Methamphetamine modulation of gene expression in the brain: Analysis using customized cDNA microarray system with the mouse homologues of KIAA genes

Yamamoto, Hiroyuki; Imai, Ken; Takamatsu, Yukio; Kamegaya, Etsuko; Kishida, Makiko; Hagino, Yoko; Hara, Yasuhiro; Shimada, Kiyo; Yamamoto, Toshiyuki; Sora, Ichiro; Koga, Hisashi; Ikeda, Kazutaka

doi:10.1016/j.molbrainres.2005.02.028

Cited by 24 publications

(12 citation statements)

References 23 publications

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“…Two hours after the injection, the striata from 10 mice per treatment group (a total of 160 mice were used) were quickly dissected on ice and immediately frozen at −80°C. The precise procedure for the cDNA array experiments is described elsewhere [38]. This developed a cDNA array system that utilized mouse KIAA-homologous cDNA (mKIAA) clones (http://www.kazusa.or.jp/rouge/; accessed July 7, 2013).…”

Section: Methodsmentioning

confidence: 99%

Involvement of the N-methyl-d-aspartate receptor GluN2D subunit in phencyclidine-induced motor impairment, gene expression, and increased Fos immunoreactivity

et al. 2013

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BackgroundNoncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists evoke a behavioral and neurobiological syndrome in experimental animals. We previously reported that phencyclidine (PCP), an NMDA receptor antagonist, increased locomotor activity in wildtype (WT) mice but not GluN2D subunit knockout mice. Thus, the aim of the present study was to determine whether the GluN2D subunit is involved in PCP-induced motor impairment.ResultsPCP or UBP141 (a GluN2D antagonist) induced potent motor impairment in WT mice but not GluN2D KO mice. By contrast, CIQ, a GluN2C/2D potentiator, induced severe motor impairment in GluN2D KO mice but not WT mice, suggesting that the GluN2D subunit plays an essential role in the effects of PCP and UBP141, and an appropriate balance between GluN2C and GluN2D subunits might be needed for appropriate motor performance. The level of the GluN2D subunit in the mature mouse brain is very low and restricted. GluN2D subunits exist in brainstem structures, the globus pallidus, thalamus, and subthalamic nucleus. We found that the expression of the c-fos gene increased the most among PCP-dependent differentially expressed genes between WT and GluN2D KO mice, and the number of Fos-positive cells increased after PCP administration in the basal ganglia motor circuit in WT mice but not GluN2D KO mice.ConclusionThese results suggest that the GluN2D subunit within the motor circuitry is a key subunit for PCP-induced motor impairment, which requires an intricate balance between GluN2C- and GluN2D-mediated excitatory outputs.

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Section: Methodsmentioning

confidence: 99%

Involvement of the N-methyl-d-aspartate receptor GluN2D subunit in phencyclidine-induced motor impairment, gene expression, and increased Fos immunoreactivity

et al. 2013

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“…Additionally, chronic daytime methamphetamine treatment shifts rhythmic Per1 and Per2 expression in the striatum from a nocturnal to a diurnal rhythm without affecting the rhythm in the SCN (153). Among genes altered in expression by methamphetamine treatment, the clock gene Per2 was most affected (154). Interestingly, mutation of the Per2 gene leads to a reduction of dopamine degradation (155), highlighting the mutual interaction of the circadian clock with dopamine levels in the striatum.…”

Section: Methamphetamine-sensitive Circadian Oscillator (Masco)mentioning

confidence: 98%

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

Dibner¹,

Schibler

Albrecht

2010

Annu. Rev. Physiol.

2,055

1,771

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Most physiology and behavior of mammalian organisms follow daily oscillations. These rhythmic processes are governed by environmental cues (e.g., fluctuations in light intensity and temperature), an internal circadian timing system, and the interaction between this timekeeping system and environmental signals. In mammals, the circadian timekeeping system has a complex architecture, composed of a central pacemaker in the brain's suprachiasmatic nuclei (SCN) and subsidiary clocks in nearly every body cell. The central clock is synchronized to geophysical time mainly via photic cues perceived by the retina and transmitted by electrical signals to SCN neurons. In turn, the SCN influences circadian physiology and behavior via neuronal and humoral cues and via the synchronization of local oscillators that are operative in the cells of most organs and tissues. Thus, some of the SCN output pathways serve as input pathways for peripheral tissues. Here we discuss knowledge acquired during the past few years on the complex structure and function of the mammalian circadian timing system.

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“…Additionally, chronic daytime methamphetamine treatment shifts rhythmic Per1 and Per2 expression in the striatum from a nocturnal to a diurnal rhythm, without affecting the rhythm in the SCN [220]. Among the genes coding for proteins involved in signal transduction, transcription, synaptic structure, and ion-channels, the gene most affected in its expression by methamphetamine treatment was the clock gene Per2 [255]. These findings highlight the mutual interaction of the circadian clock with psychostimulants.…”

Section: Drugs That Bind To Transporters Of Biogenic Aminesmentioning

confidence: 79%

The Circadian Clock

Albrecht¹

2010

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except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights.Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) v PrefaceWith the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most contributions in this volume focus on mammalian circadian clocks, the historical introduction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology.Circadian rhythms have been studied for centuries, but only recently, a molecular understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of mammals. Hence, a lot still needs to be discovered to get a full understanding of circadian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to discover novel concepts that ultimately need to be tested experimentally. In this development of new concepts lies the chance to understand living organisms better and to develop strategies to apply these new concepts for the benefit of society. A decade ago, the influence of changing day-night cycles (e.g. jet-lag and shift work) on health was intuitively possible but not taken very seriously due to lack of convincing scientific evidence. This has changed in the last years due to discoveries illustrating the involvement of clock components in the development of cancer, obesity and mood disorders.The main task of the circadian clock is to optimize an organism's performance and tune it with temporal changes in the environment. In that sense, the clock links the genetic setting of the organism with its environment. A better understanding of the circadian clock, therefore, will open avenues for treatment of diseases via environmental stimuli such as light. The importance...

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Methamphetamine modulation of gene expression in the brain: Analysis using customized cDNA microarray system with the mouse homologues of KIAA genes

Cited by 24 publications

References 23 publications

Involvement of the N-methyl-d-aspartate receptor GluN2D subunit in phencyclidine-induced motor impairment, gene expression, and increased Fos immunoreactivity

Involvement of the N-methyl-d-aspartate receptor GluN2D subunit in phencyclidine-induced motor impairment, gene expression, and increased Fos immunoreactivity

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

The Circadian Clock

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