxication.…”

Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic resonance imaging features of brain and spinal cord injury in a fatal case of isopropanol intoxication

Mahajan¹,

Mathew²,

Jayaram³

et al. 2014

IMCRJ

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show abstract

“…In addition, there is a cerebellar and basal ganglia involvement in methadone overdose as well [Corre et al, 2013]. Euphoria, slurred speech and ataxia were the most common initial symptoms of severe methadone poisoning [Caplehorn,1998].…”

Section: Discussionmentioning

confidence: 99%

Methadone use in a male with the FMRI premutation and FXTAS

Muzar

Lozano

Schneider

et al. 2015

American J of Med Genetics Pt A

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The fragile X-associated tremor ataxia syndrome (FXTAS) is caused by the premutation in FMR1 gene. Recent reports of environmental toxins appear to worsen the progression of FXTAS. Here we present a case of male adult with FXTAS and a long history of methadone use. The patient shows a faster progression in both symptoms of disease and MRI changes compared to what is typically seen in FXTAS. There has been no research regarding the role of narcotics in onset, progression, and severity of FXTAS symptoms. However, research has shown that narcotics can have a negative impact on several neurodegenerative diseases, and we hypothesize that in this particular case, methadone may have contributed to a faster progression of FXTAS as well as exacerbating white matter disease through RNA toxicity seen in premutation carriers.

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“…The results of Li et al (2016) suggested that methadone damages the integrity of the white matter of long‐time consumer of methadone in a dose‐dependent pattern . The radiological studies revealed that methadone in high concentration and long‐term consumption influences on the structure of the brain in the cerebellum, basal ganglia, and deep white matter of the cerebral hemispheres . For methadone, two signal paths have been suggested: one for binding to opioid receptors and another for acting as an antagonist in NMDR .…”

Section: Resultsmentioning

confidence: 99%

Suppressor capacity of iron nanoparticles biosynthesized using Salvia chloroleuca leaf aqueous extract on methadone‐induced cell death in PC12: Formulation a new drug from relationship between the nanobiotechnology and neurology sciences

Ahmeda

Zangeneh

Mansooridara

et al. 2020

Applied Organom Chemis

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Metallic nanoparticles have gained significant attention in the area of biomedical technology. Because of its high surface area, metallic nanoparticles are being widely used in various fields including the medical and engineering sciences. One of the valuable applications of metallic nanoparticles especially copper, zinc, and iron nanoparticles is increasing the physiological function of central nervous system. Besides, Iranian people are using the Salvia chloroleuca for neuroprotective properties. In the present research, iron nanoparticles were biosynthesized by S. chloroleuca leaf aqueous extract as reducing and stabilizing agents. Also, we revealed the protective effect of FeNPs in methadone‐treated PC12 cells. FeNPs were characterized and analyzed using common nanotechnology techniques including FT‐IR, UV–Vis. spectroscopy; EDS, TEM, and FE‐SEM. TEM and FE‐SEM images revealed a uniform spherical morphology for FeNPs. In the biological part of the current study, the both treatments of FeNPs significantly (p ≤ 0.01) reduced the cell cytotoxicity and cell death index as well as increased the cell viability and cell proliferation in methadone‐treated PC12 cells. In these treatments, mitochondrial membrane potential significantly (p ≤ 0.01) increased compared to methadone‐induced PC12 cells. DPPH free radical scavenging test was did to evaluate the antioxidant potentials of FeCl3, S. chloroleuca, and FeNPs. DPPH test indicated similar antioxidant activities for S. chloroleuca, FeNPs, and butylated hydroxytoluene. In current experiment, we concluded that iron nanoparticles biosynthesized by S. chloroleuca leaf aqueous extract suppressed methadone‐induced cell death in a dose‐dependent manner in PC12 cells.

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Methadone-Induced Toxic Brain Damage

Cited by 16 publications

References 4 publications

Magnetic resonance imaging features of brain and spinal cord injury in a fatal case of isopropanol intoxication

Magnetic resonance imaging features of brain and spinal cord injury in a fatal case of isopropanol intoxication

Methadone use in a male with the FMRI premutation and FXTAS

Suppressor capacity of iron nanoparticles biosynthesized using Salvia chloroleuca leaf aqueous extract on methadone‐induced cell death in PC12: Formulation a new drug from relationship between the nanobiotechnology and neurology sciences

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