Methadone Patients and Alcohol Abuse

Ottomanelli, Gennaro

doi:10.1016/s0740-5472(98)00030-0

Cited by 45 publications

(35 citation statements)

References 23 publications

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“…Inadequate opioid dosage during maintenance therapy may explain alcohol or other drug use in some patients. Ottomanelli [7] found that non-alcohol-abusing clients request higher doses of opioids. …”

Section: Clinical Correlates Of Aud In Opioid Dependencementioning

confidence: 99%

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Alcohol Use Disorders in Opioid Maintenance Therapy: Prevalence, Clinical Correlates and Treatment

Soyka¹

2014

Eur Addict Res

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Maintenance therapy with methadone or buprenorphine is an established and first-line treatment for opioid dependence. Clinical studies indicate that about a third of patients in opioid maintenance therapy show increased alcohol consumption and alcohol use disorders. Comorbid alcohol use disorders have been identified as a risk factor for clinical outcome and can cause poor physical and mental health, including liver disorders, noncompliance, social deterioration and increased mortality risk. The effects of opioid maintenance therapy on alcohol consumption are controversial and no clear pattern has emerged. Most studies have not found a change in alcohol use after initiation of maintenance therapy. Methadone and buprenorphine appear to carry little risk of liver toxicity, but further research on this topic is required. Recent data indicate that brief intervention strategies may help reduce alcohol intake, but the existing evidence is still limited. This review discusses further clinical implications of alcohol use disorders in opioid dependence.

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Section: Clinical Correlates Of Aud In Opioid Dependencementioning

confidence: 99%

“…Opioid dependence is frequently associated with polysubstance use and alcohol use disorders (AUD), and the latter cause multiple health and social problems [3,6,7,8]. This paper presents a comprehensive review of the existing literature on the prevalence and treatment of AUD in opioid dependence.…”

Section: Introductionmentioning

confidence: 99%

Alcohol Use Disorders in Opioid Maintenance Therapy: Prevalence, Clinical Correlates and Treatment

Soyka¹

2014

Eur Addict Res

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“…As for alcohol use problems in heroin-addicted patients, the prevalence rate of alcohol dependence is 19.1% in hospital subjects and 8.7% to 12.7 % in incarcerated subjects, respectively (Chen et al, 1999). Ottomanelli (1999) used the term alcoholism to encompass moderate to heavy drinking, harmful drinking, and alcohol dependence and reported a prevalence rate of 13% to 31% in patients undergoing methadone maintenance treatment (MMT). A recent study, using data from street illicit opioid and other drug users, reported a higher frequency of alcohol use among MMT users (Fischer et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Alcohol use problem among patients in methadone maintenance treatment in Taiwan

Chen

Chie

Hwu

et al. 2011

Journal of Substance Abuse Treatment

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“…An important drawback in the use of full opioid agonists such as methadone in the treatment of opioid dependence is the increase in ethanol intake often reported during maintenance treatment programs with these compounds (Backmund et al 2003;Bickel et al 1987;Ottomanelli 1999). This effect is attributed to the agonistic activity of these drugs at the μ-opioid receptors.…”

mentioning

confidence: 99%