Methamphetamine use behaviors and gender differences

Brecht, Mary‐Lynn; OʼBrien, Ann; Mayrhauser, Christina von; Anglin, M. Douglas

doi:10.1016/s0306-4603(03)00082-0

Cited by 385 publications

(358 citation statements)

References 44 publications

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“…While the main approach toward medications development has been to identify compounds that reduce methamphetamine's reinforcing effects associated with its abuse liability, the cognitive effects of potential compounds and their interaction with methamphetamine need to be fully characterized. This is because the need to increase cognitive performance is often cited as a reason for initiating or maintaining methamphetamine use (Brecht et al, 2004;von Mayrhauser et al, 2002). Hence, it might be difficult to maintain clinical compliance, even with an efficacious compound, should it have profound effects on cognitive performance either alone or in combination with methamphetamine.…”

Section: Introductionmentioning

confidence: 99%

Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individuals

Johnson

Roache

Ait-Daoud

et al. 2007

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Methamphetamine-dependent individuals often cite the need to maintain enhanced cognitive performance and attention as a reason for continuing or relapsing to drug-taking. Further, methamphetamine addicts might not comply with taking a potentially therapeutic medication if it had a profound effect on these cognitive processes. Topiramate, a sulfamate-substituted fructopyranose derivative, has been suggested as a putative therapeutic medication for treating methamphetamine dependence. Examination of topiramate's effects on cognitive performance and attention is a clinically and scientifically important component of understanding its potential therapeutic profile. In 10 male and female individuals who met DSM-IV criteria for methamphetamine dependence, we examined the effects of low (50 mg b.i.d.)-and high (100 mg b.i.d.)-dose topiramate -in both the presence and absence of low (15 mg)-and high (30 mg)-dose intravenous methamphetamine -on cognitive performance, attention, and concentration on the rapid visual information processing task and the digit symbol substitution test. Intravenous methamphetamine enhanced cognitive performance, attention, and concentration among recently withdrawn methamphetamine addicts -an effect that hitherto had not been well characterized. Topiramate's cognitive effects were mixed and rather paradoxical, with a tendency to improve attention and concentration both alone and in the presence of methamphetamine while worsening psychomotor retardation. No deleterious interaction occurred between topiramate and methamphetamine on any of these cognitive processes. While clinical studies with topiramate should Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access

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Section: Introductionmentioning

confidence: 99%

Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individuals

Johnson

Roache

Ait-Daoud

et al. 2007

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Brecht et al, 2004;Westermeyer and Boedicker, 2000). For example, in one sample of 350 methamphetamine abusers (56% male), women advanced to regular use, defined as using 3 or more days per week, more quickly than men (1.6 years and 2.6 years, respectively) and entered treatment after fewer years of drug use (8.8 years and 9.7 years, respectively) (Brecht et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Similar discriminative-stimulus effects of d-amphetamine in women and men

Vansickel

Lile

Stoops

et al. 2007

Pharmacology Biochemistry and Behavior

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The results of controlled non-human animal and human laboratory studies are mixed regarding whether women and men respond differently to stimulant drugs. In order to assess potential gender differences in the effects of d-amphetamine, we conducted a retrospective-analysis of six studies conducted in our laboratory that used identical procedures and measures. Thirteen women and fourteen men learned to discriminate 15 mg oral d-amphetamine. After acquiring the discrimination (i.e., =80% correct responding on 4 consecutive sessions), the effects of a range of doses of damphetamine (0, 2.5, 5, 10, and 15 mg) alone and in combination with other drugs, were assessed. Only data from sessions in which d-amphetamine was administered alone were included in this analysis. d-Amphetamine functioned as a discriminative-stimulus and dose-dependently increased drug-appropriate responding. Women and men did not differ in their ability to discriminate damphetamine. Women and men differed on participant-ratings of high (women < men), nausea (women > men) and sluggish (women < men), women also experienced greater increases in diastolic pressure than men. Because the results of this study may have been confounded by the training procedures, future research should use other behavioral arrangements (e.g. drug self-administration) to determine if women and men respond differently to the effects of d-amphetamine.

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“…In addition to the already mentioned subpopulations, it is important to note the specific effect of gender on the presentation of SUDs and on SUD treatment in particular, due to its substantial effect on SUD histories, treatment processes, and treatment outcomes [39][40][41][42][43][44][45][46][47][48][49].…”

Section: Chronic Unemploymentmentioning

confidence: 99%

“…Women with SUDs often enter drug treatment with more severe problems than men related to criminality, SUD histories, mental health disorders, employment, drug use among partners or family members, and childcare responsibilities [39][40][41][42][43][44][45][46][47].…”

Section: Moderating Effects Of Gendermentioning

confidence: 99%

Cost Variation among Subpopulations of Diverted Drug Offenders under California’s Proposition 36

Anglin¹

2014

J Alcohol Drug Depend

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Objectives: To explore differences in government costs among several subpopulations of offenders who were eligible to participate in California's Proposition 36, enacted as the Substance Abuse and Crime Prevention Act of 2000 (SACPA). Methods:The study compared a time-lagged cohort of offenders meeting SACPA eligibility criteria before SACPA was enacted (N=42,706) to the first-year SACPA cohort (N=37,991). Difference-in-differences (DID), multilevel, multivariate, random-effects regression models that included membership in the subpopulation categories (criminal, mental health, employment) and interaction terms were estimated separately for men and women to determine the effect of SACPA on total costs and across eight cost domains (prison, jail, probation, parole, health, arrests, convictions, and treatment).Results: A substantial proportion of SACPA participants had significant chronic problems. SACPA-eligible male offenders with extensive criminal histories yielded greater DID savings than low-history offenders, an effect augmented by SACPA participation. Among female offenders with extensive criminal histories, overall savings were negated by increased arrest/conviction costs. A documented history of mental illness resulted in increased costs for men and women.Conclusions and implications for practice: SACPA participation was cost-effective among more severe cases, especially for male offenders with extensive criminal histories; however, the program did not attenuate increased costs for offenders with severe mental illness. Services for the special needs of such offender populations need further development and implementation.

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Methamphetamine use behaviors and gender differences

Cited by 385 publications

References 44 publications

Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individuals

Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individuals

Similar discriminative-stimulus effects of d-amphetamine in women and men

Cost Variation among Subpopulations of Diverted Drug Offenders under California’s Proposition 36

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